Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 320-339 of 479
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Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation
(2020-06-12)ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and ... -
Parkinson's disease and motor function - a validation of the PLM method
(2013-09-27)Aim: To validate the Posturo-Locomotor-Manual (PLM) test, an objective movement measurement system designed to measure movement disability in patients with Parkinsonism. Method: The reliability of the PLM test was determined ... -
Participation after stroke in a short- and long-term perspective
(2019-10-15)The main scope of this thesis was to study and describe perceived participation among persons with stroke. In doing so, different timepoints were chosen to make a more complete picture of participation after stroke. The ... -
Pathophysiological regulation of white adipocyte exocytosis of different adiponectin molecular forms
(2019-03-06)In this thesis we have identified mechanisms involved in the exocytosis of different adiponectin molecular forms in health and in metabolic disease. We have also studied similarities and differences in depot-specific ... -
A pathway for pleasant touch: linking peripheral receptors to central processing and hedonic experience
(2009-11-10)This thesis investigates the mechanisms underpinning pleasant touch, describes a pathway from peripheral nerve endings in the skin to the insular cortex, and relates these findings to the subjective hedonic experience of ... -
Patience you must have, my young athlete - Rehabilitation specific outcomes after anterior cruciate ligament reconstruction
(2019-05-07)An anterior cruciate ligament (ACL) injury is one of the most common knee-related injuries, usually occurring in younger individuals during sports participation. Moreover, almost 1 in 4 of younger athletes sustain a ... -
Perinatal Staphylococcus epidermidis infection and the immature brain: a neuroinflammatory link
(2022-05-27)Preterm birth and its associated complications are among the most serious global health issues that modern society faces. Due to the prolonged medical care and immature immune system, preterm infants have a higher ... -
Person-centred care and communication disorders: Exploration and facilitation of conversational interaction involving people with acquired neurogenic communication disorders and health care providers
(2017-05-08)Functional communication is a prerequisite for person-centred care. However, the presence of acquired neurogenic communication disorders makes the delivery of person-centred care challenging for health care providers and ... -
Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT
(2023-11-15)N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the ... -
Pharmacokinetics of artemisinin derivatives in rats, healthy volunteers and patients
(2015-09-04)Malaria is still a major health problem, killing approximately 1,600 people each day. The most vulnerable patient groups are children under the age of five and pregnant women. Artemisinin-based combination therapy is ... -
Physical activity among patients undergoing bariatric surgery
(2013-04-30)The World Health Organization (WHO) recommend that adults should perform ≥150 minutes of moderate intensity physical activity or ≥75 minutes of vigorous intensity physical activity or an equivalent combination of ... -
Physical activity and stroke - Associations and patient experiences
(2023-11-15)Background: Insufficient physical activity is a global problem and a risk factor for stroke. Furthermore, physical activity is often reduced after stroke, and many patients are physically inactive in stroke units. Aim: ... -
Physical activity on prescription in primary care. Impact on physical activity level, metabolic health and health-related quality of life, and its cost-effectiveness - a short- and long-term perspective
(2020-10-08)Non-communicable diseases (NCDs) are the leading cause of death globally and one of the major health challenges of the 21st century. In Sweden, NCDs are estimated to account for 90 % of all deaths. Strong evidence indicates ... -
Physical fitness and exercise in adults with congenital heart disease
(2020-04-14)Background: The population of patients with adult congenital heart disease (ACHD) is growing, and the estimated life expectancy has increased. Therefore, factors related to lifestyle, such as physical activity (PA), exercise, ... -
Physical performance and physical activity in the later stage post-stroke
(2012-11-21)Aims: The overall purpose of this thesis was to increase knowledge about physical performance and activity in the later stage post-stroke by measuring walking performance in different environments coupled to muscle strength, ... -
Physiological role of amyloid precursor protein during neural development
(2017-05-22)Amyloid precursor protein (APP) is a type-one membrane-spanning protein with a large extracellular N-terminal domain and a small intracellular C-terminal domain. APP first gained interest due to its involvement in the ... -
Physiological roles of amyloid precursor protein in vivo - zebrafish as a model
(2021-10-26)Amyloid-beta precursor protein (APP) is an evolutionarily conserved transmembrane protein expressed in many different tissues. APP belongs to a gene family consisting of two other APP-like proteins (APLP1 and APLP2). APP ... -
Physiology and Pathophysiology of Hormone Secretion from lslets of Langerhans
(2023-10-30)Diabetes is a metabolic disorder stemming from the improper regulation of blood glucose levels by hormones secreted by pancreatic islets of Langerhans. Paper I describes the mechanism by which glucose can regulate glucagon ... -
Physiotherapist as primary assessor of knee osteoarthritis in primary care - Evaluation of patients’ self-assessment, preferences, quality of life, and health economy
(2024-03-27)Aim: The purposes with this thesis was to evaluate the feasibility of 30-second chair stand test as a self-test, and to investigate the effects of direct access to physiotherapist on costs and health in people with knee ... -
Physiotherapist-led orthopaedic triage - assessment and management of musculoskeletal disorders in primary care
(2016-11-23)The overall aim of this thesis was to evaluate physiotherapist-led orthopaedic triage of patients with musculoskeletal disorders in primary care in comparison to standard practice. The thesis comprises two studies (A and ...