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Working technique during computer work Associations with biomechanical and psychological strain, neck and upper extremity musculoskeletal symptoms
(2007-03-30)About 35 % of the working population in Sweden report that computer use accounts for 50% or more of their total working hours. Among this population approximately 40% of the women and 25% of the men experienced symptoms ... -
Cystic fibrosis in adults. Diagnostic, epidemiologic and quality-of-life aspects
(2007-03-30)Background: Cystic fibrosis (CF) is a severe hereditary disease. The type of mutation in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene will determine the degree of CFTR chloride channel malfunction. ... -
Effects of oestrogen on haemodynamic and vascular reactivity - A study in animal models and humans
(2007-04-28)Effects of Oestrogen on Haemodynamic and Vascular Reactivity A study in animal models and humans Lisa Brandin Institute of Medicine, Department of Emergency and Cardiovascular Medicine, Sahlgrenska University Hospital/Östra, ... -
Medical students' learning of the consultation and the patient-doctor relationship
(2007-05-04)Background: In medical education, learning about the consultation and the patient-doctor relationship is nowadays highly recommended. However, research from educational practice from students’ perspective is needed to ... -
Atherosclerosis in 64-year-old women with diabetes mellitus and impaired glucose tolerance
(2007-05-21)Atherosclerosis in 64-year-old women with diabetes mellitus and impaired glucose tolerance The incidence of obesity and type-2 diabetes (t2D) is rising around the world. T2D is accompanied by an increased risk of ... -
Importance of cardiac reserve for evaluation and prediction of cardiac function and morbidity assessed by low-dose dobutamine stress echocardiography
(2007-05-22)This thesis aimed to evaluate the cardiac reserves capacity to be used to predict treatment effects, sub clinical heart disease and to evaluate b1-adrenoceptor (AR) gene polymorphism (Ser49Gly). Studies were performed ... -
Human response to wind turbine noise - perception, annoyance and moderating factors
(2007-05-23)Aims The aims of this thesis were to describe and gain an understanding of how people who live in the vicinity of wind turbines are affected by wind turbine noise, and how individual, situational and visual factors, as ... -
Outcomes in treated hypertensive men - a follow-up during three decades
(2007-05-24)Objectives: To analyse survival, cause specific mortality and cardiovascular morbidity in relation to cardiovascular risk factors, to investigate the prevalence of type 2 diabetes and the cardiovascular risk this constitutes ... -
Participation in everyday life. Very old persons' experiences of daily occupation, occupation of interest and use of assistive devices.
(2007-05-24)The overall aim of the present thesis was to examine, extend and deepen the understanding of very old persons’ experience of participation in everyday life from an occupational perspective. The thesis consists of four ... -
On cellular sources for intimal hyperplasia after vascular interventions
(2007-05-24)Vascular interventions for the treatment of symptomatic atherosclerosis fail in up to 40 % of the cases during the first year. One important reason is the development of a narrowing process known as intimal hyperplasia ... -
The GH-IGF-1 Axis in Postmenopausal Women with Abdominal Obesity
(2007-06-01)Abdominal obesity is associated with blunted growth hormone (GH) secretion. GH treatment in abdominally obese men reduces visceral adipose tissue (VAT) and improves the metabolic profile. The aim of this study was to ... -
Self-perceived Psychological Health and Vascular Changes in Childhood
(2007-06-08)Self-perceived Psychological Health and Vascular Changes in Childhood AKADEMISK AVHANDLING som för avläggande av medicine doktorsexamen vid Sahlgrenska akademin vid Göteborgs universitet kommer att offentligen ... -
Peripheral and central factors in the pathophysiology of irritable bowel syndrome
(2007-06-14)Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by abdominal pain and/or discomfort together with abnormal bowel habits. The pathophysiology is complex and incompletely understood. ... -
Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress - Implications for hypertensive disease
(2007-06-29)The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA). The endothelium synthesizes and stores t-PA and regulated release of the enzyme is an important local ... -
Molecular mechanisms in obesity-associated metabolic disease
(2007-07-12)Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. This thesis ... -
Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate
(2007-08-15)The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule ... -
Health and Rehabilitation in a Psychosocial Context. A Ten Year Persepctive.
(2007-08-20)Abstract This thesis is a retrospective- and prospective study of 372 long-term sick listed individuals with diseases of the locomotor system that underwent vocational rehabilitation conducted by the Social ... -
Growth Hormone in Athletes
(2007-08-24)Doping with growth hormone (GH) is a well-known problem both among elite athletes and among people training at gyms. It is mainly the anabolic and, to some extent, lipolytic effect of GH that is valued by its users. However, ... -
Mechanism of F-actin crosslinking by filamin A and the anti-inflammatory functions of plasma gelsolin in bodily fluids
(2007-09-10)Gelsolin (GSN) and filamin A (FLNa) are two actin-binding proteins discovered in our laboratory over 30 years ago. GSN is a calcium-activated actin severing and barbed end capping protein that is expressed as both intracellular ... -
Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans
(2007-09-10)Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins ...