Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 202-221 of 477
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IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice
(2016-01-29)It has previously been shown that mice lacking interleukin-6 (IL-6) develop mature onset obesity. The weight-suppressing effects of IL-6 have been assumed to be exerted at a central level, as supported by the fact that ... -
Imaging of coronary artery function and morphology in living mice - applications in atherosclerosis research
(2007-05-04)Atherosclerosis in the coronary arteries is the major reason for myocardial infarction and cardiovascular death. In the clinic, several imaging systems make it possible to study coronary artery function and morphology ... -
In vitro and in vivo studies of artemisinin endoperoxides
(2014-08-29)Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based ... -
In vitro models of the blood brain-barrier using iPSC-derived cells
(2019-11-18)The blood-brain barrier (BBB) constitutes the interface between the blood and the brain tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain. Models of the BBB are useful for ... -
In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions
(2019-05-23)The adult brain has an inherently low capacity for tissue regeneration, and neurons lost to disease or injuries are normally not replaced. This becomes especially apparent when stroke or brain trauma occurs. The discovery ... -
Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin
(2019-05-07)Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. Sensitive assays for a synaptic protein called neurogranin ... -
Indicators for Behavioral Pain Rehabilitation. Impact and predictive value on assessment, patient selection, treatment and outcome.
(2014-05-05)Chronic musculoskeletal ‘non-specific’ pain is still highly prevalent, despite advances of the biopsychosocial model in pain care and interprofessional rehabilitation. According to national and international reports, one ... -
Induction of the cytoskeletal protein radixin in the adult brain
(2012-11-22)Abstract Neural stem and progenitor cells (NSPCs) proliferate throughout life in two regions of the brain, namely the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of dentate gyrus in the ... -
Inflammation and behavior following irradiation-induced injury in the developing brain
(2009-08-28)Radiotherapy is used in the treatment of pediatric brain tumors and is often associated with debilitating late effects, such as intellectual impairment. Areas in the brain harboring stem cells are particularly sensitive ... -
Inflammation and Cell Profileration Following Perinatal Brain Injury
(2010-08-30)Inflammation plays an important role in cerebral ischemic injury in the immature brain. The aim of the thesis was to investigate (1) the role of astrocyte activation and reactive gliosis in neonatal hypoxic-ischemic (HI) ... -
Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury
(2008-05-13)Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, ... -
Inflammation in experimental neonatal brain injury and in a clinical study of preterm birth; involvement of galectin-3 and free radical formation
(2010-01-08)Introduction; Intrauterine infection/inflammation is associated with preterm delivery (PTD) and severe neonatal morbidity. Inflammation is also important in the secondary neurotoxic cascade leading to perinatal brain injury. ... -
Inflammation in the immature brain: The role of Toll like receptors
(2011-10-28)Infection/inflammation and/or hypoxia-ischemia (HI) are major causes of perinatal brain injury. Toll-like receptors (TLRs), important components of innate immunity, have been shown to be involved in brain injury, both after ... -
Influence of serotonin on anxiety-like behavior in rat
(2018-11-05)It is well-established that serotonin is involved in the regulation of mood and behaviour, partly implied by the therapeutic effect of prolonged treatment with selective serotonin reuptake inhibitors (SSRI) on mood and ... -
Influence of serotonin-related genes on behavior and body weight
(2008-05-06)Rationale: The neurotransmitter serotonin has been implicated in the regulation of normal behaviors, including food intake, and attributed importance for a variety of common psychiatric conditions, including major depression, ... -
Interactions between nutrition, obesity and the immune system
(2009-11-22)There are several links between body fat and the immune system. For example, mice lacking activity of the pro-inflammatory interleukin-(IL)-1 and IL-6 develop obesity. Conversely, obesity is associated with adipose tissue ... -
Internationally adopted children with unilateral cleft lip and palate - longitudinal perspectives on speech production and language ability
(2020-05-13)Many children with cleft lip and palate have been adopted to Sweden. Most had had no palatal closure performed in their native countries and received their first palatal surgery in Sweden while acquiring a new first language. ... -
Intracranial Arachnoid Cysts. Epidemiology, Morphology and Surgical Outcome
(2016-05-13)Background: Intracranial arachnoid cysts (AC) are malformations of the arachnoid membrane. They may cause symptoms, either by obstruction of the CSF flow or by compression of adjacent neural tissues. The aim of this thesis ... -
Intracranial volume in neuroimaging: estimation and use in regional brain volume normalization
(2019-02-15)The aim of this thesis is to validate methods for estimation of intracranial volume in magnetic resonance images and to improve our understanding of the effect of intracranial volume normalization. To achieve the first ... -
Investigation of the pathophysiology of progression in multiple sclerosis: studies on cerebrospinal fluid biomarkers
(2013-04-23)Multiple Sclerosis (MS) is considered an autoimmune disease of the central nervous system (CNS). It usually starts with a relapsing remitting (RR) course that eventually transforms into progressive (P)MS, showing ...