Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 46-65 of 478
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BACK TO ONESELF Sensory Motor Learning applied in patients with nonspecific chronic low back pain
(2009-12-04)Back pain is an endemic problem affecting one in five adults every year. Even though only 10 % of all cases of back pain become chronic it is one of the largest health problems in industrialized societies. The term nonspecific ... -
Behavior and cytogenesis following irradiation or isoflurane exposure to the developing brain
(2010-08-30)In this thesis, the effects of an anesthetic agent, isoflurane, on the young brain and resulting behavioral effects were investigated. Anesthesia is commonly used in young children during surgery or other procedures ... -
Bestrophin-3: Localization and function in normal and injured tissues
(2015-02-05)Bestrophin-3 (Best3) is a protein with multiple functions. It can constitute a calcium-activated chloride channel when overexpressed in cultured cells, but the function of Best3 is not well studied in cells in situ. Recently ... -
Biochemical markers in dementia - Exploring Swedish registry data and the human proteome
(2019-09-04)Cerebrospinal fluid (CSF) biomarkers of neurodegenerative diseases have a wide scope of applications in diagnostics, prognosis assessment, disease staging, treatment evaluation and more. In this PhD project we aimed to ... -
Biomarkers for Alzheimer's disease and the APOE polymorphism
(2019-04-18)Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) ... -
Biomarkers in Multiple Sclerosis - Monitoring disease activity and treatment afficacy
(2018-03-21)The pathophysiology of multiple sclerosis (MS) is complex with the presence of inflammation and neurodegeneration in all stages of the disease. The disease course, treatment response and outcome are highly variable in MS. ... -
Bipolar disorders: Subtypes, treatments, and health inequalities
(2020-02-18)This thesis comprises five studies based on prospective, longitudinal data from the Swedish national quality register BipoläR. Study I examined the differences between bipolar subtype I and II with respect to clinical ... -
Blood and CSF biomarkers for investigation of the immunopathogenesis of relapse in Multiple Sclerosis
(2008-02-15)Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). MS usually starts with a relapsing-remitting course (RRMS) that later converts into a secondary progressive phase (SPMS). While inflammation ... -
Blood biomarkers for traumatic brain injury
(2015-11-13)Traumatic brain injury (TBI) is the major cause of death and disability following blunt head trauma. The term mild TBI (mTBI) or concussion are used interchangeably in the literature. Concussion or mTBI is recognized as a ... -
Blood Vessels, Biomarkers, and Broken Barriers: lnvestigations of the Brain Vasculature in Models of Neonatal Brain lnjuries
(2022-02-10)Brain injury during the perinatal period can lead to lifelong impairment in cognitive and motor function, or an early death. Term neonatal encephalopathy and preterm germinal matrix haemorrhage are two conditions that can ... -
Body composition in women of reproductive age and during pregnancy. Method comparisons and gestational changes
(2018-03-28)Body composition measurements can contribute to assessment of nutritional status, both for clinical use and for research purpose. During pregnancy, body composition measurement is complicated by decreased density of the ... -
Body fat regulating neuropeptides: relation to interleukines and gut microbiota
(2012-05-25)Previous studies have shown that mice lacking interleukin-6 (IL-6), an important cytokine in the immune system, develop obesity, and that central, but not peripheral, administration of IL-6 induces energy expenditure. These ... -
Boys with Asperger Syndrome grown up. A longitudinal follow-up study of 100 cases more than 5 years after original diagnosis
(2007-03-09)Introduction and aims: In 1981, the diagnostic label of Asperger Syndrome (AS), was coined after the Austrian paediatrician Hans Asperger, by the English psychiatrist Lorna Wing, who reintroduced his 1944 work about “die ... -
Brain glycine receptors as a common target for alcohol and the relapse-preventing drug acamprosate - a preclinical study
(2011-03-08)Alcohol abuse and dependence make up the most prevalent categories of substance use disorders in the world. Converging evidence from the current research group has identified two receptor populations, the glycine (GlyRs) ... -
Brain mechanisms for skin stroking processing in healthy subjects and anorexia nervosa patients
(2016-12-01)Functional magnetic resonance imaging (fMRI) allows us to study brain processing of inputs from sensory neurons both at the level of single brain areas but also at the level of larger brain networks. In this thesis we ... -
Brain Regeneration - in vitro and in vivo studies of exercise-related effects on brain plasticity
(2008-06-13)Neural stem and progenitor cells in the germinal regions of the adult brain, such as the hippocampus, are of great interest, because they provide the possibility for enhanced brain plasticity or can contribute to endogenous ... -
Bringing MEG towards clinical applications
(2018-08-21)Magnetoencephalography (MEG) is a passive, non-invasive functional neuroimaging technique for recording magnetic fields generated by neuronal currents in the brain. MEG provides a unique capability to map the electrophysiology ... -
Candidate biomarkers for synaptic pathology: neurogranin, neuroligins and neurexins in neurodegenerative disorders
(2021-05-14)Synapses are small units through which neurons communicate in the brain. They represent the site of memory formation and cognitive abilities and are thus primarily affected by neurodegenerative diseases such as Alzheimer’s ... -
Capturing the experience of health among persons aging in a migration context - Health promotion interventions as means to enable health and occupations in daily life
(2018-09-28)Aim: The overall aim of this thesis was to increase our understanding of health in everyday life among older persons aging in migration, and to evaluate the outcome of a health promotion intervention on sense of coherence, ... -
Cardiometabolic risk indicators in bipolar disorders
(2023-05-15)In addition to disabling mood episodes, bipolar disorders (BDs) predispose individuals to high cardiovascular disease (CVD) risk. This thesis explores the association between BDs and the metabolic risk indicators body mass ...