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Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer's disease
(2009-09-04)Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder of the central nervous system. Diagnosis and monitoring of sporadic AD has long depended on clinical examination of individuals with end-stage ... -
Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury
(2020-01-07)Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a ... -
Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies
(2019-09-10)Abstract Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and ... -
Taurine and dopamine-related effects of ethanol. An experimental study in rodents
(2019-11-18)The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought ... -
The adjustable shunt valve in the treatment of adult hydrocephalus - Effect on clinical symptoms, intracranial pressure and complications
(2014-05-26)Background: Hydrocephalus causes impaired gait, balance, cognition and continence, all of which can be reversed by shunt treatment. Adjustable valves are commonly used in the shunt treatment of hydrocephalus but randomized ... -
The challenge of communication during home mechanical ventilation
(2011)The overall aim of this thesis was to explore and describe experience of communication during home mechanical ventilation (HMV) in adults, thereby contributing to increased knowledge and awareness of issues related to ... -
The dynamic nature of participation - Experiences, strategies and conditions for occupations in daily life amongst persons with late effects of polio
(2016-02-26)Aim: The overall aim of this thesis was to explore the conditions for daily occupations, and how these are reflected in the daily lives of people with the late effects of polio. Four studies (studies I–IV) are included in ... -
The gut-brain axis and alcohol-mediated behaviours: the amylin story
(2019-10-29)Alcohol use disorder (AUD) is a complex neuropsychiatric disorder with high rates of mortality and morbidity. The currently available pharmacotherapies show varied efficacy, leading to the investigation of new neurochemical ... -
The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements
(2012-08-28)Although stroke is a common cause of death and disability in adults, there are few studies on stroke compared to other common diseases. A stroke could be either ischemic or hemorrhagic, but even within these two groups, ... -
The impact of glucagon-like peptide-1 on the brain-reward system and beyond
(2015-09-09)Glucagon-like peptide-1 (GLP-1), produced in the intestine and the brain, regulates food intake and glucose metabolism. A GLP-1 based treatment is already approved for clinical use in type 2 diabetes patients, and recently ... -
The medical perspective in prescribing: measurements and educational strategies
(2021-08-18)Background and aims: Drug treatment is a keystone in modern healthcare and for safe prescribing of drugs, an overall medical perspective has to be applied, taking patient characteristics into account. For each medication, ... -
The Modified Version of the Postural Assessment Scale for Stroke Patients. Measurement properties and a longitudinal follow-up.
(2012-11-20)The Modified Version of the Postural Assessment Scale for Stroke Patients (SwePASS) Measurement properties and a longitudinal follow-up Carina U Persson Department of Rehabilitation Medicine, Institute of Neuroscience ... -
The neuromodulatory effect, safety and effectiveness of vagus nerve stimulation
(2017-03-22)Background Vagus nerve stimulation (VNS) is an adjunctive palliative neuromodulatory treatment for drug resistant epilepsy (DRE) and chronic depression. It has also been proposed as a treatment for many other conditions ... -
The neuropsychology of idiopathic normal pressure hydrocephalus
(2011-05-09)Idiopathic normal pressure hydrocephalus (iNPH) is characterised by an active distension of the cerebral ventricles due to inadequate absorption of cerebrospinal fluid (CSF) into the systemic circulation. The intracranial ... -
The neurovascular niche after irradiation to the developing brain
(2013-11-11)Radiotherapy is commonly used in the treatment of pediatric brain tumors but is unfortunately associated with debilitating negative effects, such as impaired memory and learning. Historically, vascular damage following ... -
The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models
(2020-02-27)Alzheimer’s disease (AD) is characterized by cognitive impairment due to the loss of structure and/or function of neurons, and amyloid plaques composed of aggregated-amyloid beta (Aβ) peptides, primarily species ending at ... -
The postsynaptic protein neurogranin: a new item in the Alzheimer’s disease biomarker toolbox
(2019-03-13)Alzheimer’s disease (AD) is the most common form of dementia affecting more than 50 million people worldwide today and is characterised by progressive cognitive decline. One of the earliest events in AD, which is also ... -
The role of astrocytes in stroke, brain plasticity and neurogenesis
(2013-05-10)Astrocytes, one of the most abundant and heterogeneous cell types in the central nervous system, fulfill many important roles in the healthy and injured brain. This thesis investigates the role of astrocytes in the neurogenic ... -
The role of estrogen and superoxide dismutase in cataractogenesis
(2014-11-03)Cataract is an opacification of the eye lens, constituting the major cause of blindness globally. Oxidative stress is a key factor in the formation of cataract and female gender is a known risk factor for age-related ... -
The role of glycoproteins in glomerular pathophysiology
(2021-09-01)Chronic kidney disease (CKD) is increasing worldwide and has a prevalence of around 10%. With time patients are at risk of losing their renal function and will need dialysis or transplantation for survival. There are no ...