Background: Obesity is a complex, multifactorial chronic disease linked to severe co-morbidity, reduced quality of life, and lower life expectancy. Despite numerous treatment options, sustained long-term weight loss remains ...

B cells are central components of the adaptive immune system. On their surface, they express a B-cell receptor (BCR), a membrane-bound form of an antibody. Upon activation, B cells differentiate into either antibody-secreting ...

Background: Endovascular aortic repair has better short-term survival than open surgical repair but this advantage is lost over time. The main cause is rupture after EVAR. Its incidence has not decreased despite efforts ...

Background: Noncommunicable diseases (NCDs) are the leading cause of death worldwide, with cardiovascular diseases (CVDs) being the largest contributor. Seventy-three percent of NCD deaths occur in low- and middle-income ...

Abstract Osteoporosis causes significant morbidity and healthcare costs through fragility fractures, with substantial gaps remaining in fracture risk assessment, particularly in older women. This thesis presents four ...

Extracellular vesicles (EVs) are nanosized particles released by human and mammalian cells. They are emerging as therapeutic platforms due to their ability to facilitate intercellular communication and their immunomodulatory ...

Even when treated, 30-day survival after cardiac arrest is low for in-hospital cardiac arrest (IHCA) (15-35%) and out-of hospital cardiac arrest (OHCA) (8%). In this thesis we aimed to investigate factors that affect ...

Background The burden of cardiovascular diseases (CVD) and its risk factors are increasing among adolescents. The life course approach to CVD prevention necessitates targeted intervention among adolescents. Aims This ...

Background: Sick leave with psychiatric diagnoses has increased markedly in Sweden over the past two decades, with stress-related mental disorders now accounting for around 20% of all ongoing cases. A similar trend is ...

Identification of asthma phenotypes has become pivotal to providing better disease management, as it enables the implementation of precision medicine-based approaches. Biomarkers are essential in connecting asthma ...