Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 245-264 of 477
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Machine learning and big data for personalized epilepsy treatment
(2023-05-23)Finding an effective anti-seizure medication (ASM) with minimal side effects is a challenge. Patient characteristics are used to guide treatment selection, but about half of the patients with epilepsy do not achieve seizure ... -
Machine learning for identification of brain activity patterns with applications in gentle touch processing
(2009-10-23)Since the first mention of artificial intelligence in the 1950s, the field of machine learning has provided increasingly appealing tools for recognition of otherwise unintelligible pattern representations in complex data ... -
Mass spectrometric quantification of amyloid-beta in cerebrospinal fluid and plasma
(2015-10-07)Alzheimer’s disease (AD) is the most common neurodegenerative disease among the elderly and accounts for 60-80% of all cases of dementia. Currently, the diagnosis of AD is based on cognitive tests and mental state exams, ... -
Mass spectrometry based proteomic strategies applied in the study of central nervous system derived cells
(2007-03-26)This thesis focuses on evaluation, improvement and development of mass spectrometry based proteomic strategies for identification and quantitation of proteins. Development of such strategies is important to achieve a better ... -
Measuring outcomes following brain tumor surgery: a registry based approach
(2021-05-27)Meningiomas and vestibular schwannomas (VS) are generally slow-growing and benign brain tumors, with low rates of tumor-related mortality. Surgery is rarely the only viable treatment option. In cases where there is no clear ... -
Measuring the tactile sense: Cortical mechanisms and clinical applications of tactile direction discrimination
(2011-03-18)Most of the studies aiming to investigate the human tactile sense are done on the glabrous skin. Still, there is a need for a quantitative method for evaluating nervous function of the hairy skin. Tactile direction ... -
Mechanism of Action of the Antiarrhythmic Agent AZD7009
(2007-01-26)Atrial fibrillation (AF) is the most common tachyarrhythmia in the adult population and is a major cause of morbidity and mortality. AF can be terminated and sinus rhythm restored by prolonging the action potential duration ... -
Mentally disordered offenders: a longitudinal study of forensic psychiatric assessments and criminal recidivism
(2013-08-27)Background: During history, mentally disordered offenders have been in focus regarding responsibility for their crimes and imposition of punishment. The boundary stone of legal consequences for mentally ill offenders has ... -
Metabolic and immunological interactions between adipose tissue and breast cancer - implications of obesity in tumor progression
(2019-10-16)Triple-negative breast cancers have fewer treatment options than other breast cancers. The overall goal of this research is to identify new pharmaceutical targets for triple-negative breast cancer through studies of the ... -
Metabolic and ovarian consequences of perinatal sex steroid programming
(2008-11-24)Endocrine and metabolic disturbances in adulthood may stem from insults such as nutritional and hormonal alterations that occur at critical periods in pre- or postnatal life – a process known as programming. This means ... -
Microglial Glutamate Transporters - Regulation of Expression and Possible Physiological Functions
(2007-05-15)Microglia are considered as the immunocompetent cells of the central nervous system (CNS). Being the first line of defence, they have prominent roles in monitoring the homeostasis and the extracellular milieu and can rapidly ... -
Mild Cognitive Impairment - concepts, cut-offs, and clinical relevance
(2019-04-25)Mild cognitive impairment (MCI) is a diagnosis frequently used in dementia research and in memory clinics. MCI is meant to identify patients without dementia, but with cognitive decline beyond what is considered normal, ... -
Mild intellectual disability: Diagnostic and outcome aspects
(2013-11-29)The aim of the thesis was to describe mild intellectual disability (ID) from various neurodevelopmental and neuropsychiatric perspectives in children and young adults. Paper I The objective of the first paper was to ... -
Mild stroke - consequences in everyday life, coping and life satisfaction.
(2007-04-25)Abstract Aim: The aim of this thesis was to explore the life situation one year after an apparently mild stroke, and to compare life satisfaction between patients and their spouses. Method: Seventy-five patients with ... -
Modelling of tolerance and rebound in normal and diseased rats
(2011-05-27)The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, ... -
Molecular and physiological regulation of adiponectin exocytosis in white adipocytes
(2015-11-23)In this thesis we have investigated the mechanisms of white adipocyte regulated exocytosis in health and disease, with a special focus on adiponectin. We have applied a combination of electrophysiological membrane capacitance ... -
Molecular perspectives on glomerular cell physiology in chronic kidney disease
(2019-05-24)Glomerulonephritis is one of the most common causes of chronic kidney disease (CKD) in the world. Recent establishment of guidelines for classification of CKD in five stages has led to increased awareness of the risks of ... -
Moved by movement: A person-centered approach to physical therapy in the treatment of major depression
(2015-05-12)Major depression (MD) is a common and debilitating condition. To expand knowledge on adjunctive treatment perspectives, this thesis explores a physical therapy approach in the treatment of MD. Specifically, in five studies, ... -
A Multimodal Approach toward the Biological Categorization of Autism - Development of Theoretical Models, Classification Methods, and Biomarkers
(2022-11-18)Autism Spectrum Disorder (ASD) is an umbrella term for a group of neurodevelopmental disorders (NDD) which are behaviorally defined by the presence of difficulties with social communication, and behavioral rigidity and ... -
Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2019-08-30)Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired ...