Doctoral Theses / Doktorsavhandlingar Institutionen för medicin
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Assessment and management of respiratory tract infections in primary care
Background: Respiratory tract infections (RTIs) are common causes of primary care visits and range from benign to life-threatening. Avoiding the overuse of antibiotics, which can lead to antimicrobial resistance, necessitates ... -
Epidemiological aspects of health and work ability in the Swedish workforce
(2024-03-25)Background: Many working-age individuals suffer from health issues, impacting their work ability and potentially leading to early workforce exit. More understanding of individual and occupational factors influencing work ... -
The role of insulin-like growth factor-l in Alzheimer's disease and vascular dementia
(2024-03-25)Background and purpose: Insulin-like growth factor-I (IGF-I) is involved in normal brain function, but little is known whether IGF-I activity affects the cognitive continuum of dementing disorders. The overall purpose of ... -
Humoral lmmune Response with Focus of lgG Glycosylation -In murine models
(2024-03-14)The humoral immune system orchestrates a vital defense mechanism through the secretion of antibodies, especially Immunoglobulin G (IgG), which actively targets and neutralizes foreign particles and pathogens. Glycosylation ... -
Trends and determinants for graft survival among kidney transplanted patients in Sweden
(2024-02-07)According to literature, even after a successful kidney transplantation approximately 50% of the patients risk losing the transplant within ≈15 years. A return to dialysis or a new transplantation is then necessary. ... -
Parathyroid Hormone Hyper- and Hypoparathyroidism Effect of Treatment and Long-term Follow-up Studies
(2024-01-10)Background: High or low parathyroid hormone (PTH) can be challenging in diagnosis and treatment. The prevalence and natural history of normocalcemic hyperparathyroidism (nHPT) are still not known. The knowledge gap regarding ... -
Development of Automated Algorithms for Epicardial Adipose Tissue Analysis in Computed Tomography and their Application in Population Based Research
(2023-12-22)The epicardial adipose tissue (EAT), which surrounds the heart and is separated from other tissues only by the thin layers of the pericardium, has enjoyed intense research for the past decades. Increased inflammatory ... -
Endogenous and microbial modulators of inflammation
(2023-12-05)Cardiometabolic disease is characterized by dysregulated, chronic inflammation, that may result from impaired resolution pathways or alterations in the gut microbiota. Thus, restoring specialized pro-resolving mediators ... -
Diet as a complementary therapy in Rheumatoid Arthritis - On the menu: An anti-inflammatory portfolio diet
(2023-11-27)Over the last two decades, pharmacological treatment in rheumatoid arthritis (RA) has evolved remarkably and is essential to suppress disease progress. Still, it often fails to provide satisfactory symptom relief suggesting ... -
New sensitive and specific methods for sex steroid measurements in rodent serum and tissues
(2023-11-23)Accurate measurement of sex steroids (androgens, estrogens, and progesterone) is essential in research and clinical settings for common diseases including osteoporosis, prostate cancer, breast cancer, and cardiovascular ... -
The interplay between bile acids and gut microbiota in metabolic and hepatobiliary disease
(2023-11-21)The gut microbiota, a metabolic regulator, orchestrates the production of bioactive metabolites such as secondary bile acids. Growing evidence suggests that shifts in the gut microbiota composition are linked to metabolic ... -
Venous thromboembolism: Risk factors, comorbidities, and treatment-associated risk of bleedings
(2023-11-16)Background: Venous thromboembolism (VTE) is the third most common cardiovascular disease, consisting mainly of deep vein thrombosis (DVT) and pulmonary embolism (PE). Since VTE often is a preventable disease, knowledge of ... -
Diabetes complications, risk factors, and glycaemic indices in persons with type 1 diabetes
(2023-11-09)Background: Persons with type 1 diabetes are at higher risk of cardiovascular disease and mortality. An important risk factor for diabetes complications is hyperglycaemia. Hyperglycaemia has traditionally been measured ... -
Pharmacological therapy in obstructive sleep apnea - Methodology and interventional aspects of carbonic anhydrase modulation
(2023-11-08)BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent disease with potential severe short- and long-term consequences such as daytime sleepiness and cardiovascular disease. Recurrent total or partial collapse of ... -
Platelet inhibition and secondary prevention in cardiac surgery patients
(2023-11-06)ABSTRACT Background and objective Coronary artery bypass grafting (CABG) is the most common cardiac surgery procedure. Dual antiplatelet therapy (DAPT) reduces the risk for ischaemic events in patients with acute ... -
Glucocorticoid-induced adrenal insufficiency
(2023-11-02)Background: Glucocorticoids (GCs) are effective in treating many diseases and are widely used. However, glucocorticoid treatment can down-regulate the hypothalamic-pituitary-adrenal axis and lead to glucocorticoid-induced ... -
Repolarization studies in the long QT syndrome
(2023-10-26)ABSTRACT Background: Sudden cardiac death in the young is predominantly caused by inherited cardiac conditions. Long QT syndrome (LQTS) is one of the most common of these disorders. Since risk stratification relies largely ... -
Sleep apnea and atrial fibrillation: cause or comorbidity?
(2023-10-19)Background: Obstructive sleep apnea (OSA) and atrial fibrillation (AF) are common conditions, associated with morbidity and mortality. Both OSA and AF often go undetected. It has been suggested that OSA may be a modifiable ... -
Androgens and progesterone in tissues and the gastrointestinal tract - Mapping of tissue-specific sex steroid levels in mice
(2023-10-16)Sex steroids such as androgens can exert both positive and negative effects in tissues and are important in physiology and pathophysiological states of men and women. Androgens originate mainly from the gonads. Local ... -
Outcomes of invasive treatment in chronic limb-threatening ischaemia
(2023-10-03)Background In chronic limb-threatening ischaemia (CLTI), obstruction of the arterial blood flow causes ischaemic rest pain, ulcers or gangrene in the lower extremities. Patients with CLTI have a substantial risk of ...