Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 348-367 of 604
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Mild to moderate depression in the elderly in primary care - detection, patient centeredness and course
(2012-11-02)Aims; To study the prevalence of and describe factors associated with depressive symptoms and to observe the course in a cohort of elderly primary care patients with mild to moderate depression. To compare a structured ... -
Modulation of Receptor Signaling and Functional Selectivity in Neutrophils
(2017-10-17)Neutrophils are important effector cells of the innate immune system and in the regulation of inflammation. Many of their functions, such as chemotactic migration, secretion of granule constituents and activation of the ... -
Modulatory role of IL-17 in airway inflammation
(2010-05-11)IL-17 orchestrates the accumulation of neutrophils to sites of infection and the release of microbicidal substances, and therefore plays a critical role in the innate immune response to infection. IL-17 is also involved ... -
Molecular genetics of patatin-like phospholipase domain-containing 3 and chronic liver disease
(2014-04-30)Chronic liver disease is a major health burden worldwide. Major determinants of this condition are viral infections, alcohol abuse and obesity. Genetic background modulates the effect of damaging agents on the liver. The ... -
Molecular mechanisms behind the liver-induced acceptance of renal grafts in highly sensitized patients
(2009-12-18)Preformed antibodies directed at donor HLA are considered an absolute contraindication for kidney transplantation, because of the high risk of rejection. Thus, patients with high levels of HLA antibodies have little chance ... -
Molecular mechanisms in obesity-associated metabolic disease
(2007-07-12)Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. This thesis ... -
Molecular mechanisms of the kidney in health and disease
(2011-05-27)In 2010, 307 Swedish patients received a new kidney through transplantation, and the first of April 2011, 603 patients were on the kidney transplant waiting list. In Sweden over 8000 patients are presently in active uremic ... -
Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate
(2007-08-15)The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule ... -
Monitoring of coagulation and platelet function in paediatric cardiac surgery
(2013-12-10)Abstract Background: Paediatric cardiac surgery has developed dramatically during the last decades. Today, a wide range of patients is operated on-from premature neonates to grown up children with congenital heart disease. ... -
Mortality and morbidity in patients with Addison's disease
(2015-02-27)Addison's disease (AD) or primary adrenal insufficiency is a rare disease with an estimated prevalence of 100-140 per million inhabitants and deadly unless treated with glucocorticoids (GCs). Very limited information is ... -
Myocardial creatine metabolism in experimental infarction and heart failure
(2007-10-04)The failing heart is characterized by changes in structure, function and metabolism. All these changes are usually defined as pathologic remodelling. An important part of this negative remodelling process is disturbances ... -
Myocardial ischemia and reperfusion injury, clinical and experimental studies
(2010-06-01)Acute myocardial infarction is the consequence of an occluded nutrient coronary artery. Reperfusion reduces infarct size and enhances the rate of survival. But reperfusion may also, in itself, cause reversible injury, ... -
Myocardial metabolism and ischemia assessed by microdialysis. Clinical and experimental studies in cardiac surgery
(2006-11-23)Background: The available methods to study myocardial metabolism and ischemia show considerable limitations when employed during and after cardiac surgery. Microdialysis is a technique for continuous sampling of substances ... -
Myocardial metabolism in experimental infarction and heart failure
(2008-02-15)Abstract The heart is an organ heavily dependent on exogenous lipids for the oxidative production of adenosine-triphosphate (ATP) and therefore maintenance of normal cellular energy homeostasis. However, high energy ... -
Myofibroblasts and polyploid cells in the conjunctival surface after allogeneic hematopoietic stem cell transplantation
(2011-05-09)Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment modality for hematological malignancies, such as leukemia and lymphoma. However, a major complication of the procedure is ... -
Nerve conduction and vibrotactile perception thresholds in female computer workers and hand-arm vibration-exposed male manual workers
(2010-10-22)Upper limb pain and disability are common problems, especially among working populations. The overall aim of this thesis was to investigate peripheral nerve function in the upper limb by nerve conduction test and vibration ... -
Neutrophil Function and Signaling Induced by Ligands for the Formyl Peptide Receptor 2
(2021-02-15)Neutrophil pattern recognition receptors belonging to the G-protein coupled receptor (GPCR) family play a role in the processes of initiation as well as resolution of inflammatory processes. Formyl peptide receptor 2 (FPR2) ... -
Neutrophil function in health and disease - role of intracellular radicals and galectin-3 as regulators of inflammation
(2013-11-14)The focus for this PhD project has been to investigate neutrophil functions in different (inflammatory) settings with specific focus on phagocyte-derived intracellular reactive oxygen species (ROS) as well as neutrophil ... -
New sensitive and specific methods for sex steroid measurements in rodent serum and tissues
(2023-11-23)Accurate measurement of sex steroids (androgens, estrogens, and progesterone) is essential in research and clinical settings for common diseases including osteoporosis, prostate cancer, breast cancer, and cardiovascular ... -
Non-functioning pituitary adenomas and hypopituitarism - studies on morbidity and mortality
(2022-06-15)Background and aims: Hypopituitarism is most commonly caused by benign pituitary tumors, often resulting in insidious symptoms that develop over a long time. Due to either a mass effect exerted by the tumor, or due to the ...