Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 238-257 of 478
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lnternalizing problems in childhood and adolescence: predictive, etiological, and neurodevelopmental aspects
(2021-11-25)Internalizing disorders such as anxiety and depressive disorders are common mental disorders in childhood and adolescence. They are characterized by disordered emotions and moods, causing emotional distress and impairment. ... -
lnvestigating intestinal smooth muscle dysfunction in the 6-OHDA rat model of Parkinson's disease
(2022-05-27)The neurodegenerative progression of the nigrostriatal pathway in Parkinson’s disease (PD) entails the appearance of motor and nonmotor symptoms. Nonmotor symptoms are common, having a negative impact on the quality of ... -
Long-term outcomes of epilepsy surgery - prospective studies regarding seizures, employment and quality of life
(2016-12-09)Epilepsy surgery is a treatment option for selected patients with drug-resistant epilepsy. Patients need individual pre-surgical counselling on chances of seizure freedom and other outcomes in a long-term perspective. The ... -
Long-term outcomes of obsessive-compulsive disorder in children and adolescents
(2019-02-07)Aim: The overall aim of this thesis is to investigate the long-term course and outcome of pediatric OCD following evidence-based treatment of pediatric OCD. Outcome is assessed with regard to severity of OCD symptoms ... -
Long-term post-stroke outcome - the Sahlgrenska Academy Study on Ischemic Stroke
(2014-11-21)Independent studies report that stroke incidence in younger ages is increasing. Consequences after stroke include disability, cognitive dysfunction and the risk of stroke recurrence and coronary events. There are still ... -
Longitudinal cognitive changes in medically and surgically treated patients with drug resistant partial epilepsy
(2010-04-27)When this study was initiated, there were few published longitudinal studies on cognition in medically treated patients with refractory epilepsy, and none included reassessment data from healthy controls. At the time there ... -
Longterm prognosis of multiple sclerosis in untreated patients and in patients treated with first generation immunmodulators
(2014-11-24)The course of multiple sclerosis (MS) is extremely variable. A limited number of demographic and clinical variables at MS onset were described to predict time to the onset of irreversible disability. However, there is no ... -
Machine learning and big data for personalized epilepsy treatment
(2023-05-23)Finding an effective anti-seizure medication (ASM) with minimal side effects is a challenge. Patient characteristics are used to guide treatment selection, but about half of the patients with epilepsy do not achieve seizure ... -
Machine learning for identification of brain activity patterns with applications in gentle touch processing
(2009-10-23)Since the first mention of artificial intelligence in the 1950s, the field of machine learning has provided increasingly appealing tools for recognition of otherwise unintelligible pattern representations in complex data ... -
Mass spectrometric quantification of amyloid-beta in cerebrospinal fluid and plasma
(2015-10-07)Alzheimer’s disease (AD) is the most common neurodegenerative disease among the elderly and accounts for 60-80% of all cases of dementia. Currently, the diagnosis of AD is based on cognitive tests and mental state exams, ... -
Mass spectrometry based proteomic strategies applied in the study of central nervous system derived cells
(2007-03-26)This thesis focuses on evaluation, improvement and development of mass spectrometry based proteomic strategies for identification and quantitation of proteins. Development of such strategies is important to achieve a better ... -
Measuring outcomes following brain tumor surgery: a registry based approach
(2021-05-27)Meningiomas and vestibular schwannomas (VS) are generally slow-growing and benign brain tumors, with low rates of tumor-related mortality. Surgery is rarely the only viable treatment option. In cases where there is no clear ... -
Measuring the tactile sense: Cortical mechanisms and clinical applications of tactile direction discrimination
(2011-03-18)Most of the studies aiming to investigate the human tactile sense are done on the glabrous skin. Still, there is a need for a quantitative method for evaluating nervous function of the hairy skin. Tactile direction ... -
Mechanism of Action of the Antiarrhythmic Agent AZD7009
(2007-01-26)Atrial fibrillation (AF) is the most common tachyarrhythmia in the adult population and is a major cause of morbidity and mortality. AF can be terminated and sinus rhythm restored by prolonging the action potential duration ... -
Mentally disordered offenders: a longitudinal study of forensic psychiatric assessments and criminal recidivism
(2013-08-27)Background: During history, mentally disordered offenders have been in focus regarding responsibility for their crimes and imposition of punishment. The boundary stone of legal consequences for mentally ill offenders has ... -
Metabolic and immunological interactions between adipose tissue and breast cancer - implications of obesity in tumor progression
(2019-10-16)Triple-negative breast cancers have fewer treatment options than other breast cancers. The overall goal of this research is to identify new pharmaceutical targets for triple-negative breast cancer through studies of the ... -
Metabolic and ovarian consequences of perinatal sex steroid programming
(2008-11-24)Endocrine and metabolic disturbances in adulthood may stem from insults such as nutritional and hormonal alterations that occur at critical periods in pre- or postnatal life – a process known as programming. This means ... -
Microglial Glutamate Transporters - Regulation of Expression and Possible Physiological Functions
(2007-05-15)Microglia are considered as the immunocompetent cells of the central nervous system (CNS). Being the first line of defence, they have prominent roles in monitoring the homeostasis and the extracellular milieu and can rapidly ... -
Mild Cognitive Impairment - concepts, cut-offs, and clinical relevance
(2019-04-25)Mild cognitive impairment (MCI) is a diagnosis frequently used in dementia research and in memory clinics. MCI is meant to identify patients without dementia, but with cognitive decline beyond what is considered normal, ... -
Mild intellectual disability: Diagnostic and outcome aspects
(2013-11-29)The aim of the thesis was to describe mild intellectual disability (ID) from various neurodevelopmental and neuropsychiatric perspectives in children and young adults. Paper I The objective of the first paper was to ...