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Candidate biomarkers for synaptic pathology: neurogranin, neuroligins and neurexins in neurodegenerative disorders
(2021-05-14)Synapses are small units through which neurons communicate in the brain. They represent the site of memory formation and cognitive abilities and are thus primarily affected by neurodegenerative diseases such as Alzheimer’s ... -
Capturing the experience of health among persons aging in a migration context - Health promotion interventions as means to enable health and occupations in daily life
(2018-09-28)Aim: The overall aim of this thesis was to increase our understanding of health in everyday life among older persons aging in migration, and to evaluate the outcome of a health promotion intervention on sense of coherence, ... -
Cardiometabolic risk indicators in bipolar disorders
(2023-05-15)In addition to disabling mood episodes, bipolar disorders (BDs) predispose individuals to high cardiovascular disease (CVD) risk. This thesis explores the association between BDs and the metabolic risk indicators body mass ... -
Central actions of glucagon-like peptide-1 on food intake and reward: Novel neurological targets and sex divergent effects
(2019-12-06)Obesity is one of the biggest health risks of our society; however, treatment options are sparse and often result in suboptimal weight-loss. The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist liraglutide was ... -
Central and Systemic Inflammation in Developmental Brain Injury
(2014-11-21)Brain injury occurring during the perinatal period is an important cause of mortality and morbidity with potentially life long consequences. Both preterm and asphyxiated full term infants are at high risk of developing ... -
Central modulation of affective touch, pain and emotions in humans
(2014-05-15)Hedonic feelings – pleasure and displeasure – strongly motivate human behavior. When well-functioning, hedonic feelings guide adaptive decision-making that promotes survival and well-being. Specialized afferent systems ... -
Cerebral Venous Thrombosis - Complications and Outcomes
(2022-05-17)Cerebral venous thrombosis (CVT) is a relatively rare cause of stroke, which predominantly affects working-aged adults and particularly women. The clinical course is highly miscellaneous. Data from large cohorts are scarce ... -
Cerebral white matter changes in patients with cognitive impairment - clinical and pathophysiological aspects
(2012-04-04)Cerebral white matter changes (WMC), detected with computed tomography (CT) or magnetic resonance imaging (MRI), represent a common condition in elderly people. However, the prognostic, symptomatological and biochemical ... -
Cerebrospinal fluid biomarkers and cognition in older adults
(2021-04-21)Alzheimer’s disease (AD) is the most common type of dementia. The cause of the disease is unknown, but a substantial amount of evidence suggest that the disease is started by an imbalance in the production and clearance ... -
Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
(2011-05-27)Patients suffering from mild cognitive impairment (MCI) run a higher risk of developing dementia, with Alzheimer’s disease (AD) being the most common form. Vascular dementia (VaD) is proposed to be the second most common ... -
Cerebrospinal Fluid Biomarkers in Neurodegenerative Movement Disorders: Parkinsonian Disorders and Huntington's Disease
(2013-04-29)Background: Parkinson’s disease (PD) and atypical parkinsonian disorders (APD) [multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD)] are a large group of idiopathic ... -
Cerebrospinal fluid peptidomics: discovery of endogenous peptides as biomarkers of Alzheimer's disease
(2018-10-02)Neurodegenerative diseases (NDs), the most prominent example of which is Alzheimer’s disease (AD), has turned out to be among the greatest challenges for modern medicine. Common characteristics of NDs involve the aggregation ... -
Cerebrospinal fluid studies of bipolar disorder
(2022-04-14)The pathophysiology of bipolar disorder remains to be elucidated. One approach to studying brain processes is analysis of cerebrospinal fluid (CSF). This thesis comprises five studies based on the Sankt Göran Bipolar Project ... -
Changes in writing processes caused by post-stroke aphasia or low-grade glioma
(2019-12-11)Background: Writing is a cognitively and linguistically complex task, therefore sensitive to impairment caused by the presence and surgical removal of low-grade glioma or presence of post-stroke aphasia. Purposes: The ... -
Characterisation and semi-mechanistic modelling of eflornithine pharmacokinetics and evalutation of prodrugs in oral treatment against late-stage human African trypanosomiasis
(2013-05-22)The present thesis explores the hypothesis that treatment of human African trypanosomiasis can be improved by characterising the enantioselective pharmacokinetics of eflornithine, and investigating the oral eflornithine ... -
Characterization of immune cell profiles in meninges and brain parenchyma following injury in the developing mouse brain
(2021-02-04)Preterm newborns are particularly susceptible to complications such as hypoxia-ischemia (HI), which can result in brain injury and subsequent cognitive and/or motor function disabilities, including cerebral palsy. Immune ... -
Characterization of secretory mechanisms in lacrimal and salivary glands
(2021-03-25)Dry mouth and dry eyes are multifactorial morbidities that can lead to a severely reduced quality of life. Approximately 20% of the population suffers from ocular or oral dryness. In the pursuit of pharmacological treatments ... -
Chemical and stimulus-induced NMDA-dependent plasticity and the possible involved mechanisms
(2006-11-08)Long-term potentiation (LTP) and long-term depression (LTD) are considered as the most important forms of synaptic plasticity involved in learning and memory. The traditional way to induce LTP and LTD is by electric ... -
Child Sexual Abuse: Crimes, Victims, Offender Characteristics, and Recidivism
(2012-09-21)Background: Epidemiological research on child sexual abuse relies on health care surveys, anonymized population surveys, and criminal statistics, each with its methodological limitations. This study aims at compensating ... -
Children who screen positive for language delay but not autism: from 2.5 to 6 years of age
(2023-12-05)Background: Language disorders (LDs) are prevalent, affecting approximately 10% of children. Among them, 7.5% have developmental language disorder (DLD), while 2.5% have LD associated with a known medical condition. In ...