Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 121-140 of 605
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Decellularization as a method to generate a new generation of vascular grafts
(2020-04-29)Decellularization of blood vessels is a technique to remove cells from the extracellular matrix (ECM), which can be used as a vascular graft for peripheral or coronary blood vessel bypass surgery. This thesis focuses on ... -
Defining orellanine as treatment of advanced renal cell carcinoma
(2014-03-28)Renal cancer causes over 100,000 annual deaths worldwide, and the incidence is increasing. Clear cell renal cell carcinomas (CCRCC), constituting 75% of renal cancer, are known for their high metastatic frequency and ... -
Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer
(2009-04-09)CAAX proteins, such as the RAS and RHO proteins, are recognized by a specific CAAX motif at the carboxyl terminus, which undergoes posttranslational modifications. First, a lipid group is attached to the cysteine (the “C”) ... -
Defining the clinical usefulness of vertebral fracture assessment
(2022-05-10)Objective: Vertebral fractures (VFs) are the most common osteoporotic fracture and among the strongest predictors for future fracture. VFs can be identified by vertebral fracture assessment (VFA) from lateral spine imaging ... -
Defining the importance of protein geranylgeranylation in innate immunity
(2018-11-19)RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed ... -
Defining the Role of GGTase-I in the Development of Rheumatoid Arthritis and Atherosclerosis
(2012-05-08)RHO family proteins control cell movement and intracellular signaling by cycling between active GTP-bound and inactive GDP-bound states. Aberrant signaling of RHO GTPases has been implicated in many diseases including ... -
Determinants of Peak Bone Mass in Men
(2013-01-25)Objective: The aim of this thesis was to identify, investigate and evaluate hereditary and environmental factors associated with peak bone mass or bone development in men. Method: All studies in the thesis were performed ... -
Development and dynamics of the normal gut microbiota
(2020-05-05)Altered gut microbiota configurations have been linked to human diseases. To identify mechanistic links between altered gut microbiota and disease states, definitions of the healthy gut microbiota need to be established. ... -
Development of a New Biomechanical ex vivo Perfusion System - Studies on effects of biomechanical and inflammatory stress on hemostatic genes in human vascular endothelium
(2009-10-06)The vascular endothelium is a multifunctional interface constantly exposed to biomechanical forces such as shear and tensile stress. Biomechanical stress is involved in the pathophysiological process of the vessel wall and ... -
Development of Automated Algorithms for Epicardial Adipose Tissue Analysis in Computed Tomography and their Application in Population Based Research
(2023-12-22)The epicardial adipose tissue (EAT), which surrounds the heart and is separated from other tissues only by the thin layers of the pericardium, has enjoyed intense research for the past decades. Increased inflammatory ... -
Developmental and cholera toxin-induced alterations in the expression of intracellular signalling molecules
(2013-11-27)The innate immune system represents the first line of host defence that reacts promptly to attacks by microbes. This system relies on several families of pathogen-recognition receptors (PRRs), which recognize pathogen-associated ... -
Diabetes and hypertension - entangled chronic conditions in primary care. Time trends and determinants for mortality and cardiovascular complications.
(2021-03-23)Diabetes and hypertension are chronic, often coexisting conditions with increased risk of premature death and cardiovascular complications. This thesis aimed to study different epidemiological aspects regarding risk of ... -
Diabetes and obesity in primary health care - a condition beyond physiological factors
(2011-11-18)Aims: The objectives of this thesis are to illustrate how obese and normal-weight individuals with type 2 diabetes (T2DM) experience their health status and health care interactions and to highlight the diabetes team ... -
Diabetes complications, risk factors, and glycaemic indices in persons with type 1 diabetes
(2023-11-09)Background: Persons with type 1 diabetes are at higher risk of cardiovascular disease and mortality. An important risk factor for diabetes complications is hyperglycaemia. Hyperglycaemia has traditionally been measured ... -
Diagnosis & dietary intervention in patients with diabetic gastroparesis
(2013-09-03)Background: Gastroparesis is a diabetic complication, which is often under-recognised. Existing treatment options are limited and diagnostic methods not easily accessible. Aims of the thesis: To compare two alternative ... -
Diagnosis of interatrial shunts and the influence of patent foramen ovale on oxygen desaturation in obstructive sleep apnea
(2007-11-06)Patent foramen ovale (PFO) is found in 27% of the population and although mostly asymptomatic, PFO has been associated with e.g. cryptogenic stroke and, rarely, also with oxygen desaturation. PFO and atrial septal defects ... -
Diagnosis, mortality and professional life in patients with heart failure
(2023-02-22)Background: Heart failure (HF) is a common and severe disease with an increasing incidence among young adults. An emerging composite endpoint is home-time. Little is known, on how living with HF affects professional life. ... -
Diagnostic aspects of urinary tract infections among elderly residents of nursing homes
(2014-05-05)Background: Up to half the residents of nursing homes for the elderly have asymptomatic bacteriuria (ABU), which should not be treated with antibiotics. Thus, it is difficult to know if new symptoms in residents with ... -
DIAVIP - Diabetes Prevention in Primary Care - Implications for Physical Activity
(2014-03-07)Aim: The overall aim was to study the effect of physical activity in impaired glucose tolerance (IGT) and insulin resistance. We set out to: 1. Evaluate different screening instruments to identify individuals with IGT; ... -
Diet and/or exercise treatment for weight loss in overweight and obese women after childbirth
(2012-11-15)AIM: The aim of the research presented in this thesis was to evaluate whether, dietary behavior modification treatment (D), or physical exercise behavior modification treatment (E), or the combination of both (DE), provide ...