Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 266-285 of 606
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Hutchison-Gilford Progeria Syndrome – A new treatment strategy and the role of prelamin A in oncogenesis
(2014-04-25)Prelamin A, a CaaX-protein is a key structural protein of the inner nuclear lamina, a meshwork lining the inner nuclear envelope. Farnesylated prelamin A is cleaved just upstream of the farnesylcysteine residue to ... -
Hypertension and cardiovascular risk factors in women - a follow-up study forty years after hypertensive pregnancies
(2013-04-03)The aims of the thesis were to investigate the impact of pregnancy blood pressure, a current diagnosis of hypertension and blood pressure levels on neurohumoral, cardiovascular and metabolic status in postmenopausal women ... -
Hypertension, atherosclerosis and fracture risk - observational investigations with focus on antihypertensive therapy
(2022-04-28)Aim: To investigate associations between hypertension, arteriosclerotic disease, and fracture risk in adults and the elderly, with a certain focus on how specific antihypertensive drug treatments in patients with high blood ... -
Hypertension, Atrial Fibrillation and Aldosteronism - A study of interplay, predictors and outcome
(2018-03-12)Background: Atrial fibrillation (AF) is the most common significant arrhythmia, affecting almost 3% of the adult population in Sweden. Although AF is associated with increased risk of lower quality of life, heart failure, ... -
Hypertoniscreening - Tidig upptäckt av högt blodtryck via tandvården
(2022-04-25)Background: Hypertension is the main risk factor for the world’s total disease burden. This is of significance for public health at national level, for healthcare professionals, resource consumption and costs as well as ... -
I själ och hjärta - Psykosociala faktorer och hjärt-kärlhälsa
(2023-04-04)Cardiovascular disease (CVD) is the leading cause of death in Sweden and worldwide. Although the prevalence is declining in the Western world there are signs of rising prevalence among the young. The overall aim of the ... -
ICT use and mental health in young adults. Effects of computer and mobile phone use on stress, sleep disturbances, and symptoms of depression
(2012-03-01)The overall aim of this thesis was to explore possible associations between information and communication technology (ICT) use and mental health symptoms among young adults. By “ICT” in this context is meant mainly computer ... -
Identification and early detection of cancer patients in primary care
(2018-03-21)Aim The aim of this thesis was to investigate how general practitioners (GP) can identify patients in primary care with potential common cancers, at an early stage. It was also to design a risk assessment tool for colorectal ... -
Identification and imaging of lipids in tissues using TOF-SIMS
(2008-08-19)Introduction: Normal lipid metabolism in the adipose tissue, skeletal muscle and aortic wall is important for the physiological function of these tissues. Dyslipidemia that is often associated with intake of high energy ... -
ILC2s and miRNA regulation in allergy and asthma
(2018-04-12)Asthma is a common respiratory disease that is characterized by chronic inflammation of the airways. In most asthmatic subjects, the immune response is driven by pro-inflammatory type 2 cytokines (interleukin (IL)-4, IL-5 ... -
Immune escape in chronic leukemia
(2015-10-02)Reactive oxygen species (ROS) are produced by myeloid cells as a mechanism of defense against infection, but also to resolve inflammation, as ROS can induce cell death in T cells and NK cells. ROS production may also be ... -
Immune regulation by selective estrogen receptor modulators
(2015-04-30)At menopause, the levels of estrogen decline, leading to loss of estrogen-mediated protective effects on bone and an increased risk of osteoporosis. Hormone replacement therapy, containing estrogen, has been used for many ... -
Immune regulation of herpes simplex virus type 2 infection: Special emphasis on the transcription factor T-bet
(2007-01-03)Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa as well as local sensory neurons. It is the most common cause of genital ulcer disease in humans. The infection ... -
Immunological and Genetic Markers Predicting Treatment Outcome in Hepatitits C Virus Infection
(2012-03-20)Hepatitis C is a blood-borne infection caused by the hepatitis C virus (HCV). A chronic infection, which develops in most infected subjects, may lead to liver cirrhosis with ensuing liver dysfunction and liver cancer. The ... -
Immunological and Microbiological perspectives on Irritable Bowel Syndrome.
(2017-11-24)Abstract Irritable bowel syndrome affects ~11% of the population in the Western world and is characterised by altered bowel habits and abdominal pain. The range of additional symptoms between subjects makes groups of ... -
Immunological, vascular and metabolic actions of androgens
(2020-03-10)Men have higher prevalence of cardiovascular disease (CVD) but lower risk of autoimmune disorders than women. The actions of sex steroids may be involved in the sexual dimorphism of these diseases. Although testosterone, ... -
Immunomodulation by estrogen and estren
(2007-03-02)Estrogen affects the development and regulation of the immune system. Treatment of gonadectomized mice with estrogen results in suppression of T and B lymphopoiesis, as well as decreased delayed type hypersensitivity ... -
Impact of chronic total occlusions, arterial access site, and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry.
(2019-05-17)Impact of chronic total occlusions, arterial access site and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry Background Treatment of ischemic ... -
Impact of Risk Factors and Treatment in Coronary Heart Disease
(2008-12-04)Aims: The aim of the present study was to explore how risk factors and medication influence clinical presentation and mortality in coronary heart disease (CHD) and to explain how much of the decrease in CHD mortality in ... -
Impact of the GH-IGF-I axis in adults - pharmacogenetic and genetic association studies
(2013-03-28)Growth hormone (GH) is a polypeptide hormone which is secreted from the anterior pituitary in a pulsatile pattern. GH is best known by its strong effects on longitudinal growth in children, but the importance of GH is ...