The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options. Deregulated Rho-GTPases, a family of hydrolase ...

Obesity is associated with a low-grade chronic inflammation with increased levels of proinflammatory markers in the circulation and local inflammation in the adipose tissue. In this thesis, two aspects of obesity-related ...

Background: Sudden Cardiac Arrest (SCA) is a highly lethal medical emergency, caused by an abrupt cessation of cardiac function. Despite extensive research efforts, increased public awareness and systematic healthcare ...

A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible ...

Precision medicine holds significant promise for improving the management of type 2 diabetes, yet its implementation faces several challenges. This thesis aims to address existing gaps in precision medicine for type 2 ...

The mechanisms underlying the pathogenesis of chronic obstructive pulmonary disease (COPD), asthma and COVID-19 are not completely understood. The small airways, which are lined with the respiratory tract lining fluid ...

The prevention of infections in patients with hematological malignancies is important given the inherent immune deficiency associated with these diseases and the immunosuppressive effects of treatment. This thesis investigated ...

Cardiac arrest (CA) refers to the cessation of cardiac function. Survival is around 30% for in-hospital cardiac arrest (IHCA), and 10% for out-of-hospital cardiac arrest (OHCA). Many factors influence survival, ranging ...

Background: In predisposed individuals with a known or unknown cardiovascular disease, the risk of a sudden cardiac arrest is increased during and immediately after exercise. The most common postmortem diagnosis of ...

B cells play an integral part of our immune system. In adults they develop in the bone marrow in a regulated process in which the specificity of their B-cell antigen receptor (BCR), a membrane bound antibody, is established. ...