• Non-functioning pituitary adenomas and hypopituitarism - studies on morbidity and mortality 

  Hammarstrand, Casper

  Background and aims: Hypopituitarism is most commonly caused by benign pituitary tumors, often resulting in insidious symptoms that develop over a long time. Due to either a mass effect exerted by the tumor, or due to the ...

• The role of galectin-1 in type 2 diabetes. Clinical and experimental studies 

  Fryk, Emanuel

  Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes. Study I: Through a combination of microdialysis and ...

• The endocrine system in the progression of mild cognitive impairment to dementia 

  Quinlan, Patrick

  Background and aims: Endocrine alterations have been related to cognitive decline, but the role of hormones may vary along the progression to manifest dementia. The overall aim of this thesis was to assess whether thyroid ...

• Exploring small airways using breath analyses 

  Viklund, Emilia

  Background: Airway irritants such as allergens, tobacco smoke and viruses may cause damage in the small airways, usually undetected with routine diagnostic methods. Analyses of endogenously produced nitric oxide (NO) and ...

• Occupational heat exposure and kidney disease - Studies on the role of heat stress in the Mesoamerican epidemic of Chronic Kidney Disease of non-traditional origin 

  Hansson, Erik

  This thesis examines the association between heat stress and kidney disease in Mesoamerica using different perspectives and methods. An ecologic study found that hot, sugarcane-cultivating regions had elevated chronic ...

• Nutritional impact on health in patients with Rheumatoid Arthritis 

  Hulander, Erik

  Objective: Rheumatoid Arthritis (RA) is the most common autoimmune rheumatic disease, affecting around 0.5-1% of the population. The aim of this thesis was to study dietary impact on markers of health in patients with ...

• Allergic and non-allergic asthma: Translational research in immunology 

  Boberg, Emma

  Asthma is a chronic heterogeneous respiratory disease affecting more than 300 million people globally. The different phenotypes, including allergic and nonallergic asthma, are driven by different underlying mechanisms ...

• Defining the clinical usefulness of vertebral fracture assessment 

  Johansson, Lisa

  Objective: Vertebral fractures (VFs) are the most common osteoporotic fracture and among the strongest predictors for future fracture. VFs can be identified by vertebral fracture assessment (VFA) from lateral spine imaging ...

• Acromegaly - Mortality, Morbidity and Treatment Patterns 

  Esposito, Daniela

  Background: Acromegaly is a systemic disease associated with multiple comorbidities. The clinical characteristics of acromegaly develop insidiously over several years and the diagnosis is usually delayed. Progress has been ...

• Hypertension, atherosclerosis and fracture risk - observational investigations with focus on antihypertensive therapy 

  Bokrantz, Tove

  Aim: To investigate associations between hypertension, arteriosclerotic disease, and fracture risk in adults and the elderly, with a certain focus on how specific antihypertensive drug treatments in patients with high blood ...

• Clinical challenges in Cushing's syndrome 

  Papakokkinou, Eleni

  Cushing’s syndrome (CS) is caused by prolonged exposure to cortisol excess. CS is associated with cardiovascular diseases, infections, and fractures, as well as with cognitive impairment and affective disorders. This thesis, ...

• Cause-Specific Mortality and Physical Fitness in Mental Disorders - Epidemiological and Internventional Studies 

  Henriksson, Malin

  Mental illnesses are common and constitute a substantial health-related and financial burden on both the individual and society. Mental disorders in general have increased risk of somatic morbidity. An early age of onset ...

• Hypertoniscreening - Tidig upptäckt av högt blodtryck via tandvården 

  Andersson, Helen

  Background: Hypertension is the main risk factor for the world’s total disease burden. This is of significance for public health at national level, for healthcare professionals, resource consumption and costs as well as ...

• Thymic exosomes - effects on selection and maturation of thymocytes 

  Lundberg Wiraeus, Vanja

  T cell tolerance is primarily shaped in the thymus, through direct and indirect presentation of self-antigens to developing T cells. Medullary thymic epithelial cells (mTECs), producing and expressing self-antigens, together ...

• Health locus of control, depressive symptoms, and insulin resistance. Implications for treatment and prevention in general population and primary care 

  Eriksson, Maria CM

  The disease burden of type 2 diabetes and depression is large and challenging for healthcare systems. Preventive interventions require resources and better knowledge concerning early stages in the development of these ...

• The role of the gut microbiota in central energy balance regulation 

  Christina N., Heiss

  The gut microbiota can affect development and metabolism in the host. Today, much is still unknown regarding the effects of the gut microbiota on central energy balance regulation. We used mouse models to determine the ...

• Prognosis and clinical outomes in stroke patients with transcatheter closure of an atrial shunt 

  Alexia, Karagianni

  Background: The percutaneous transcatheter closure of a patent foramen ovale (PFO) after a cryptogenic cerebrovascular event (CVE) has been performed for more than two decades. In contrast with previous randomized studies, ...

• Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes 

  Henninger, Josefin (2022-02-08)

  ABSTRACT Aims The overall aim of this doctoral thesis was to further examine the anthropometric, metabolic and adipose tissue dysfunctions, as well as explore novel metabolites, associated with type 2 diabetes mellitus ...

• Unmet need for mental healthcare among men Sweden: Gendered pathways to care 

  Blom, Sara (2022-02-02)

  Aim: Depression and anxiety disorders have a lifetime prevalence of about 10% among men in high-income countries but many do not seek and receive the care that they need. The aim of this thesis was to explore gendered ...

• Predictors of bone fragility in older women. Associations in older women between risk medications and measurements of physical function, bone microstructure and fracture risk 

  Larsson, Berit (2021-12-20)

  Bone fragility with fractures constitutes a growing public health concern, resulting in suffering and major health care cost. This thesis project has been carried out by means of studies based on the SUPERB cohort of ...

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