Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Subject "IBD"
Now showing items 1-5 of 5
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Commensal microbes, immune reactivity and childhood inflammatory bowel disease
(2009-06-29)Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation of unknown etiology, but immune activation by the commensal microbiota probably plays a major role. The two major categories ... -
Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis
(2011-12-20)The two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders characterized by chronic and relapsing inflammation. Mice deficient in the inhibitory ... -
Intracellular regulation of TLR signaling Basic mechanisms and importance in intestinal inflammation
(2011-04-21)Toll-like receptors (TLRs) recognize conserved structures on/in microorganisms. The intracellular signalling pathways of TLRs are shared with IL-1R and IL-18R and their activation leads to transcription of proinflammato ... -
Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases
(2022-08-23)Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, ... -
The Role of FCGBP in Mucus - Structure, Processing and Function
(2021-10-26)In this thesis, a bottom-up approach was used to study the IgG Fc-binding protein (FCGBP), which next to the MUC2 mucin is the second main component of secreted mucus in small intestine and colon. FCGBP is also found in ...