Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 362-381 of 477
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Prodromal Cognitive Signs of Dementia
(2009-04-24)The increase in proportion of elderly worldwide, coupled with the fact that increasing age is a primary risk factor for dementia, have fuelled the efforts to unveil the warning signs of dementia. Although important ... -
Progesterone receptor-mediated effects on apoptosis in periovulatory granulosa cells
(2006-11-28)The most common fate of developing ovarian follicles is demise due to a process known as atresia. Regulation of atresia is dependent on the developmental stage of the follicles, resulting in a continuous reduction of the ... -
Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders
(2008-04-04)ABSTRACT There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact ... -
Psychiatric symptoms and disorders in old age: prevalence, course and diagnostic thresholds
(2015-09-04)The aim of this thesis was to study the epidemiology of some psychiatric disorders, as well as their corresponding subthreshold symptoms, in order to explore the border between psychopathology and normality in the general ... -
Psychological stress in relation to dementia and brain structural changes
(2012-09-03)Psychological stress has been recognized as an increasing public health problem with serious consequences in both physical and mental health. Women reported a higher prevalence of psychological stress, especially in midlife. ... -
Purinergic effects in the rat urinary bladder. Functional studies of cyclophosphamide treatment on afferent and efferent mechanisms
(2013-02-27)Pathological conditions in the lower urinary tract are common and have a great impact on the quality of life for the patients suffering from such disorders. In this thesis cyclophosphamide (CYP)-induced cystitis, a ... -
Quality assessment of ADL instrument and evaluation of ADL ability in individuals with cervical spinal cord injury after reconstructive hand surgery
(2017-04-28)Abstract Background: A spinal cord injury (SCI) leads to dramatic changes in an individual’s life and the rehabilitation after the injury is a lifelong process. For persons with cervical spinal cord injury (SCI), the ... -
Quality of drug treatment in older people from a medical primary care perspective and according to indicators
(2023-05-09)Background: Drug treatment in older people is particularly complex; the burden of disease increases by age, and patients in this age group are more sensitive to drug effects. As a knowledge resource for clinicians as well ... -
Quantitative Clinical Pharmacological Studies on Efavirenz and Atazanavir in the Treatment of HIV-1 Infection
(2012-11-22)There are 34 million people infected with the HIV-1 virus in the world today. Due to increased access to antiretroviral therapy, AIDS related death has dropped by 30% since 2005. Optimizing the pharmacotherapy of the HIV-1 ... -
Quantitative neuroproteomics for biomarker discovery in Alzheimer's disease
(2014-01-17)Alzheimer’s disease (AD) is the most common form of dementia characterized by amyloid plaques and neurofibrillary tangles in the brain. Novel biomarkers for AD are needed that reflect disease progression and could identify ... -
Radiological and Clinical Changes in Idiopathic Normal Pressure Hydrocephalus: MRI, Vascular factors and Clinical Symptoms as Markers of Pathophysiology and Prognosis
(2020-01-15)Idiopathic normal pressure hydrocephalus (iNPH) is a treatable, neurological disorder affecting the elderly population causing gait, balance, cognitive and micturition impairments. Treatment results in a clinical improvement ... -
Re-evaluation of the hypothesis that LTP has two temporal phases and that the late phase is protein synthesis-dependent
(2015-02-19)Long-term potentiation (LTP) is an activity-dependent increase in synaptic efficacy that is most studied in the hippocampus and that is considered a cellular substrate for learning and memory. Accepting the belief that the ... -
Reactive gliosis in the injured brain: The effect of cell communication and Nrf2-mediated cellular defence
(2011-02-18)Stroke and other brain injuries trigger an extensive glial cell response referred to as reactive gliosis. Reactive gliosis is characterized by hypertrophic and proliferating astrocytes, proliferating microglia and NG2-positive ... -
Recidivism and Static-99R risk assessments in a Swedish cohort of mentally disordered sexual offenders
(2021-05-07)Mentally disordered sexual offenders (MDSOs) constitute a heterogeneous offender subgroup presenting a wide range of clinical comorbidity. The recidivism rates for such a disparate subgroup vary substantially, which ... -
Regional differences in the response of neural stem cells and their microenvironment to ionizing radiation
(2009-05-14)Radiation therapy is one of the most effective tools for treating malignant tumors; however, cranial irradiation often results in intellectual impairment and cognitive deficits, such as impaired learning and memory. Ionizing ... -
Registry-based studies of return to work after stroke - part of the work after stroke study (WASS)
(2021-02-15)Objectives. Stroke is one of the most common diseases and a main cause of disability both globally and in Sweden. Even though the risk increases with older age, stroke in the younger population is increasing and a substantial ... -
Regulation of amyloid beta generation and its involvement in synaptic function: studies in human iPSC-derived cortical neurons
(2024-02-21)Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and exerts a profound societal and economic impact. Clinically characterized by a gradual loss of memory, cognitive and ... -
Regulation of postnatal neurogenesis and brain angiogenesis by thyroid hormone
(2009-12-07)Thyroid hormone (TH), which is secreted by the thyroid gland, exerts significant effects on the central nervous system (CNS), especially during development, so that delayed treatment of perinatal hypothyroidism results ... -
The relationship between cognition and ESSENCE in childhood
(2023-08-29)Aims: To examine the relationship between cognition and ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) features in children, ages 7-8 years. To investigate the importance of ... -
The reserve concept in patients with Mild Cognitive Impairment - new approaches
(2010-03-26)The concept of reserve stems from the observation that premorbid factors, e.g. education, result in variation in the response to any kind of brain pathology. As subjects with higher reserve tolerate more neuropathology, ...