Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 345-364 of 477
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Plasticity of the developing glutamate synapse in the hippocampus
(2007-08-21)Synapses are highly plastic, i.e. they have the ability to change their signaling strength both in the short- and long-term (e.g. long-term potentiation - LTP) in response to specific patterns of activity. In the developing ... -
Polycystic ovary syndrome - Effect of acupuncture on insulin resistance and neuroendocrine function
(2013-02-08)Although polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women in reproductive age the etiology and pathophysiology are poorly understood. PCOS is characterized by hyperandrogenism, polycystic ... -
Polycystic ovary syndrome - Studies of metabolic and ovarian disturbances and effects of physical exercise and electro-acupuncture
(2010-01-15)Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in premenopausal women. The syndrome is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian (PCO) morphology. Metabolic ... -
Polycystic ovary syndrome in women with severe obesity - effects of a 12-month weight loss intervention
(2024-03-19)Background: Polycystic ovary syndrome (PCOS) affects one out of eight women and is associated with reproductive, metabolic, and psychiatric features. There is a strong association with obesity but studies on PCOS in women ... -
Polycystic Ovary Syndrome. Androgen excess and insulin resistance in women: Identification of molecular targets to improve glucose homeostasis
(2018-01-08)Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in women. Women with PCOS demonstrate metabolic morbidities such as obesity, insulin resistance with compensatory hyperinsulinemia and ... -
Population Pharmacokinetic-Pharmacodynamic Modelling of Antimalarial Treatment
(2014-11-28)Malaria is one of the most important tropical diseases, with hundreds of millions of cases every year. The current recommended treatment is an artemisinin based combination therapy (ACT), which has shown good efficacy. ... -
Population-based studies of brain tumor surgery: surgical outcome and prognostic factors
(2020-08-27)Neurosurgery is the cornerstone in the treatment of a majority of brain tumors. Surgery can sometimes cure or delay tumor progression. However, surgery is associated with risks, and adequate information about the anticipated ... -
Postural balance, anxiety and motor function after stroke, at a very early supported discharge with continued rehabilitation
(2020-10-23)The overall aim of this thesis was to investigate postural balance, anxiety and motor function the first year after stroke and whether postural balance, anxiety and motor function was different at the intervention of Very ... -
Pre-, peri- and postnatal influences on ophthalmologic outcome - a study on children born after intracytoplasmic sperm injection (ICSI) and children born preterm
(2009-05-13)The aims of the present study were to investigate the effects of prenatal factors in children born after intracytoplasmic sperm injection (ICSI) and peri- and postnatal factors in children born preterm on visual function ... -
Pre/Peri/Earl-Life Exposures and Early Child Neurodevelopment: Results from the Japan Environment and Children's Study (JECS)
(2023-08-18)Background: Combinations of genetic and environmental factors contribute to aetiologies of neuropsychiatric problems and neurodevelopmental disorders (NDDs) in intricate manners. Among the environmental factors, exposures ... -
Precision in neuropsychology. Four challenges when using simplified assumptions
(2019-05-16)Cognition comprises all thought processes, from perception to memory. Neuropsychological tests are the gold standard (= best way) to measure cognition. However, clinical assessment may at times have to rely on simplified ... -
Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
(2011-02-02)Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter ... -
Prediagnostic and comorbidity factors in preschool children with autism
(2015-08-31)The aim of the thesis was to investigate Autism Spectrum Disorder (ASD) diagnosed in the early years from different angles; screening, load of coexisting disorders, outcome at routine developmental surveillance, and to ... -
Predictors of long-term outcome after severe traumatic brain injury
(2013-12-20)Aim: A complex interaction between several factors may influence and explain the variance in outcome after traumatic brain injury (TBI). The overall aim of this thesis was to explore, in individuals with severe TBI, the ... -
Predictors of Outcome after Anterior Cruciate Ligament Reconstruction
(2018-03-02)An anterior cruciate ligament (ACL) injury is one of the most common injuries to the knee joint. It is also one of the most researched areas within sports medicine, orthopedics and physical therapy. The goal of this thesis ... -
The prefrontal cortex and information processing : nitric oxide signaling studied in an animal model of schizophrenia
(2008-11-28)The prefrontal cortex has been extensively linked to several cognitive domains that are severely compromised in schizophrenia. It has therefore become a key region for studies on the disabling cognitive dysfunction commonly ... -
Pregnancy-related pelvic girdle pain management. Tailored physiotherapy treatment strategies anchored in women's experiences and expectations
(2024-01-11)Introduction: Pregnancy-related pelvic pain (PGP) affects over half of all pregnant women. This pain can significantly impact daily activities and limit the ability to move freely, leading to reduced physical activity, ... -
Prodromal Cognitive Signs of Dementia
(2009-04-24)The increase in proportion of elderly worldwide, coupled with the fact that increasing age is a primary risk factor for dementia, have fuelled the efforts to unveil the warning signs of dementia. Although important ... -
Progesterone receptor-mediated effects on apoptosis in periovulatory granulosa cells
(2006-11-28)The most common fate of developing ovarian follicles is demise due to a process known as atresia. Regulation of atresia is dependent on the developmental stage of the follicles, resulting in a continuous reduction of the ... -
Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders
(2008-04-04)ABSTRACT There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact ...