Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 311-330 of 477
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On the use of genomics to assess environmental risks of pharmaceuticals
(2009-12-17)Many drugs are found in the aquatic environment and are therefore a cause for concern. Low concentrations of active ingredients from human pharmaceuticals reach the environment via sewage treatment plants, mainly as a ... -
Optimization of first-line anti-tuberculosis therapy in patients co-infected with HIV
(2021-09-24)Every year over one million people die from tuberculosis. People infected with HIV are significantly more vulnerable to tuberculosis, which is the leading cause of HIV-associated death. The first-line treatment for ... -
Optimization of HIV therapy in patients co-infected with tuberculosis: a pharmacogenetic and pharmacokinetic study of efavirenz in Rwandan adult patients undergoing HIV and tuberculosis co-treatment
(2013-11-27)Tuberculosis (TB) is the most common opportunistic infection among people infected with human immunodeficiency virus (HIV). The co-management of HIV/TB co-infection is prone to multiple drug-drug interactions. In addition, ... -
Oral eflornithine treatment of late-stage human African trypanosomiasis
(2022-11-21)Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African ... -
Orofacial dysfunctions in children and adolescents with myotonic dystrophy type 1 - evaluation and intervention
(2010-05-12)Myotonic dystrophy type 1 (DM1) is a slowly progressive neuromuscular disease. The overall aim of this thesis was primarily to describe the characteristics, prevalence, and development of orofacial functions in a group of ... -
Oropharyngeal dysphagia in adults: Prevalence, professional practices, patient perspectives and treatment outcomes
(2023-05-25)Background: Oropharyngeal dysphagia (OD) is defined as any disruption in the transportation of food/liquids safely and efficiently from the mouth, through the pharynx and into the esophagus. The underlying causes of OD ... -
Orthoptic Findings and Visual Fixation in children in general and in children with surgically treated hydrocephalus
(2007-04-11)Background: The ocular motor system is complex and dependent on the cooperation of many different areas of the brain. Ocular motor functions may be disturbed by various factors resulting in strabismus, and abnormal fixational ... -
Outcome after modern neurosurgical care and formalised rehabilitation following severe brain injury
(2010-05-28)Aims: The overall aims were to evaluate the results of the treatment concepts for severe brain injury including decompressive craniectomy (DC), early rehabilitation and long-term follow-up, primarily according to the ... -
Outcome after treatment of cerebral aneurysms
(2024-02-08)A cerebral aneurysm is a saccular or tubular-like deformity of the arterial vessel wall which is usually thinner. The rupture of a cerebral aneurysm is associated with a high morbidity and mortality by causing an aneurysmal ... -
Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation
(2020-06-12)ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and ... -
Parkinson's disease and motor function - a validation of the PLM method
(2013-09-27)Aim: To validate the Posturo-Locomotor-Manual (PLM) test, an objective movement measurement system designed to measure movement disability in patients with Parkinsonism. Method: The reliability of the PLM test was determined ... -
Participation after stroke in a short- and long-term perspective
(2019-10-15)The main scope of this thesis was to study and describe perceived participation among persons with stroke. In doing so, different timepoints were chosen to make a more complete picture of participation after stroke. The ... -
Pathophysiological regulation of white adipocyte exocytosis of different adiponectin molecular forms
(2019-03-06)In this thesis we have identified mechanisms involved in the exocytosis of different adiponectin molecular forms in health and in metabolic disease. We have also studied similarities and differences in depot-specific ... -
A pathway for pleasant touch: linking peripheral receptors to central processing and hedonic experience
(2009-11-10)This thesis investigates the mechanisms underpinning pleasant touch, describes a pathway from peripheral nerve endings in the skin to the insular cortex, and relates these findings to the subjective hedonic experience of ... -
Patience you must have, my young athlete - Rehabilitation specific outcomes after anterior cruciate ligament reconstruction
(2019-05-07)An anterior cruciate ligament (ACL) injury is one of the most common knee-related injuries, usually occurring in younger individuals during sports participation. Moreover, almost 1 in 4 of younger athletes sustain a ... -
Perinatal Staphylococcus epidermidis infection and the immature brain: a neuroinflammatory link
(2022-05-27)Preterm birth and its associated complications are among the most serious global health issues that modern society faces. Due to the prolonged medical care and immature immune system, preterm infants have a higher ... -
Person-centred care and communication disorders: Exploration and facilitation of conversational interaction involving people with acquired neurogenic communication disorders and health care providers
(2017-05-08)Functional communication is a prerequisite for person-centred care. However, the presence of acquired neurogenic communication disorders makes the delivery of person-centred care challenging for health care providers and ... -
Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT
(2023-11-15)N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the ... -
Pharmacokinetics of artemisinin derivatives in rats, healthy volunteers and patients
(2015-09-04)Malaria is still a major health problem, killing approximately 1,600 people each day. The most vulnerable patient groups are children under the age of five and pregnant women. Artemisinin-based combination therapy is ... -
Physical activity among patients undergoing bariatric surgery
(2013-04-30)The World Health Organization (WHO) recommend that adults should perform ≥150 minutes of moderate intensity physical activity or ≥75 minutes of vigorous intensity physical activity or an equivalent combination of ...