Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Issue Date
Now showing items 21-40 of 361
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Dynamic changes in T cell compartments and new approaches in evaluating DSS induced and Gai2 deficient colitis
(2007-11-06)The overall aim of this thesis was to increase the understanding of the immunopathology of Inflammatory Bowel Disease (IBD). The first aim was to elucidate how the thymus and the gut epithelium were affected by colitis. ... -
Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy
(2007-11-12)Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack ... -
Evolution of Transmembrane and Gel-forming Mucins Studied with Bioinformatic Methods
(2007-11-13)All mucosal membranes of the body are covered by mucus, largely made up of the family of large glycoproteins called mucins. These are instrumental for the protection of the underlying epithelia and involved in the pathogenesis ... -
Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in Gαi2-deficient and DSS-induced Colitis as well as in IBD patients
(2007-12-06)Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in Gαi2-deficient and DSS-induced Colitis as well as in IBD patients Kristina Elgbratt Department of Microbiology ... -
Functional characterization of the secretory pathway and the role of COPI vesicles
(2007-12-18)In the secretory pathway, proteins synthesized in the endoplasmatic reticulum move through the Golgi apparatus in a cis-to-trans direction and then sorts into different types of vesicles at the trans-Golgi network. How ... -
Regulation of the Epstein-Barr Virus Latent Membrane Protein 1 Expression
(2007-12-21)Epstein-Barr virus (EBV) is a probably the most effective and successful human virus, infecting more than 90% of the world’s adult population. As with the other members of the herpesvirus family, EBV establishes latent ... -
Dendritic cell maturation and death during Salmonella infection. Role of pro-inflammatory cytokines and MyD88
(2007-12-21)The costimulatory molecules CD80 and CD86 are required for the ability of dendritic cells (DC) to induce both tolerance and immunity. This thesis investigates the control of CD80/CD86 upregulation in vivo on DC during ... -
The assembly of cytosolic lipid droplets and its effect on insulin sensitivity
(2007-12-21)Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation ... -
The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes
(2008-02-01)During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate ... -
Genetic Studies of Psoriasis and Psoriatic Arthritis
(2008-02-08)Psoriasis and psoriatic arthritis are common chronic immune-mediated diseases of the skin and joints. Psoriasis affects approximately 2-3 % of the Caucasian population and about 30 % of all psoriasis patients develop ... -
Studies on the Expression and Regulation of Enterotoxins and Colonization Factors in Enterotoxigenic Escherichia coli (ETEC)
(2008-02-28)Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of acute watery diarrhoea in developing countries, particularly among local children less than five years and is also the most common cause of diarrhoea ... -
Regulation and expression of Epstein-Barr virus nuclear antigen 1 in transplant patients and cell culture
(2008-03-27)Epstein-Barr virus (EBV) is a human herpes virus that infects over 90% of the world population. Once infection has occurred, the virus persists for life in its host, mainly in an asymptomatic, latent stage with only a few ... -
Immunofluorescence Investigation on Neuroendocrine Secretory Protein 55 (NESP55) in Nervous Tissues
(2008-03-31)The chromogranin family is a group of acidic, soluble, and heat-stable proteins widespread in various neuronal, neuroendocrine and endocrine tissues, where they are subcellullarly located in the secretory granules, ... -
Directing stem cells and progenitors towards neuronal differentiation - implications for experimental therapies for Parkinson's disease
(2008-04-09)The insight that stem- and progenitor-cells contribute to replacement of nerve cells in the adult central nervous system is the basis of modern therapies for structural brain repair. Their goal is to protect, support and ... -
Hypoxia-inducible factors (HIFs) and biological responses, in hypoxia, inflammation and embryonic vascular development.
(2008-04-21)ABSTRACT Low oxygen tension (hypoxia) is a major inducer of neovascularisation and evidence emerging has indicated that oxygen tension and hypoxia-inducible factors (HIFs), a family of oxygen-regulated heterodimeric ... -
Molecular mechanisms for lineage-restricted differentiation of adult neural progenitors
(2008-05-21)Aims: In the central nervous system of several species, including humans, neurogenesis per¬sists even in the adult life in discrete neurogenic regions of the brain. Adult neural stem cells derived from these neurogenic ... -
Recruitment, Differentiation, and Function of monocytes during Salmonella infection
(2008-05-30)Monocytes are a heterogeneous population in the blood with an enormous plasticity whose fate and functions are dictated by the microenvironment. They are phenotypically and functionally related to neutrophils and dendritic ... -
Autoproteolysis accelerated by conformational strain - a novel biochemical mechanism
(2008-09-08)Natural fragmentation of polypeptide chains by autoproteolysis occurs in a number of protein families. It is a vital step in the maturation of several enzymes and in the formation of membrane-associated mucins that constitute ... -
Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members
(2008-09-29)Aims: The platelet-derived growth factor β-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death. The role ... -
An animal model of sport related concussive brain injury
(2008-10-02)A new animal model for concussion of the type seen in professional football was developed, since current animal models did not simulate these conditions. The model is characterized by a high velocity-low mass impact to the ...