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Genome-wide epigenetic profiling of B cell leukemia and lymphoma
(2019-12-06)
Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, ...
Characterizing the role of long non coding RNAs epigenetic regulators in disease model
(2017-11-17)
Long non-coding RNAs (lncRNAs) are a class of biological molecules which are transcribed from DNA but are not translated into any protein. LncRNAs have been identified as critical players in gene regulation. Misregulation ...
On the role of genetic variation and epigenetics in hemostatic gene regulation
(2020-01-17)
Many genetic variants have been identified to associate with circulating levels of hemostatic proteins and with thrombotic or hemorrhagic disorders. However, the underlying molecular mechanisms remain largely unknown. ...
Epigenetics of paediatric glioma stem cells; focusing on exosomes, miRNAs and DNA methylation
(2019-03-14)
Tumours in the central nervous system are accountable for the majority of cancer-related deaths in children. Glioblastoma multiforme, one of the deadliest of the central nervous system tumours, is partly driven by glioma ...
FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects
(2021-11-23)
The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, ...
Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach
(2020-10-07)
One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis ...