Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 264-283 of 479
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Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2019-08-30)Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired ... -
Muscarinic receptors in the urinary bladder - The role of the urothelium regarding cholinergic and nitrergic effects in inflammation
(2010-11-19)Inflammation alters the functional properties of the urinary bladder. Interstitial cystitis (IC) is a chronic inflammatory syndrome in man that is characterized by urgency, frequency and visceral pain. The overall aim of ... -
Muscle diseases with damaged sarcomeres - causes and consequences
(2011-01-19)Muscle diseases, also called myopathies, are usually defined as diseases where the pathology is confined to the muscle itself. This excludes diseases caused by structural abnormalities in the peripheral nerve, from the ... -
Muscle strength and resistance exercise in women with fibromyalgia - a person-centered approach
(2018-05-15)Fibromyalgia (FM) is characterized by generalized pain and associated with impaired physical capacity and activity limitations. Low-intensity exercise has been shown to be a safe way to exercise without risking an increase ... -
N-acetylaspartate in brain - studies on efflux and function
(2006-10-16)N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The function of NAA is still unsettled in spite of 50 years of research. The mainly neuronal synthesis and glial breakdown of ... -
Natural course and long-term prognosis in idiopathic Normal Pressure Hydrocephalus - the effect of delayed surgery and clinical factors on outcome and survival
(2020-05-07)Idiopathic Normal Pressure Hydrocephalus, iNPH, causes gait and balance difficulties, urinary incontinence and cognitive decline in mainly older persons and is treatable by insertion of a cerebrospinal fluid diverting ... -
Natural History of Human Papillomavirus Infections and Other Sexually Transmitted Infections in Rwanda-Immunological Aspects of the Uterine Cervix
(2018-11-23)Objective: Cervical cancer stands for the predominant cause of cancer death among Rwandan women. Chronic Human Papillomavirus (HPV) infection constitutes the main risk factor. We here assessed the prevalence and incidence ... -
Navigating towards a self-determined daily life in old age. Experiences, instrument evaluation and explanatory factors.
(2015-05-18)Aim: The overall aim of this thesis was to explore self-determination in the context of community-dwelling older persons with different degrees of dependence in daily activities. Methods: Using a qualitative, grounded ... -
Neural circuit mapping af orexigenic systems
(2023-04-21)Orexigenic systems in the brain process appetite and/or hunger information and ultimately coordinate feeding responses. These brain circuits are critical for survival and originally evolved to ensure that we consume ... -
NEURAL STEM/PROGENITOR CELLS IN THE POST-ISCHEMIC ENVIRONMENT: Proliferation, Differentiation and Neuroprotection
(2007-06-04)Stroke is one of the leading causes of chronic disability and death in the Western world. Today, no treatment can repair the cellular loss associated with an ischemic lesion. However, the discovery and dynamic regulation ... -
Neurobehavioral correlates of disinhibitory psychopathology
(2020-11-20)Disinhibitory psychopathology refers to maladaptive behavioral expressions stemming from problems with impulse control. Despite a robust association with antisocial and criminal behavior, knowledge about the neurobehavioral ... -
Neurobiological markers for personality, inflammation and stress: A naturalistic study in knee arthroplastic patients
(2013-03-25)Background: Psychiatry has strived to identify biomarkers elucidating the underlying biological mechanisms behind different disorders, to help in diagnostics and to assess treatment effects. In forensic psychiatric ... -
Neurodevelopmental disorders (ESSENCE): Early detection and outcome in adulthood
(2022-09-02)Objectives: Examine outcomes in adulthood for a group of individuals diagnosed with fetal alcohol spectrum disorders (FASD), and for another group during childhood diagnosed with attention-deficit/ hyperactivity disorder ... -
Neurofilaments as biomarkers of neuronal damage
(2019-09-24)Different neurodegenerative diseases have overlapping symptomatology and pathology and have thus become a challenge to modern medicine to achieve a correct diagnosis. The aim of the thesis was to evaluate the use of ... -
Neuromodulation of hippocampal single cell- and network activity by human cerebrospinal fluid
(2015-11-24)Neuromodulation is a key process determining the function of central neurons. The brain extracellular fluid contains numerous neuromodulatory substances (neuromodulators), but how they collective influence neuronal activity ... -
The neuromodulatory effect of extracellular ions in the central nervous system
(2022-08-23)Neurons are the cells that send and receive signals in the central nervous system. Neuronal signaling is the base for all the complex tasks the human brain is capable of, from the detection of a smell to the composition ... -
Neuronal networks involved in low back pain; experimental studies
(2012-10-08)Low back pain is a common cause of disability, with a lifetime prevalence of up to 80%. A lumbar disc herniation, involving a bulging disc and/or leakage of the intervertebral disc’s nucleus pulposus, may be a possible ... -
New Risk Factors in Poststroke Epilepsy
(2022-05-04)The overall aim of the present research was to identify new risk factors for poststroke epilepsy (PSE). Specifically, we wanted to assess the impact of having a first-degree relative with epilepsy on PSE risk (Paper I), ... -
Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat
(2016-12-14)Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with ... -
Non-invasive ultrasound-based cardiovascular imaging in mouse models of atherosclerosis
(2008-03-18)Atherosclerosis is a chronic multi-factorial vascular disease. It generally requires large clinical settings and over many years to study the disease progression in man. Genetically modified mouse models of atherosclerosis ...