Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 235-254 of 606
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Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies
(2015-03-03)Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on ... -
Genital tract CD4+ T cells for vaccination and protection against Chlamydia trachomatis
(2009-10-19)Vaccination strategies for protection against sexually transmitted diseases (STDs) are lacking due to an incomplete understanding of genital tract T cell responses. This thesis dissects the generation of T helper subsets, ... -
The GH-IGF-1 Axis in Postmenopausal Women with Abdominal Obesity
(2007-06-01)Abdominal obesity is associated with blunted growth hormone (GH) secretion. GH treatment in abdominally obese men reduces visceral adipose tissue (VAT) and improves the metabolic profile. The aim of this study was to ... -
GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function
(2009-08-24)Abstract Cardiovascular disease is a major cause of mortality in the Western world. Another important clinical condition is brain damage due to radiation therapy in cancer patients. This has neurological impairments ... -
Glucocorticoid-induced adrenal insufficiency
(2023-11-02)Background: Glucocorticoids (GCs) are effective in treating many diseases and are widely used. However, glucocorticoid treatment can down-regulate the hypothalamic-pituitary-adrenal axis and lead to glucocorticoid-induced ... -
Glucocorticoids - outcome in patients with glucocorticoid deficiency and Cushing's syndrome
(2012-05-15)Glucocorticoids (GCs) are steroid hormones that have a major impact on human metabolism and are essential for life. Chronic GC overexposure, called Cushing’s syndrome, is characterized by central obesity, muscle atrophy, ... -
Glycaemic control: evaluation of HbA1c as a risk factor and the effect of modern insulins in clinical practice
(2009-04-02)One of the ultimate goals of diabetes care is to minimise diabetic complications. When evaluating insulins it is important to understand what extent of improvements in glycaemic control is clinically relevant in preventing ... -
Gout - epidemiological studies on work outcomes, airborne risk factors and treatment patterns
(2022-11-10)The overall aim of the thesis was to describe the contemporary epidemiology and use of urate-lowering therapy (ULT) for gout in the Swedish region of Dalarna, to describe the impact of the disease with regard to sickness ... -
Graft-versus-Host Disease: Eosinophils, Chimerism and Clinical Features in Patients Undergoing Allogeneic Hematopoietic Stem Cell or Multivisceral Transplantation
(2016-05-12)Abstract Graft-versus-host disease (GVHD) is a potentially severe complication that may develop after allogeneic hematopoietic stem cell transplantation (HSCT). It can also occur after transplantation with isolated ... -
Growth Hormone in Athletes
(2007-08-24)Doping with growth hormone (GH) is a well-known problem both among elite athletes and among people training at gyms. It is mainly the anabolic and, to some extent, lipolytic effect of GH that is valued by its users. However, ... -
Gut bacteria, regulatory T cells and allergic sensitization in early childhood
(2014-01-24)The hygiene hypothesis postulates that reduced or altered microbial exposure early in life may lead to impaired immune maturation and, as consequence of this, development of allergic disorders. Thus, we examined if the ... -
Gut microbial regulation of bile acid metabolism and signaling
(2016-01-25)The collection of microbes in our gastrointestinal tract, the gut microbiota, is an environmental factor that has profound impact on host health and disease. Bile acids are endogenous cholesterol-derived molecules that can ... -
Health and Rehabilitation in a Psychosocial Context. A Ten Year Persepctive.
(2007-08-20)Abstract This thesis is a retrospective- and prospective study of 372 long-term sick listed individuals with diseases of the locomotor system that underwent vocational rehabilitation conducted by the Social ... -
Health economic aspects of stroke: stroke prevention and effects on spouses' healthcare consumption and income
(2023-01-23)The overall aim of this thesis was to investigate two health economic aspects of stroke: (i) the clinical and cost-effectiveness of stroke prevention with left atrial appendage occlusion (LAAO) among persons with atrial ... -
Health hazards and cancer in relation to occupational exposures among Swedish seafarers
(2018-11-19)This thesis explores health hazards for seafarers in the Swedish merchant fleet, and occupational risks for lung cancer, mesothelioma and hematologic malignancy (HM). A special focus has been exposure to benzene and biomarker ... -
Health locus of control, depressive symptoms, and insulin resistance. Implications for treatment and prevention in general population and primary care
(2022-04-14)The disease burden of type 2 diabetes and depression is large and challenging for healthcare systems. Preventive interventions require resources and better knowledge concerning early stages in the development of these ... -
Health-Related Quality of Life and Growth Hormone Treatment
(2019-11-18)Introduction Growth Hormone (GH) is used to increase height in Turner Syndrome (TS), the most common sex-chromosome aberration in women. GH is also beneficial for bone mass. However, little is known about how GH treatment ... -
Hearing-related symptoms among women - Occurrence and risk in relation to occupational noise and stressful working conditions
(2018-05-24)A considerable amount of research has been devoted to the risk of noise-induced hearing loss among industry workers – the majority of whom are men. Much less research has been done in female-dominated human service ... -
Heart Failure and Aortic Stenosis - Factors Influencing Prognosis and Development
(2021-04-27)Background: An ageing population increases the prevalence of heart failure (HF) and aortic stenosis (AS). Several studies have investigated prognosis and predictors of HF with preserved ejection fraction (HFpEF) compared ... -
Heart failure and type 1 diabetes
(2018-03-27)Background: Approximately 45,000 individuals live with type 1 diabetes (T1D) in Sweden. Previous studies have shown an increased risk for heart failure in persons with diabetes, but most of the studies have been in the ...