Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Senaste titlar
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Molecular mechanisms of human presynapse assembly - role of liprin-alpha proteins in synapse organization and neurological disease
(2024-04-18)Synapses are the essential transmission units of neuronal circuits and represent the cornerstone of our unique cognitive abilities. During synapse formation, contact between two neurons induce the assembly of pre- and ... -
The Translocation t(7;12)(q36;p13) in Childhood Acute Myeloid Leukemia
(2024-04-11)The reciprocal translocation t(7;12)(q36;p13) gives rise to acute myeloid leukemia (AML) in infants and very young children. A fusion transcript MNX1::ETV6 is sometimes detected and an aberrant expression of MNX1 is ... -
NK cell recognition of malignant cells - a CRISPR approach to define novel mediators
(2024-03-14)Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system, capable of eliminating malignant cells. Their activity is intricately regulated through a balanced interplay between activating and inhibitory ... -
Multiomic profiling of leukemic stem cells in myeloid leukemia: implications for immunotherapy
(2024-02-07)Despite the extensive array of therapies available for treating hematological malignancies, a major challenge in hemato-oncology lies in therapy resistance, which primarily is caused by residual resistant leukemic stem ... -
Understanding the role of the Parkinson’s associated kinase LRRK2 in inflammation and infection
(2024-01-16)The innate immune system, which mediates pathogen clearance and tissue healing, requires tight regulation to avert self-destruction. The endo-lysosomal system is best known as a network of vesicles that targets particles ... -
Immune Cell Profiling of Colorectal Cancers: Unravelling the Connection to Treatment Responses
(2023-11-22)Understanding the interplay between tumor cells and the immune system holds the key to the development of more effective treatments for cancer patients. Therefore, we have emphasized our efforts on deciphering the intricacies ... -
Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis
(2023-11-22)Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune ... -
Neoehrlichiosis - latent infection of endothelium and immune defense
(2023-11-14)This thesis is a study of the tick-borne pathogen Neoehrlichia (N.) mikurensis that causes the infectious disease neoehrlichiosis in humans. The disease affects both individuals with competent and suppressed immune defense ... -
Cellular and molecular mechanisms of kidney injury and regeneration
(2023-11-13)The prevalence of kidney disease is constantly increasing with about 600 million people afflicted globally. Kidney disease may result in end stage renal disease, a condition that requires renal replacement therapy in the ... -
Structural analyses of carbohydrate receptors for enterotoxins and adhesins of enterotoxigenic Escherichia coli
(2023-11-10)Carbohydrate-binding proteins expressed by microbes are key determinants in initiating and sustaining infections that account for millions of deaths each year. This thesis fo- cused on proteins integral to infections ... -
Clostridioides difficile infections: Preventive strategies
(2023-11-02)Clostridioides difficile infections primarily affect elderly, hospitalised patients treated with antibiotics and are among the most common healthcare-related infections. This thesis aimed to improve the understanding of ... -
Infant microbiota and short chain fatty acids - relation to lifestyle and effect on health
(2023-09-21)The commensal microbiota has both beneficial and negative effects on the host. It is a source of infectious and inflammatory microorganisms, but may also provide immune stimulation during a critical period during early ... -
Genomic signatures in viruses
(2023-05-25)In an age of global pandemics, studying how viruses and their genomes evolve is of great importance. It has previously been found that the genomes of many eukaryotes and prokaryotes have specific preferences for nucleotides, ... -
lnclusion body myositis - Genetic, clinical, and epidemiological aspects
(2023-05-16)The inflammatory myopathy inclusion body myositis (IBM) is characterized by progressive muscle weakness and dysphagia in individuals over 45 years of age. Muscle biopsy shows inflammatory infiltrates, vacuoles with protein ... -
Characterization of Epstein-Barr virus non-coding RNAs in infected cells
(2023-05-16)Epstein-Barr virus (EBV) causes multiple types of lymphoid and epithelial malignancies. Unraveling the viral gene expression patterns in tumors and identifying interaction partners between EBV and host elements is crucial ... -
Targeting residual malignant cells in myeloid leukemia
(2023-05-12)Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated ... -
Unconventional T cells in colon adenocarcinomas
(2023-05-05)Many factors influence the initiation and growth of tumours. The infiltration and activity of immune cells in the tumour microenvironment are widely recognised as key factors affecting the clinical outcome of cancer. In ... -
Genomic and transcriptomic profiles in chronic hepatitis B infection
(2023-05-04)Chronic infection with hepatitis B virus (HBV) affects >250 million people globally and is the most common cause of hepatocellular carcinoma and liver cirrhosis worldwide. Approximately one million deaths each year are ... -
Brain tumors in children - National population-based studies on classification, diagnostics and long-term follow-up
(2023-05-02)Although the prognosis for pediatric tumors of the central nervous system (CNS) has improved over time it is urgent to reduce mortality and improve long-term quality of life for survivors. With this aim, the first step is ... -
The functional role of the MUC17-based glycocalyx
(2023-04-27)Our gastrointestinal tract harbors trillions of bacteria that are chemically and spatially separated from the intestinal epithelium. Maintaining an intact mucosal barrier is essential as increased bacterial contact is ...