Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Subject "obesity"
Now showing items 1-20 of 20
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Adipose tissue-derived serum amyloid A and adipose tissue macrophages in metabolic disease
(2013-11-29)Obesity is associated with a low-grade chronic inflammation with increased levels of proinflammatory markers in the circulation and local inflammation in the adipose tissue. In this thesis, two aspects of obesity-related ... -
Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome
(2016-05-31)Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against ... -
Barriers and Facilitators of Health Promotion and Obesity Prevention in Early Childhood: A Focus on Parents Results from the IDEFICS Study
(2014-02-10)Background: Childhood obesity has increased dramatically during the past thirty years. Parents are key persons in their children’s lives and their efforts to create healthy lifestyles are very important. However, social ... -
Body weight, body size and early cardiovascular disease. Epidemiological studies using Swedish registries
(2021-05-04)Background: Obesity is a known risk factor for cardiovascular morbidity and mortality, as well as for atrial fibrillation and heart failure. While overweight and obesity have become increasingly more common in Sweden and ... -
Carbonic anhydrase activity in sleep apnea - a potential therapeutic mechanism for intervention
(2016-11-30)There is no pharmacological treatment for obstructive sleep apnea (OSA) in clinical practice. The overall aim of this thesis was to investigate the effect of carbonic anhydrase (CA) enzyme activity on sleep apnea severity ... -
Cardiovascular and metabolic control in obese children and adolescents
(2008-05-23)Childhood obesity is an emerging risk factor for disease and mortality worldwide. The cardiovascular consequences and prevention thereof need to be further investigated. Exercise and weight loss are well examined and ... -
Childhood overweight and obesity in preschool children - an emerging problem in urban and rural Vietnam. A study of epidemiology and associated factors.
(2017-03-10)Background: Childhood overweight and obesity is considered a global epidemic. From being a health problem mainly in high-income countries, it is now an emerging problem in low- and middle-income parts of the world as well. ... -
Diabetes and obesity in primary health care - a condition beyond physiological factors
(2011-11-18)Aims: The objectives of this thesis are to illustrate how obese and normal-weight individuals with type 2 diabetes (T2DM) experience their health status and health care interactions and to highlight the diabetes team ... -
Effects of gastric bypass surgery in patients with obesity and type 2 diabetes
(2019-05-17)Background: The effects of Roux-en-Y gastric bypass (GBP) have not been adequately explored in patients with concurrent obesity and type 2 diabetes mellitus (T2DM) to the same extent as has occurred for individuals with ... -
Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies
(2015-03-03)Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on ... -
Heart Failure and Aortic Stenosis - Factors Influencing Prognosis and Development
(2021-04-27)Background: An ageing population increases the prevalence of heart failure (HF) and aortic stenosis (AS). Several studies have investigated prognosis and predictors of HF with preserved ejection fraction (HFpEF) compared ... -
Identification and imaging of lipids in tissues using TOF-SIMS
(2008-08-19)Introduction: Normal lipid metabolism in the adipose tissue, skeletal muscle and aortic wall is important for the physiological function of these tissues. Dyslipidemia that is often associated with intake of high energy ... -
The interplay between bile acids and gut microbiota in metabolic and hepatobiliary disease
(2023-11-21)The gut microbiota, a metabolic regulator, orchestrates the production of bioactive metabolites such as secondary bile acids. Growing evidence suggests that shifts in the gut microbiota composition are linked to metabolic ... -
Microarray analysis of gene expression in human adipocytes and adipose tissue
(2008-02-21)Obesity has reached epidemic proportions worldwide and is associated with several serious conditions such as insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Adipose tissue exerts important endocrine ... -
Molecular mechanisms in obesity-associated metabolic disease
(2007-07-12)Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. This thesis ... -
Obesity, Weight Loss and Cardiovascular Risk
(2020-05-26)Background: The global prevalence of obesity is on the rise, contributing to increased incidence and prevalence of cardiovascular morbidity and mortality. Obesity has adverse effects on cardiac structure and function, ... -
Psoriatic arthritis: cardiovascular risk factors, health-related quality of life and effects of weight loss treatment
(2023-03-15)Background: Psoriatic arthritis (PsA) is an inflammatory rheumatic disease, characterized by arthritis, dactylitis, enthesitis and sometimes axial disease. PsA is associated with several comorbidities and reduced health-related ... -
Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also investigated ... -
Surveillance of childhood obesity in Sweden. Focus on lifestyles and socioeconomic conditions.
(2014-09-05)Background and aim: There is a general lack of childhood obesity surveillance systems throughout Europe, including Sweden. Such systems are needed to develop policies, evaluate interventions and track secular changes in ... -
Weight loss studies in obese patients. Aspects of very-low-energy diet treatment and effects of obesity surgery on disability pension
(2010-03-02)Obesity is associated with increased risk of serious medical conditions, impaired quality of life, reduced working capacity, and shortened life expectancy. Obesity surgery is the most effective weight loss treatment with ...