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Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes
(2022-02-08)
ABSTRACT
Aims
The overall aim of this doctoral thesis was to further examine the anthropometric, metabolic and adipose tissue dysfunctions, as well as explore novel metabolites, associated with type 2 diabetes mellitus ...
Unmet need for mental healthcare among men Sweden: Gendered pathways to care
(2022-02-02)
Aim: Depression and anxiety disorders have a lifetime prevalence of about 10% among men in high-income countries but many do not seek and receive the care that they need. The aim of this thesis was to explore gendered ...
Occupational heat exposure and kidney disease - Studies on the role of heat stress in the Mesoamerican epidemic of Chronic Kidney Disease of non-traditional origin
(2022-05-19)
This thesis examines the association between heat stress and kidney disease in Mesoamerica using different perspectives and methods. An ecologic study found that hot, sugarcane-cultivating regions had elevated chronic ...
Physical activity and exercise in patients with intermittent claudication
(2022-09-26)
Introduction. Supervised exercise is a guideline recommendation in patients with intermittent claudication (IC). As the availability of supervised exercise varies, interest has turned to the more accessible home-based ...
Female sex hormones and health outcomes in women with specific focus on asthma
(2022-11-25)
In humans, gender differences exist across a wide spectrum of diseases. For instance, women are more likely to develop Sjogren’s syndrome, systemic lupus erythematosus, and autoimmune thyroid disease compared to men. On ...
The role of galectin-1 in type 2 diabetes. Clinical and experimental studies
(2022-05-27)
Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes.
Study I: Through a combination of microdialysis and ...
Cause-Specific Mortality and Physical Fitness in Mental Disorders - Epidemiological and Internventional Studies
(2022-04-28)
Mental illnesses are common and constitute a substantial health-related and financial burden on both the individual and society. Mental disorders in general have increased risk of somatic morbidity. An early age of onset ...
Hypertension, atherosclerosis and fracture risk - observational investigations with focus on antihypertensive therapy
(2022-04-28)
Aim: To investigate associations between hypertension, arteriosclerotic disease, and fracture risk in adults and the elderly, with a certain focus on how specific antihypertensive drug treatments in patients with high blood ...
Cardiopulmonary bypass: Clinical studies in cardiac surgery patients
(2022-11-01)
BACKGROUND: Cardiopulmonary bypass (CPB) is necessary to facilitate most cardiac operations. Although the vast majority of patients tolerate CPB physiology in conjunction with cardiac surgery well, there is risks of adverse ...
Thymic exosomes - effects on selection and maturation of thymocytes
(2022-04-22)
T cell tolerance is primarily shaped in the thymus, through direct and indirect presentation of self-antigens to developing T cells. Medullary thymic epithelial cells (mTECs), producing and expressing self-antigens, together ...