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Quality of drug treatment in older people - Focus on hip fracture patients and multi-dose drug dispensing
(2013-01-14)The aim of this thesis was to describe the quality of drug treatment (QDT) regarding fall-risk increasing (FRIDs) and fracture-preventing (FPDs) drugs in older hip fracture patients, to evaluate a method for improving such ... -
Quality of life assessment in patients with lung cancer. Clinical implications
(2013-11-22)Quality of life assessment in patients with lung cancer Clinical implications Mercedes Nicklasson Department of Internal Medicine and Clinical Nutrition/ Respiratory Medicine, Institute of Medicine Sahlgrenska Academy ... -
Quality of life, school performance, treatment adherence and gender differences in asthma.
(2009-10-19)The aims of this thesis were to estimate the effectiveness of a computerized asthma education program designed to suit young people (I), to analyze whether quality of life changed over a five year period and whether young ... -
Quantitative analysis of bone scans in prostate cancer patients
(2013-10-25)Prostate cancer (PCa) is one of the most common diseases in the world. PCa can primarily disseminate to the bone, causing bone metastases, which in turn can lead to death. It is important to diagnose bone metastases as ... -
Quantitative methods for evaluation of tremor and neuromotor function: Application in workers exposed to neurotoxic metals and patients with essential tremor
(2010-09-03)The overall purpose of this thesis was to investigate the usefulness of certain quantitative methods for detecting or quantifying changes in tremor or other neuromotor functions. Tremor and impairment in neuromotor function ... -
Re-interventions after endovascular aortic repair: clinical and experimental studies
(2016-04-25)Background: Endovascular aortic repair (EVAR) has lower morbidity and mortality than open surgery. Late complications and re-interventions are more common, however, and the timing of different re-interventions and their ... -
Receptor Cross-talk and Neutrophil Function
(2013-05-08)The chemotactic recruitment of neutrophils, the most abundant white blood cell in human circulation, to sites of infection and inflammation, is dependent upon a gradient of chemoattractants released from cells at the ... -
Reconstruction of the RVOT with a conduit: Lifetime follow up
(2016-01-15)Background: The use of a conduit is an established surgical method for reconstruction of the right ventricular outflow tract in congenital heart disease. The most commonly used conduit is a homograft. Its limited ... -
Register-based evaluation of primary care - Focus on chronic disease
(2019-09-19)Background: Options for following up primary care at the regional level have increased in Sweden, partly as a result of a national reform in 2009. In Region Västra Götaland (VGR) this was the starting point for a quality ... -
Registry studies on myelodysplastic syndrome and secondary acute myeloid leukemia
(2018-04-18)The aims were (I) to describe a European lower risk MDS population and the use of erythropoietin stimulation agents (ESA), (II) to describe the AML population in Sweden 1997-2006 with emphasis on secondary AML (s-AML) and ... -
Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also investigated ... -
Regulation of metabolism and inflammation by two protein kinases - AMPK and STK25
(2014-07-02)Type 2 diabetes mellitus (T2DM) is a widespread metabolic disorder that has reached epidemic proportions globally, and is now considered to be one of the main threats to human health. The currently available treatment ... -
Regulation of metabolism and inflammation in liver and skeletal muscle
(2013-02-19)Type 2 diabetes (T2D) is a complex metabolic disorder characterised by hyperinsulinaemia, hyperglycaemia and dyslipidaemia. Obesity is the major risk factor for development of insulin resistance, a main predictor of T2D. ... -
Regulation of vascular endothelial t-PA expression in inflammation: Potential target for pharmacological modulation
(2011-11-03)The endogenous fibrinolytic system is important for preventing occluding thrombosis and subsequent tissue infarction. The main activator of the fibrinolytic system in the vascular compartment is tissue-type plasminogen ... -
Renal function in cardiac surgery - Clinical and experimental studies
(2018-05-14)Background: Impaired renal function (measured as glomerular filtration rate (GFR)) is a well-known problem after heart surgery and heart transplantation (HTx), affecting both short-term and long-term survival. The reason ... -
Renal hemodynamics in renal artery stenosis and angiotensin II-dependent hypertension. Pathophysiological and diagnostic aspects.
(2011-05-26)Patients with renovascular hypertension have a poor renal and cardiovascular prognosis. To improve the care of these patients, we need to increase knowledge about the pathophysiological mechanisms involved. Thus, the aims ... -
Repolarization studies in the long QT syndrome
(2023-10-26)ABSTRACT Background: Sudden cardiac death in the young is predominantly caused by inherited cardiac conditions. Long QT syndrome (LQTS) is one of the most common of these disorders. Since risk stratification relies largely ... -
Resistin is a modulator of inflammation and autoimmunity
(2009-11-18)Resistin is a protein with proinflammatory properties in man and a regulator of glucose metabolism in mice. Human resistin activates the nuclear factor kappa-B dependent cytokine cascade; however, its full role in ... -
Respiratory tract infections in primary care - aspects of diagnosis and treatment
(2023-04-26)Background Primary health care is accountable for most of the antibiotic prescriptions in humans. In Sweden, most of these antibiotics are used for respiratory tract infections, and pharyngotonsillitis (acute sore ... -
Restless legs syndrome among women with chronic widespread pain
(2016-04-25)Aims: The main aim of this thesis was to explore the prevalence, incidence and severity of Restless Legs Syndrome (RLS) in subjects with Chronic Widespread Pain (CWP). In addition, the thesis aimed to analyse the impact ...