Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 481-500 of 609
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Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also investigated ... -
Regulation of metabolism and inflammation by two protein kinases - AMPK and STK25
(2014-07-02)Type 2 diabetes mellitus (T2DM) is a widespread metabolic disorder that has reached epidemic proportions globally, and is now considered to be one of the main threats to human health. The currently available treatment ... -
Regulation of metabolism and inflammation in liver and skeletal muscle
(2013-02-19)Type 2 diabetes (T2D) is a complex metabolic disorder characterised by hyperinsulinaemia, hyperglycaemia and dyslipidaemia. Obesity is the major risk factor for development of insulin resistance, a main predictor of T2D. ... -
Regulation of vascular endothelial t-PA expression in inflammation: Potential target for pharmacological modulation
(2011-11-03)The endogenous fibrinolytic system is important for preventing occluding thrombosis and subsequent tissue infarction. The main activator of the fibrinolytic system in the vascular compartment is tissue-type plasminogen ... -
Renal function in cardiac surgery - Clinical and experimental studies
(2018-05-14)Background: Impaired renal function (measured as glomerular filtration rate (GFR)) is a well-known problem after heart surgery and heart transplantation (HTx), affecting both short-term and long-term survival. The reason ... -
Renal hemodynamics in renal artery stenosis and angiotensin II-dependent hypertension. Pathophysiological and diagnostic aspects.
(2011-05-26)Patients with renovascular hypertension have a poor renal and cardiovascular prognosis. To improve the care of these patients, we need to increase knowledge about the pathophysiological mechanisms involved. Thus, the aims ... -
Repolarization studies in the long QT syndrome
(2023-10-26)ABSTRACT Background: Sudden cardiac death in the young is predominantly caused by inherited cardiac conditions. Long QT syndrome (LQTS) is one of the most common of these disorders. Since risk stratification relies largely ... -
Resistin is a modulator of inflammation and autoimmunity
(2009-11-18)Resistin is a protein with proinflammatory properties in man and a regulator of glucose metabolism in mice. Human resistin activates the nuclear factor kappa-B dependent cytokine cascade; however, its full role in ... -
Respiratory tract infections in primary care - aspects of diagnosis and treatment
(2023-04-26)Background Primary health care is accountable for most of the antibiotic prescriptions in humans. In Sweden, most of these antibiotics are used for respiratory tract infections, and pharyngotonsillitis (acute sore ... -
Restless legs syndrome among women with chronic widespread pain
(2016-04-25)Aims: The main aim of this thesis was to explore the prevalence, incidence and severity of Restless Legs Syndrome (RLS) in subjects with Chronic Widespread Pain (CWP). In addition, the thesis aimed to analyse the impact ... -
Rho-GTPases in Rheumatoid Arthritis
(2023-05-24)The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options. Deregulated Rho-GTPases, a family of hydrolase ... -
Risk Factors and Predictors of Heart Failure: from Incidence to Prognosis
(2019-10-30)Background: Heart failure (HF) is a major public health problem affecting at least 26 million people worldwide and one of the leading causes of disability and death. Aims: To identify characteristics associated with ... -
Risk factors for fractures - a link between metabolic bone disease and cardiovascular disease
(2011-09-30)Introduction: Fractures and cardiovascular disease (CVD) are a burden to society, as they result in high morbidity and mortality in both men and women. Aim: The aim was to study prospectively modifiable risk factors for ... -
Risk factors of type 2 diabetes and excess risk of stroke in patients with diabetes
(2016-11-17)The incidence of type 2 diabetes is increasing worldwide, mainly because of increasing life expectancy and changes in lifestyle. However, several other factors may also increase the risk of type 2 diabetes and their ... -
A role of CD44 in atherosclerosis? Studies in mice and humans
(2009-01-12)Atherosclerosis is an inflammatory disease that can lead to clinical complications such as myocardial infarction and stroke. Expressed in both vascular and inflammatory cells, adhesion molecule CD44 can be cleaved from the ... -
Role of environmental toxins in chronic experimental arthrithis - in search for anti-inflammatory pathways of ethanol and nicotine
(2010-11-22)Rheumatoid arthritis (RA) is a common systemic autoimmune disorder and a debilitating disease affecting 1% of the world population. The etiology of RA is an unresolved issue. Environmental factors such as alcohol intake ... -
The role of exosomes and microflora in establishing mucosal tolerance and the protection against allergic disease
(2008-12-02)The role of exosomes and microflora in establishing mucosal tolerance and the protection against allergic disease Nina Almqvist, Departement of Rheumatology and Inflammation Research, The Sahlgrenska Academy University ... -
The role of galectin-1 in type 2 diabetes. Clinical and experimental studies
(2022-05-27)Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes. Study I: Through a combination of microdialysis and ... -
Role of GPIbαlpha Clustering and N-linked Carbohydrates in the Clearance of Refrigerated Platelets
(2006-10-06)The thesis focuses on understanding the mechanisms by which: 1) the macrophage alphaM-subunit recognizes betaN-acetylglucosamine (betaGlcNAc) residues on the von Willebrand factor receptor complex ((GPIbalpha,beta/IX)2V ... -
The Role of Gut Dysfunction and Nutritional Factors in Liver Cirrhosis
(2007-03-14)Malnutrition is a common finding in patients with liver cirrhosis. Malnutrition has been shown to be associated with increased morbidity and mortality. Its pathogenesis remains unclear but both poor dietary intake and ...