Doctoral Theses / Doktorsavhandlingar Institutionen för medicin
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Cardiopulmonary Phenotyping during Sleep - Innovative Signal Processing for Precision Medicine in Sleep Apnea
(2024-12-18)Background: Obstructive sleep apnea (OSA) is one of the most common sleep disorders with a significant impact on public health. Various studies suggest that the contemporary methods of clinical sleep medicine are ... -
Translational studies to understand myocardial stunning in acute myocardial infarction
(2024-12-18)Myocardial stunning is a reversible contractile dysfunction that persists despite the resolution of myocardial ischemia. It is commonly associated with acute myocardial infarction. However, myocardial stunning also occurs ... -
Human B-cell development at the single-cell level
(2024-11-21)B cells play an integral part of our immune system. In adults they develop in the bone marrow in a regulated process in which the specificity of their B-cell antigen receptor (BCR), a membrane bound antibody, is established. ... -
Characterization and impact of disorders of gut-brain interaction: a national and international epidemiological project
(2024-11-19)Disorders of gut-brain interaction (DGBI) are highly prevalent conditions, characterized by chronic or recurrent gastrointestinal (GI) symptoms. DGBI significantly impacts quality of life (QoL) and healthcare utilization, ... -
DNA damage in autoimmunity
(2024-11-18)Rheumatoid arthritis (RA) is the canonical autoimmune disease whose pathogenesis is tightly linked to risk factors which cause damage of DNA and affect immune cell function. DNA damage abnormally reorganizes the genome and ... -
Tobacco control policies in Vietnam: Smoking behaviors and stakeholders' perceptions
(2024-11-18)Tobacco remains a significant public health concern in Vietnam, particularly among men, with over 15 million users. It has been 12 years since the tobacco control law was enacted; however, the smoking prevalence has decreased ... -
The social determinants of self-reported mental health among adolescents in Sweden and the Nordic countries - focusing on socioeconomic inequalities
(2024-11-14)Mental health problems have increased among children and adolescents in the Nordic countries during the last decades. Such problems may have both short- and long-term negative consequences for both the individual and society ... -
Sudden cardiac arrest in relation to exercise
(2024-11-07)Background: In predisposed individuals with a known or unknown cardiovascular disease, the risk of a sudden cardiac arrest is increased during and immediately after exercise. The most common postmortem diagnosis of ... -
Identifying predictors of long-term effects of bariatric surgery - Analysis of samples and data from the Swedish Obese Subjects (SOS) study
(2024-11-06)Aim of the thesis: To identify predictors of long-term treatment outcomes after bariatric surgery. Material and methods: The Swedish Obese Subjects (SOS) study is a prospective controlled intervention study comparing ... -
Synovial fibroblast activation in rheumatoid arthritis - Role of disease-associated risk genes and effects of methotrexate
(2024-11-06)The overall aim of this thesis was to increase the knowledge of molecular mechanisms shaping the pathogenic phenotype of activated fibroblast-like synoviocytes (FLS), which are drivers of chronic inflammation and destruction ... -
Impact of JAK-inhibition on infections
(2024-11-06)With the growing arsenal of treatment options for immune modulation come great opportunities to help patients. However, tampering with immune cells and their various mediators is also associated with risk, including increased ... -
Person-centered collaboration in the sick leave and rehabilitation process - in a primary care context
(2024-10-31)Aim: This thesis focuses on chronic illness and long-term health-related impairments in work ability, with the overarching aim of expanding knowledge about the sick leave and rehabilitation process (SRP) to support primary ... -
Primary Aldosteronism; a growing challenge
(2024-10-29)Primary aldosteronism (PA), caused by excessive aldosterone production, is a frequently overlooked cause of hypertension. Cardiovascular complications are more common in patients with PA than patients with essential ... -
Cardiometabolic disease and cancer. Effects of body weight and diabetes
(2024-10-23)Background: The rise in overweight and obesity rates is associated with an increase in various forms of cardiovascular disease (CVD) and cancer. Moreover, an increasing proportion of young people with diabetes have type 2 ... -
Aortic Dissection in Turner Syndrome - Risk factors and Long-term Outcomes
(2024-10-23)Background: Turner syndrome (TS) affects 1/2500 live born girls and is caused by a complete or partial loss of an X chromosome. It is characterized by short stature, ovarian dysfunction, congenital heart disease and an ... -
Targeting Glutathione metabolism in cancer - a new therapeutic approach
(2024-10-14)Antioxidants have long been considered as potential cancer-preventive agents, though most clinical trials have failed to demonstrate significant benefits from antioxidant supplements. Recent scientific findings, however, ... -
Frailty in Older Adults in China -Trajectories, Determinants, and Impacts on Healthcare Utilization and Mortality
(2024-09-26)Frailty, though not a disease in itself, often precedes the onset of illness and is frequently overlooked. Research has paid insufficient attention to frailty as a dynamic phenomenon, particularly its longitudinal changes. ... -
Determinants and risk factors for early risk stratification and optimal secondary pevention in ischemic heart disease
(2024-09-26)Background: Ischemic heart disease is the leading cause of death globally. To combat ischemic heart disease and its challenges we must improve secondary prevention for those already affected and prevent its onset in a ... -
Bacterial and Host Factors in Staphylococcus aureus Septic Arthritis
(2024-09-23)The intense battle against Staphylococcus aureus (S. aureus) infections, along with the ongoing struggle to develop new effective treatments, presents a major challenge for the healthcare system. This highly pathogenic ... -
Role of Gremlin1 and Bone Morphogenic Protein 4 (BMP4) in metabolic diseases
Gremlin1, a protein highly expressed in human adipocytes, plays a key role in the differentiation of precursor cells into white adipose tissue and is linked to insulin resistance in hypertrophic obesity. This study ...
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