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Diabetes and obesity in primary health care - a condition beyond physiological factors
(2011-11-18)
Aims: The objectives of this thesis are to illustrate how obese and normal-weight individuals with type 2 diabetes (T2DM) experience their health status and health care interactions and to highlight the diabetes team ...
Adipose tissue-derived serum amyloid A and adipose tissue macrophages in metabolic disease
(2013-11-29)
Obesity is associated with a low-grade chronic inflammation with increased levels of proinflammatory markers in the circulation and local inflammation in the adipose tissue. In this thesis, two aspects of obesity-related ...
Barriers and Facilitators of Health Promotion and Obesity Prevention in Early Childhood: A Focus on Parents Results from the IDEFICS Study
(2014-02-10)
Background: Childhood obesity has increased dramatically during the past thirty years. Parents are key persons in their children’s lives and their efforts to create healthy lifestyles are very important. However, social ...
Effects of gastric bypass surgery in patients with obesity and type 2 diabetes
(2019-05-17)
Background: The effects of Roux-en-Y gastric bypass (GBP) have not been adequately explored in patients with concurrent obesity and type 2 diabetes mellitus (T2DM) to the same extent as has occurred for individuals with ...
Carbonic anhydrase activity in sleep apnea - a potential therapeutic mechanism for intervention
(2016-11-30)
There is no pharmacological treatment for obstructive sleep apnea (OSA) in clinical practice. The overall aim of this thesis was to investigate the effect of carbonic anhydrase (CA) enzyme activity on sleep apnea severity ...
Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies
(2015-03-03)
Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on ...
Weight loss studies in obese patients. Aspects of very-low-energy diet treatment and effects of obesity surgery on disability pension
(2010-03-02)
Obesity is associated with increased risk of serious medical conditions, impaired quality of life, reduced working capacity, and shortened life expectancy. Obesity surgery is the most effective weight loss treatment with ...
Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)
The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and
action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also
investigated ...
Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome
(2016-05-31)
Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system
and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against ...
Surveillance of childhood obesity in Sweden. Focus on lifestyles and socioeconomic conditions.
(2014-09-05)
Background and aim: There is a general lack of childhood obesity surveillance systems throughout Europe, including Sweden. Such systems are needed to develop policies, evaluate interventions and track secular changes in ...