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Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex
(2008-10-13)
Epstein-Barr Virus (EBV) is an exclusively human, lymphotropic herpes virus
that infects more than 90% of the population worldwide. Primary infection
usually occurs during the early years of life and does not result in ...
The interactome of the Epstein-Barr virus nuclear antigen 5 suggests novel roles in RNA and protein metabolism
(2010-01-19)
Epstein-Barr virus (EBV) is a human herpes virus that infects B and epithelial cells of the oropharynx. EBV is transmitted by saliva and establishes a lifelong latency in over 90% of the world's population. During latency, ...
Regulation of the Epstein-Barr Virus Latent Membrane Protein 1 Expression
(2007-12-21)
Epstein-Barr virus (EBV) is a probably the most effective and successful human virus, infecting more than 90% of the world’s adult population. As with the other members of the herpesvirus family, EBV establishes latent ...
Aspects of infection and leukemia in Rwanda
(2020-05-19)
A first part of this thesis addressed the potential impact of variants of genes encoding interferon-λ4, which is a cytokine that participates in protection against pathogens at epithelial surfaces, for the resolution of ...
Herpesvirus infections in transplant recipients
(2019-10-21)
Abstract
Herpesvirus infections are common and can cause serious and life-threatening conditions in transplanted individuals. In this thesis, consisting of 4 papers (I-IV), we investigated primary infection and reactivation ...
Viral proteins as serological antigens - Development and clinical applications
(2022-05-24)
Serological methods are based on the detection of antibodies and antigens in mainly serum but also in other body fluids such as cerebrospinal fluid (CSF). Conventional whole virus antigens are widely used in viral serological ...
The transcriptomic landscape of Epstein-Barr virus associated tumors at cellular and single-molecule level
(2022-06-10)
Epstein-Barr virus (EBV) was the first oncovirus found in humans. Almost all adults worldwide are asymptomatic carriers of EBV. The latent EBV-infection malignifies in approximately 200,000 individuals each year. The risk ...
Characterization of non-coding mRNA in Epstein-Barr virus
(2007-05-25)
Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects lymphoid and epithelial cells. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disease, and it is additionally ...