Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 228-247 of 605
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Function of Surface-Associated Protein and DNA on Extracellular Vesicles
(2018-05-09)Extracellular vesicles (EVs), including exosomes, are nano-sized, lipid bilayer enclosed vesicles that are released into the extracellular environment from by almost all cells. EVs contain biomolecules, such as proteins, ... -
Functional dualism of antimicrobial host defence peptides
(2009-01-26)Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the ... -
Functional Modulation of the Pattern Recognition Formyl Peptide Receptors in Neutrophils - Lipopeptides - allosteric modulators of G-protein coupled receptors
(2017-01-20)G-protein-coupled receptors (GPCRs), which are the largest class of cell-surface receptors, are involved in a range of physiologic processes and pathologies, making this a highly interesting group of proteins as targets ... -
Gastric electrical stimulation. Studies in patients with intractable nausea and vomiting
(2010-03-02)The most severe cases of gastroparesis are refractory to drugs. In the 1990s gastric electrical stimulation (GES) was introduced for treatment of nausea and vomiting in patients with diabetic and idiopathic gastroparesis. ... -
Gastrointestinal Symtoms and Fatigue in Patients with Quiescent Ulcerative Colitis
(2016-11-10)Gastrointestinal symptoms compatible with Irritable Bowel Syndrome (IBS) and fatigue are common in patients with quiescent ulcerative colitis (UC). The causes of these symptoms remain to be clarified. The overall aim of ... -
General Beliefs about Medicines among Pharmacy Clients, Healthcare Students and Professionals - Group Differences and Association with Adherence
(2008-05-23)Background: only about 50% of all medicines are used as the prescriber intended. If medicines are prescribed in an adequate way, an optimised adherence can decrease mortality and hospitalisation and improve health-related ... -
Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies
(2015-03-03)Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on ... -
Genital tract CD4+ T cells for vaccination and protection against Chlamydia trachomatis
(2009-10-19)Vaccination strategies for protection against sexually transmitted diseases (STDs) are lacking due to an incomplete understanding of genital tract T cell responses. This thesis dissects the generation of T helper subsets, ... -
The GH-IGF-1 Axis in Postmenopausal Women with Abdominal Obesity
(2007-06-01)Abdominal obesity is associated with blunted growth hormone (GH) secretion. GH treatment in abdominally obese men reduces visceral adipose tissue (VAT) and improves the metabolic profile. The aim of this study was to ... -
GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function
(2009-08-24)Abstract Cardiovascular disease is a major cause of mortality in the Western world. Another important clinical condition is brain damage due to radiation therapy in cancer patients. This has neurological impairments ... -
Glucocorticoid-induced adrenal insufficiency
(2023-11-02)Background: Glucocorticoids (GCs) are effective in treating many diseases and are widely used. However, glucocorticoid treatment can down-regulate the hypothalamic-pituitary-adrenal axis and lead to glucocorticoid-induced ... -
Glucocorticoids - outcome in patients with glucocorticoid deficiency and Cushing's syndrome
(2012-05-15)Glucocorticoids (GCs) are steroid hormones that have a major impact on human metabolism and are essential for life. Chronic GC overexposure, called Cushing’s syndrome, is characterized by central obesity, muscle atrophy, ... -
Glycaemic control: evaluation of HbA1c as a risk factor and the effect of modern insulins in clinical practice
(2009-04-02)One of the ultimate goals of diabetes care is to minimise diabetic complications. When evaluating insulins it is important to understand what extent of improvements in glycaemic control is clinically relevant in preventing ... -
Gout - epidemiological studies on work outcomes, airborne risk factors and treatment patterns
(2022-11-10)The overall aim of the thesis was to describe the contemporary epidemiology and use of urate-lowering therapy (ULT) for gout in the Swedish region of Dalarna, to describe the impact of the disease with regard to sickness ... -
Graft-versus-Host Disease: Eosinophils, Chimerism and Clinical Features in Patients Undergoing Allogeneic Hematopoietic Stem Cell or Multivisceral Transplantation
(2016-05-12)Abstract Graft-versus-host disease (GVHD) is a potentially severe complication that may develop after allogeneic hematopoietic stem cell transplantation (HSCT). It can also occur after transplantation with isolated ... -
Growth Hormone in Athletes
(2007-08-24)Doping with growth hormone (GH) is a well-known problem both among elite athletes and among people training at gyms. It is mainly the anabolic and, to some extent, lipolytic effect of GH that is valued by its users. However, ... -
Gut bacteria, regulatory T cells and allergic sensitization in early childhood
(2014-01-24)The hygiene hypothesis postulates that reduced or altered microbial exposure early in life may lead to impaired immune maturation and, as consequence of this, development of allergic disorders. Thus, we examined if the ... -
Gut microbial regulation of bile acid metabolism and signaling
(2016-01-25)The collection of microbes in our gastrointestinal tract, the gut microbiota, is an environmental factor that has profound impact on host health and disease. Bile acids are endogenous cholesterol-derived molecules that can ... -
Health and Rehabilitation in a Psychosocial Context. A Ten Year Persepctive.
(2007-08-20)Abstract This thesis is a retrospective- and prospective study of 372 long-term sick listed individuals with diseases of the locomotor system that underwent vocational rehabilitation conducted by the Social ... -
Health economic aspects of stroke: stroke prevention and effects on spouses' healthcare consumption and income
(2023-01-23)The overall aim of this thesis was to investigate two health economic aspects of stroke: (i) the clinical and cost-effectiveness of stroke prevention with left atrial appendage occlusion (LAAO) among persons with atrial ...