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Health conditions, functioning and social outcomes in adults with cerebral palsy
(2024-02-21)Background: A majority of individuals with cerebral palsy (CP) are adults, and yet healthcare and research are focused on children. In comparison to the consequences in childhood, little is known about the long-term ... -
Health-promoting intervention for community-dwelling older adults - Focusing on the concept of frailty and intervention outcome
(2012-02-03)Aim: The overall aim of this thesis was to increase our understanding of the concept of frailty in relation to older adults, and to review and evaluate outcomes in health-promoting interventions for community-dwelling older ... -
Hearing and middle ear status in children and young adults with cleft palate
(2013-02-27)Objective: The overall aim of this thesis was to define the hearing and prevalence of abnormal middle ear status across childhood and into young adulthood and attempt to understand the effects of a higher prevalence of ... -
Hearing in advanced age Epidemiological, pathophysiological, and diagnostic perspectives from the Gothenburg H70 Birth Cohort Studies
(2023-10-16)The population aged 80 and above is expected to increase in the future resulting in an anticipated rise in health care demands. Age-related hearing loss (ARHL) is described as the third most common health condition ... -
Hearing in early old age: current perspectives
(2021-02-08)Age related hearing loss is a public health concern that restricts the possibilities of older persons to lead a healthy, social and active life. The present thesis aims to provide contemporary perspectives on age related ... -
Hearing symptoms in children and adolescents - Tinnitus and temporary threshold shift
(2013-04-10)This thesis has assessed the prevalence of spontaneous tinnitus (ST), noise-induced tinnitus (NIT) and temporary threshold shift (TTS) in children and adolescents as well as investigated some of the audiometric, medical ... -
Hereditary diffuse leukoencephalopathy with spheroids: Insights into an adult onset neurodegenerative disease
(2013-03-25)During the last three decades, the areas of inherited white matter (WM) disorders have expanded. Advances in magnetic resonance imaging (MRI) and genetics have led to increased detection of adult-onset WM disorders. ... -
Herpes virus retinitis - clinical and virological characteristics
(2023-04-19)In this thesis, we first aimed to determine whether there may be herpes virus deoxyribonucleic acid (DNA) in the aqueous humour of asymptomatic individuals (paper II). Presence of herpes simplex virus (HSV), varicella ... -
Hippocampal volumetry in mild cognitive impairment
(2010-09-10)Dementia is a syndrome with cognitive decline as a prominent feature. MCI is similarly a syndrome of cognitive decline, albeit with much subtler symptoms, and has been identified as a condition at risk for progression to ... -
How to support knowing and doing in promotion of health - Lessons learned from the Promoting Aging Migrants' Capabilities program
(2016-11-23)Worldwide, the number of persons aging in the context of migration increases. Aging and migration can influence a persons’ opportunities to experience health. There is a need to develop knowledge of how to facilitate ... -
Human iPSC-derived neuronal networks. Development and application for compound evaluation
(2022-02-03)Research on human brain development and function in health and disease has been hampered by limited access to primary human tissue and limited translatability of animal studies. This knowledge gap is encouraging the use ... -
IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice
(2016-01-29)It has previously been shown that mice lacking interleukin-6 (IL-6) develop mature onset obesity. The weight-suppressing effects of IL-6 have been assumed to be exerted at a central level, as supported by the fact that ... -
Imaging of coronary artery function and morphology in living mice - applications in atherosclerosis research
(2007-05-04)Atherosclerosis in the coronary arteries is the major reason for myocardial infarction and cardiovascular death. In the clinic, several imaging systems make it possible to study coronary artery function and morphology ... -
In vitro and in vivo studies of artemisinin endoperoxides
(2014-08-29)Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based ... -
In vitro models of the blood brain-barrier using iPSC-derived cells
(2019-11-18)The blood-brain barrier (BBB) constitutes the interface between the blood and the brain tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain. Models of the BBB are useful for ... -
In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions
(2019-05-23)The adult brain has an inherently low capacity for tissue regeneration, and neurons lost to disease or injuries are normally not replaced. This becomes especially apparent when stroke or brain trauma occurs. The discovery ... -
Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin
(2019-05-07)Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. Sensitive assays for a synaptic protein called neurogranin ... -
Indicators for Behavioral Pain Rehabilitation. Impact and predictive value on assessment, patient selection, treatment and outcome.
(2014-05-05)Chronic musculoskeletal ‘non-specific’ pain is still highly prevalent, despite advances of the biopsychosocial model in pain care and interprofessional rehabilitation. According to national and international reports, one ... -
Induction of the cytoskeletal protein radixin in the adult brain
(2012-11-22)Abstract Neural stem and progenitor cells (NSPCs) proliferate throughout life in two regions of the brain, namely the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of dentate gyrus in the ... -
Inflammation and behavior following irradiation-induced injury in the developing brain
(2009-08-28)Radiotherapy is used in the treatment of pediatric brain tumors and is often associated with debilitating late effects, such as intellectual impairment. Areas in the brain harboring stem cells are particularly sensitive ...