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Nerve conduction and vibrotactile perception thresholds in female computer workers and hand-arm vibration-exposed male manual workers
(2010-10-22)Upper limb pain and disability are common problems, especially among working populations. The overall aim of this thesis was to investigate peripheral nerve function in the upper limb by nerve conduction test and vibration ... -
Neutrophil Function and Signaling Induced by Ligands for the Formyl Peptide Receptor 2
(2021-02-15)Neutrophil pattern recognition receptors belonging to the G-protein coupled receptor (GPCR) family play a role in the processes of initiation as well as resolution of inflammatory processes. Formyl peptide receptor 2 (FPR2) ... -
Neutrophil function in health and disease - role of intracellular radicals and galectin-3 as regulators of inflammation
(2013-11-14)The focus for this PhD project has been to investigate neutrophil functions in different (inflammatory) settings with specific focus on phagocyte-derived intracellular reactive oxygen species (ROS) as well as neutrophil ... -
New sensitive and specific methods for sex steroid measurements in rodent serum and tissues
(2023-11-23)Accurate measurement of sex steroids (androgens, estrogens, and progesterone) is essential in research and clinical settings for common diseases including osteoporosis, prostate cancer, breast cancer, and cardiovascular ... -
Non-functioning pituitary adenomas and hypopituitarism - studies on morbidity and mortality
(2022-06-15)Background and aims: Hypopituitarism is most commonly caused by benign pituitary tumors, often resulting in insidious symptoms that develop over a long time. Due to either a mass effect exerted by the tumor, or due to the ... -
Non-functioning pituitary tumours - mortality, morbidity and tumour progression
(2014-04-16)Non-functioning pituitary tumours, i.e. non-functioning pituitary adenomas (NFPA) and craniopharyngiomas (CP), are histologically benign brain tumours. They are, however, associated with hypopituitarism, diabetes insipidus ... -
Non-invasive assessement of coronary flow velocity: Clinical and experimental studies
(2016-11-17)BACKGROUND AND OBJECTIVES Coronary flow velocity (CFV) and coronary flow velocity reserve (CFVR) evaluated by transthoracic ultrasound is a promising method to assess ischemic heart disease. CFVR is the ratio between ... -
Nonfatal injuries in a local context - Analysing social structures and perceptions in young people
(2012-05-24)Background: Injuries are a common health problem in children and young people. The uneven distribution over gender and socioeconomic groups is partly explained by factors at both the individual and family levels, but ... -
NOTUM and RSPO3 in Bone - WNT signaling modulators regulating the skeleton
(2023-05-02)Osteoporosis is a skeletal disease affecting millions of people worldwide, often leading to fragility fractures and a decreased quality of life. There is an unmet medical need for new anabolic, bone building, treatments. ... -
Nutritional impact on health in patients with Rheumatoid Arthritis
(2022-05-19)Objective: Rheumatoid Arthritis (RA) is the most common autoimmune rheumatic disease, affecting around 0.5-1% of the population. The aim of this thesis was to study dietary impact on markers of health in patients with ... -
Nutritional metabolomics: The search for dietary exposure variables
(2018-10-19)To establish associations and causation between diet and health, objective and reliable methods are needed to measure dietary exposure. Metabolomics provide an unbiased tool for exploring the modulation of the human ... -
Nya utmaningar, gamla strategier - om distriktsläkares yrkesroll och attityder till samarbete
(2008-11-10)Background: Being confronted by patients with incurable chronic and psychosocially complicated conditions constitutes one of the major challenges for today’s General Practitioners (GP). The traditional biomedical disease ... -
Obesity - surgical treatment and molecular mechanisms
(2015-11-11)Obesity is a condition of high prevalence and is associated with increased morbidity and mortality. Bariatric surgery is an effective treatment of obesity and reduces the risk for morbidity and mortality, but little is ... -
Obesity in diabetes. Cardiovascular outcomes and risk factor trajectories
(2021-03-23)Introduction: The association between body mass index (BMI) and mortality in diabetes is complex and sparsely investigated for cardiovascular (CVD) outcomes. We aimed to investigate these relationships among patients ... -
Obesity, Weight Loss and Cardiovascular Risk
(2020-05-26)Background: The global prevalence of obesity is on the rise, contributing to increased incidence and prevalence of cardiovascular morbidity and mortality. Obesity has adverse effects on cardiac structure and function, ... -
Obstructive Sleep Apnea in Cardiovascular Disease - Mechanisms and Impact of Treatment
(2015-10-29)ABSTRACT Background: Scientific understanding of obstructive sleep apnea (OSA) has increased exponentially during recent decades, suggesting a link between OSA and cardiovascular disease. Few randomized controlled trials ... -
Obstructive sleep apnea in coronary artery disease: Impact of CPAP treatment
(2016-04-05)Obstructive Sleep Apnea in Coronary Artery Disease: Impact of CPAP treatment Helena Glantz Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, ... -
Occupational heat exposure and kidney disease - Studies on the role of heat stress in the Mesoamerican epidemic of Chronic Kidney Disease of non-traditional origin
(2022-05-19)This thesis examines the association between heat stress and kidney disease in Mesoamerica using different perspectives and methods. An ecologic study found that hot, sugarcane-cultivating regions had elevated chronic ... -
On cellular sources for intimal hyperplasia after vascular interventions
(2007-05-24)Vascular interventions for the treatment of symptomatic atherosclerosis fail in up to 40 % of the cases during the first year. One important reason is the development of a narrowing process known as intimal hyperplasia ... -
On kidney dysfunction in advanced liver disease
(2022-11-10)Aims: The overall aim of this thesis was to characterize factors affecting kidney function in advanced liver disease as well as after liver transplantation and to further understand the complex interaction between acute ...