Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 107-126 of 477
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Creating opportunities for cultural awareness in occupational therapy: An example from Latin America
(2016-05-09)Aim: to explore how awareness of cultural issues is being applied within occupational therapy to address some of the challenges relating to professional education and practice. Methods: In Study I an integrative literature ... -
CSF biomarker panels. Focus on synaptic pathology
(2022-08-18)Fluid biomarkers of neuropathological features are important clinical tools in diagnostics and patient monitoring of neurodegenerative diseases. For the most prevalent cause of dementia, Alzheimer’s disease (AD), several ... -
CSF biomarkers in idiopathic normal pressure hydrocephalus- Diagnostics and pathophysiology
(2019-05-23)Idiopathic normal pressure hydrocephalus (iNPH) is a disease of the elderly with enlarged ventricles despite a normal CSF pressure. Clinically, iNPH presents with gait- and balance disturbances, cognitive decline and ... -
CSF biomarkers reflecting beta-amyloid and axonal pathology in Alzheimer's disease and related conditions
(2011-11-18)Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and ... -
Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease
(2008-08-25)Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson’s disease (PD), and is known to generate reactive oxygen species (ROS), ... -
Cytochrome P450 enzymes affected by artemisinin antimalarials-pharmacokinetic and pharmacogenetic aspects
(2008-11-03)With more than 500 million cases and at least 1 million deaths each year, malaria is a major global health problem. The main problem with malaria control is the emerging drug resistance among parasites causing the infection. ... -
Cytokines and lipids in pregnancy – effects on developmental programming and placental nutrient transfer
(2010-08-12)Metabolic disturbances, in particular those associated with nutritional challenges, that take place during development, both in utero and early postnatal life, have long-lasting health consequences on an individual. The ... -
Cytokines in Metabolic Functions
(2008-02-28)During infections, circulating cytokines are largely produced by immune cells. In healthy obese individuals, large parts of these circulating cytokines are produced in adipose tissue, for instance by macrophages that have ... -
Defense-related inhibition of sympathetic nerve activity: Insights from neuroimaging and monozygotic twins on related cortical processes and clinical potential
(2021-05-27)This thesis investigates a physiological phenomenon observed in the peripheral sympathetic nervous system in response to various stressors and tries to bring it closer to clinical research. Sudden surprising stimulation ... -
Dementia and other mental disorders among 95-year olds
(2008-04-17)The aims of this study were to estimate the prevalence of mental disorders and age related differences in the very elderly. In addition, five-year mortality after age 95 in relation to dementia and cognitive function in ... -
Dendritic cells in cancer immunotherapy
(2011-02-16)Dendritic cells (DCs) play a central role in the initiation and regulation of innate and adaptive immune responses and have increasingly been applied as vaccines for cancer patients. Ex vivo generation and antigen loading ... -
Depression among Swedish 70-year-olds - Sex differences from a gender perspective
(2020-04-28)Depression is one of the leading causes of global burden of disease. Due to increased life expectancy, late-life depression is an escalating public health issue. The prevalence is reported to be almost twice as high among ... -
Derivation, propagation and differentiation of human stem and progenitor cells
(2009-08-17)Neuronal loss is a common feature of many neurological disorders, including stroke, Parkinson’s disease, Alzheimer’s disease and traumatic brain injury. Human embryonic stem cells (hESCs) and hESC-derived neural progenitors ... -
Deriving biomarkers from computed tomography using deep learning
(2022-09-23)X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are widely used structural neuroimaging modalities. For brain atrophy assessment and volumetric quantification using automated methods, MRI is the preferred ... -
Developing brain and systemic inflammation: a "Toll-like" link with consequences
(2017-05-24)The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. ... -
Development and validation of upper extremity kinematic movement analysis for people with stroke. Reaching and drinking from a glass.
(2013-11-18)Kinematic analysis is a powerful method for objective assessment of movement performance, and is increasingly employed as outcome measure after stroke. The number of studies investigating natural, goal-oriented daily tasks ... -
Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease
(2020-05-18)Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ plaques is one of the major neuropathological features of AD. However, Aloysius ... -
Development of nursing programme to assist medical treatment in early onset Alzheimer's disease
(2013-01-25)Alzheimer´s disease (AD) is accompanied by neural degeneration with loss off dendrites and synapses. The ganglioside GM1 has been shown, but not in AD, to have positive influence on the nerve cells and stimulate growth of ... -
Developmental plasticity of the glutamate synapse: Roles of low frequency stimulation, hebbian induction and the NMDA receptor
(2010-01-26)The glutamate synapse is by far the most common synapse in the brain and acts via postsynaptic AMPA, NMDA and mGlu receptors. During brain development there is a continuous production of these synapses where those partaking ... -
Diagnostic Methods in Traumatic Brain Injury
(2017-04-20)Background: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Early detection and quantification of TBI is important for acute management, for making early accurate prognoses of outcome, and ...