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B cell subpopulations in the pathogenesis of rheumatoid arthritis
(2019-04-04)B cell depleting therapy has proven to be an effective treatment in rheumatoid arthritis (RA), a disease characterized by the presence of autoantibodies against citrullinated proteins (ACPA) and the Fc portion of IgG ... -
Bacteria-host interplay in Staphylococcus aureus infections
(2013-06-05)Staphylococcus aureus infections are a major healthcare challenge and new treatment alternatives are needed. The key to new therapies is understanding the interplay between bacterial virulence factors and host immune ... -
Barriers and Facilitators of Health Promotion and Obesity Prevention in Early Childhood: A Focus on Parents Results from the IDEFICS Study
(2014-02-10)Background: Childhood obesity has increased dramatically during the past thirty years. Parents are key persons in their children’s lives and their efforts to create healthy lifestyles are very important. However, social ... -
BCG vaccination and the tuberculin skin test in a country with low prevalence of tuberculosis. Epidemiological and immunological studies in healthy subjects.
(2008-10-10)The immune response induced by vaccination with Bacille Calmette-Guérin (BCG) is not fully understood, and the interpretation of the tuberculin skin test (TST) is still under debate. This thesis was based on questions ... -
Bedömning i samverkan - en väg till remission vid schizofreni
(2019-11-11)Background: The process from assessment of symptoms and function to various efforts in psychiatric outpa-tient care is still a "black box". Our knowledge of the connection between processes in care and the patient's status ... -
Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects
(2008-03-18)A common cause for referral to gastroenterologists is chronic watery diarrhoea. Approximately 40% of these patients have idiopathic bile acid malabsorption (BAM) – a condition with unknown aetiology. The 75SeHCAT test, ... -
Biological relevance and prognostic significance of radial artery intima-media thickness
(2014-03-14)Cardiovascular disease (CVD) is the major cause of death both in Sweden and globally. Atherosclerotic vascular changes are considered the major underlying pathology leading to clinical manifestations of CVD, e.g. myocardial ... -
Biologics in Staphylococcus aureus arthritis
(2016-04-05)The emergence of new type of drugs known as biologics has led to rapid disease improvements in many autoimmune arthritic patients. Nevertheless, most of these biologics are immunomodulators that may consequently increase ... -
Biomonitoring of Cadmium - Relationship between Cadmium in Kidney, Blood and Urine, Interpretation of Urinary Cadmium, and Implications for Study Design
(2014-04-04)Cadmium is an environmental contaminant which accumulates in the kidney and can potentially affect human health at relatively low concentrations. Biomarkers such as cadmium in urine or blood are normally used to assess ... -
Bleeding tendency and health-related quality of life in carriers of haemophilia
(2016-05-02)Haemophilia A and B are X-linked disorders caused by impaired synthesis of coagulation factors VIII and IX, respectively. Women who carry the haemophilia trait have about 50 % of normal factor levels. Due to skewed ... -
Blood and Bone - Epidemiological studies on the association between blood and bone
(2021-05-07)Introduction: Preclinical and clinical studies have suggested that blood- and bone cells are interconnected. Aims: To study the association between hematological variables, specifically serotonin, erythropoietin (EPO), ... -
Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis
(2008-05-16)Blood pressure elevation is a major risk factor for cardiovascular events and the risk increases in a dose-dependant manner. It is of importance to identify subjects prone to develop hypertension and adverse cardiovascular ... -
Body mass index and mental health in young people - predictors of early heart failure and cardiomyopathy
(2019-11-18)Heart failure among young people is rare, but in contrast to decreasing incidence rates overall, recent studies have found increasing rates among the young over the last decades. Concomitantly, cardiomyopathies, which ... -
Body weight, body size and early cardiovascular disease. Epidemiological studies using Swedish registries
(2021-05-04)Background: Obesity is a known risk factor for cardiovascular morbidity and mortality, as well as for atrial fibrillation and heart failure. While overweight and obesity have become increasingly more common in Sweden and ... -
Bone density, bone geometry and bone development in young men - the importance of pubertal timing and fracture history
(2015-03-30)Background and objective: Peak bone mass, the maximal bone mass attained in young adulthood, is an important factor of the lifetime risk of developing osteoporosis. The aim of this thesis was to study the development of ... -
Bone Morphogenetic Protein 4 regulates white, beige and brown adipose tissue
(2017-05-10)Obesity and its associated complications, including Type 2 diabetes, are increasing at an epidemic rate globally. Adipose tissue exerts different functions and is central in energy homeostasis, and it consists of white, ... -
Brain-Gut Interactions in Irritable Bowel Syndrome (IBS)
(2018-12-04)Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction defined by recurrent and longstanding abdominal pain and disturbed bowel habits. This thesis aims to deepen the knowledge about aberrant visceral ... -
Cadmium, kidney and bone
(2015-11-11)Toxic heavy metals, such as cadmium, mercury and lead, occur in the environment both naturally and as contaminants due to agricultural and industrial activities. The aims of this thesis were to examine the levels of these ... -
Cancer in organ transplant recipients
(2021-08-27)Tens of thousands of transplantations are performed around the world each year. Organ transplant recipients (OTR) are obliged to receive life-long medical treatment with immunosuppressive drugs to ensure graft function. ...