Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 176-195 of 605
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Endosonography and pretreatment tumor profiling - from sampling, staining, to sequencing
(2018-03-01)Background and aims: Endosonography-guided fine needle aspiration (EUS-FNA) is imperfect in diagnosing solid pancreatic lesions (SPL) and subepithelial lesions (SEL) including gastrointestinal stromal tumors (GIST). In ... -
Endotoxin-induced inflammation in healthy human airways
(2016-04-11)The aim of this thesis was to investigate the innate immune response in healthy human airways in vivo after simulation of a Gram-negative infection. Intrabronchial exposure to the TLR4 agonist endotoxin was used as a ... -
Energy metabolism and angiogenesis in atherosclerosis and cancer
(2019-10-30)Energy metabolism requires supply of glucose and oxygen. In atherosclerotic plaques and cancer tumors, there are local areas with mismatch in demand and supply of oxygen and nutrients. The resulting cellular energy imbalance ... -
Environmental exposure to fine particles in Gothenburg - personal exposure and its variability, indoor and outdoor levels, and effects on biomarkers
(2013-03-25)Urban particulate air pollution has been associated with adverse health effects in epidemiological as well as experimental studies. The overall aim of this thesis was to characterize environmental exposure to fine particles ... -
Eosinophils, their progenitors and T helper cells in allergic airway inflammation
(2011-11-25)Introduction: Asthma is a heterogeneous chronic lung disease associated with pronounced inflammatory changes in the airways. Eosinophilic inflammation is the trait that is best linked to symptoms and treatment responses ... -
Epidemiological aspects of cardiovascular morbidity and mortality among individuals with diabetes: the relative importance of cardiovascular risk factors
(2018-09-21)Background: Long-term trends of cardiovascular complications and death among patients with diabetes have not been studied extensively. In addition, we aimed to examine the effect of multifactorial risk factor control, as ... -
Epidemiological aspects of health and work ability in the Swedish workforce
(2024-03-25)Background: Many working-age individuals suffer from health issues, impacting their work ability and potentially leading to early workforce exit. More understanding of individual and occupational factors influencing work ... -
Epidemiological aspects of musculoskeletal pain in the upper body. Analyzing common and recurrent binary outcomes
(2010-11-08)The overall aim of this thesis is to gain epidemiological knowledge about musculoskeletal pain in the upper body in light physical work, in relation to gender, psychosocial factors, and computer use; and to compare different ... -
Epidemiological Aspects of Renal Impairment in Patients with Type 2 Diabetes
(2016-05-04)Diabetes is a leading cause of renal impairment (RI) and indication of the need for renal replacement therapy in many parts of the world. Albuminuria and RI are the two main forms of diabetic kidney disease. The overall ... -
Epidemiological Aspects on Assessing and Treating Dyslipidemia in Type 1 Diabetes
(2020-01-08)Background: Cardiovascular disease (CVD) is a major cause of shortened longevity in individuals with type 1 diabetes. Dyslipidemia is one of the important modifiable risk factors. Aims: To investigate different aspects ... -
Epidemiological studies in de novo and secondary acute leukemia
(2018-11-23)Abstract Background Acute leukemia (AL) is a rare blood cancer with poor prognosis in adult patients. Socioeconomic factors are known to impact cancer outcomes, but have not been adequately examined among adult AL patients. ... -
Epidemiology of heart failure and feasibility of home care in patients with worsening chronic heart failure
(2009-11-26)Aim: To investigate gender-specific trends in long-term mortality in patients hospitalised for ischaemic and non-ischaemic heart failure (HF) and explore temporal trends in the risk of HF complicating acute myocardial ... -
Epigenetic regulation of gene expression in the vascular endothelium
(2016-05-12)Epigenetic mechanisms, such as DNA methylation and histone modifications, constitute one way for a cell or an organism to respond to changes in the surrounding environment. While histone modifications are recognized to ... -
Epithelial signatures in respiratory disease
(2021-11-25)The epithelium of the human airways protects us against harm and helps maintain immune homeostasis. In respiratory diseases such as asthma and COPD, the functions of the epithelium are altered and can cause or contribute to ... -
Estimation of risk in the field of osteoporosis
(2011-04-15)Introduction: Osteoporosis has been recognised as an established and well-defined disease that affects more than 75 million people in the United States, Europe and Japan. Osteoporosis has been operationally defined by the ... -
Estrogen and 2-methoxyestradiol: regulation of arthritis, inflammation and reactive oxygen species
(2014-04-25)Rheumatoid arthritis (RA) is characterized by severe synovial inflammation, cartilage destruction, and immune-mediated bone loss. Estrogen ameliorates experimental RA, reducing both inflammation and bone loss. The inflamed ... -
Estrogen and raloxifene in experimental arthritis and osteoporosis
(2008-02-14)ABSTRACT In postmenopausal rheumatoid arthritis (RA), both the estrogen deficiency and the inflammatory disease contribute to the development of generalized osteoporosis. This leads to an increased risk of fracture, with ... -
Estrogen receptor α and Bone – Posttranslational modifications and cell-specific deletion
(2019-10-30)Estrogen is involved in the regulation and development of reproductive organs. In addition, estrogen regulates several other organs including the skeleton, immune system, and adipose tissue. Estrogen treatment protects ... -
Estrogens and interleukin-17 in arthritis and associated osteoporosis
(2016-11-15)Rheumatoid arthritis (RA), a disease characterized by persistent joint inflammation and joint destruction, is frequently associated with generalized osteoporosis. A female preponderance (3:1) is present in RA, and ... -
Evaluating benefits and harms of screening - the streetlight effect?
(2018-05-25)The general aim of this thesis was to explore how the benefits and harms of screening for a potentially life-threatening disease can be evaluated. Papers I and II are a Cochrane Systematic Review on screening for malignant ...