Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Issue Date
Now showing items 41-60 of 605
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Hip fracture prevention by screening and intervention of elderly women in Primary Health Care
(2007-09-18)Hip fracture prevention by screening and intervention of elderly women in Primary Health Care Daniel Albertsson Background – One in four Swedish women suffers a hip fracture (HF). In order to identify high-risk women we ... -
Dilemmas and consequences of chronic disease-lived experiences of coeliac disease and neuropathic pain
(2007-09-27)Dilemmas and consequences of chronic disease-lived experiences of coeliac disease and neuropathic pain Akademisk avhandling som för avläggande av medicine doktorsexamen vid Sahlgrenska akademin vid Göteborgs Universitet ... -
Myocardial creatine metabolism in experimental infarction and heart failure
(2007-10-04)The failing heart is characterized by changes in structure, function and metabolism. All these changes are usually defined as pathologic remodelling. An important part of this negative remodelling process is disturbances ... -
Diagnosis of interatrial shunts and the influence of patent foramen ovale on oxygen desaturation in obstructive sleep apnea
(2007-11-06)Patent foramen ovale (PFO) is found in 27% of the population and although mostly asymptomatic, PFO has been associated with e.g. cryptogenic stroke and, rarely, also with oxygen desaturation. PFO and atrial septal defects ... -
Effects of Biomechanical Stress on Gene Regulation in Vascular Cells
(2007-11-16)The vascular vessel wall is constantly exposed to biomechanical forces, such as shear and tensile stress. Biomechanical forces are important for several physiological and pathological processes and have been shown to ... -
How can we optimize bystander basic life support in cardiac arrest?
(2007-11-23)The aim of this thesis was to describe various aspects of cardiopulmonary resuscitation (CPR) and CPR training in order to find approaches for enhancing bystander interventions. Cardiac care patients (n=401) were interviewed ... -
Pathophysiological role and clinical relevance of cytokines in hypertensive heart failure. A combined clinical and experimental study
(2007-12-06)Although mortality due to heart failure has decreased significantly in the last decade since the introduction of ACE-inhibitors and β-adrenergic receptor blockers in the management of heart failure, chronic heart failure ... -
Vascular Wall Responses to Bypass Grafting - Studies in Mice
(2008-01-18)Abstract Vein grafts are frequently used in bypass surgery for treatment of coronary artery disease and lower limb ischemia. Unfortunately the long-term patency is impaired by vein graft stenoses due to intimal hyperplasia ... -
Ultrasound evaluation of atherosclerosis and other cardiovascular sources of cerebral embolism
(2008-01-18)The search for embolic sources has high priority in patients presenting with suspected cerebral embolism. Non-invasive cardiovascular ultrasound is frequently used to reveal the presence of carotid stenosis and cardiac ... -
Plasminogen Activator Inhibitor 1 in Platelets - Studies of Synthesis, Activity, and Glycosylation Patterns
(2008-01-24)Plasminogen activator inhibitor 1 (PAI-1) is the main physiological inhibitor of tissue-type plasminogen activator. Thus PAI-1 plays an important role in decreasing the fibrinolytic activity in human blood. PAI-1 is present ... -
Estrogen and raloxifene in experimental arthritis and osteoporosis
(2008-02-14)ABSTRACT In postmenopausal rheumatoid arthritis (RA), both the estrogen deficiency and the inflammatory disease contribute to the development of generalized osteoporosis. This leads to an increased risk of fracture, with ... -
Myocardial metabolism in experimental infarction and heart failure
(2008-02-15)Abstract The heart is an organ heavily dependent on exogenous lipids for the oxidative production of adenosine-triphosphate (ATP) and therefore maintenance of normal cellular energy homeostasis. However, high energy ... -
Microarray analysis of gene expression in human adipocytes and adipose tissue
(2008-02-21)Obesity has reached epidemic proportions worldwide and is associated with several serious conditions such as insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Adipose tissue exerts important endocrine ... -
Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects
(2008-03-18)A common cause for referral to gastroenterologists is chronic watery diarrhoea. Approximately 40% of these patients have idiopathic bile acid malabsorption (BAM) – a condition with unknown aetiology. The 75SeHCAT test, ... -
Assembly and Secretion of Atherogenic Lipoproteins
(2008-03-18)The classical dyslipidemia seen in patients with type 2 diabetes is characterized by elevated serum triglycerides (TG), low levels of high-density lipoprotein cholesterol and the appearance of small, dense low-density ... -
Exosomal Shuttle RNA
(2008-04-04)Exosomes are small membrane nanovesicles of endocytic origin that can be released by many different cells to the extracellular environment. Exosomes have been found in a number of body fluids such as blood plasma, breast ... -
THE WINDING ROAD TO WOMANHOOD. Adolescents´ attitudes towards menstruation, womanhood and sexual health - observational and interventional studies
(2008-05-15)Menarche is a unique marker of female maturation representing the transition from childhood to womanhood. When entering adolescence, children face a number of challenges in areas such as the parent-adolescent relationship, ... -
Proliferative and protective effects of the GH/IGF-I axis on cardiomyocytes and neural progenitor cells
(2008-05-15)Cardiovascular disease is the most common cause of mortality in the Western world and the majority of cardiovascular deaths are caused by coronary artery disease or cerebrovascular disease. Growth hormone (GH) is a ... -
The expression and function of CD25 B cells in man and in mice
(2008-05-15)B cells play an important role both in the physiology and pathology of immune responses by production of antibodies, cytokines and by presentation of antigens. It has been shown that human CD25 expressing B cells display ... -
Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis
(2008-05-16)Blood pressure elevation is a major risk factor for cardiovascular events and the risk increases in a dose-dependant manner. It is of importance to identify subjects prone to develop hypertension and adverse cardiovascular ...