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Cardiovascular risk factors in renal artery stenosis
(2017-05-11)
Renovascular hypertension (RVH) caused by atherosclerotic renal artery stenosis (ARAS) is
one of the most common forms of secondary hypertension. The prognosis for patients with
RVH is much worse compared to patients ...
Antimicrobial peptides in the treatment of infectious and inflammatory conditions - Preclinical studies of mechanism of action, efficacy, and safety
(2016-10-20)
The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious ...
Iron deficiency in female adolescent athletes - prevalence, mechanisms and diagnostics
(2014-05-26)
Background: Iron deficiency (ID) is a very common condition and the most
common nutritional deficiency in the world. ID mostly affects females, both
athletes and non-athletes. Several underlying mechanisms are identified ...
Resistin is a modulator of inflammation and autoimmunity
(2009-11-18)
Resistin is a protein with proinflammatory properties in man and a regulator of glucose
metabolism in mice. Human resistin activates the nuclear factor kappa-B dependent
cytokine cascade; however, its full role in ...
Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)
The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and
action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also
investigated ...
Cardiovascular structure and function in obesity. The impact of body composition, sleep apnea and sustained weight loss
(2012-10-23)
Background: Obesity is associated with disturbances in cardiovascular structure and function varying along with the degree of fatness, but the mechanisms underlying this co-variation are unclear. Short-term weight loss ...
Studies on the atherogenicity of apoB-containing lipoproteins in type 2 diabetes
(2009-01-15)
Type 2 diabetes (T2D) and the metabolic syndrome (MetS), two conditions that are rapidly increasing in prevalence, as well as the dyslipoproteinemia and subclinical inflammation characteristic for these conditions, are ...
The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis
(2011-10-28)
S100A4 belongs to the family of calcium-binding S100 proteins and modulates cell proliferation,
cytoskeletal rearrangement, cell motility, and angiogenesis. Increased levels of S100A4 expression
correlate with high ...
Vascular and metabolic effects of selective PDE-5 inhibition - clinical and experimental studies
(2015-02-13)
ABSTRACT
Vascular and metabolic effects of selective PDE-5 inhibition
Clinical and experimental studies
Lovisa Sjögren
Department of Molecular and Clinical Medicine, Institute of Medicine at Sahlgrenska Academy, ...
Immunomodulation by estrogen and estren
(2007-03-02)
Estrogen affects the development and regulation of the immune system. Treatment of gonadectomized mice with estrogen results in suppression of T and B lymphopoiesis, as well as decreased delayed type hypersensitivity ...