Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 41-60 of 345
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Cellular studies of neuromuscular disorders related to the sarcomeric proteins
(2012-11-21)Sarcomere is the basic unit of cardiac and skeletal muscle contraction and its proper function requires an invariant organization of this structure. Mutations in sarcomeric proteins are known to cause increasing number ... -
Cellular, Molecular and Functional Characterization of the Tumor Suppressor Candidate MYO1C
(2016-03-29)Tumor suppressor genes play a role as a growth regulator and a gatekeeper of a cell. Their inactivation is often detected in malignant tumors. Identification of novel tumor suppressor gene candidates may help to further ... -
Cerebral complications in infective endocarditis
(2009-05-27)Infective endocarditis (IE) is a life-threatening disease. Cerebral embolization complicates the course in 10-40% of IE episodes. Aims of study were to investigate the frequency of cerebrovascular complications (CVC) in ... -
Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in Gαi2-deficient and DSS-induced Colitis as well as in IBD patients
(2007-12-06)Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in Gαi2-deficient and DSS-induced Colitis as well as in IBD patients Kristina Elgbratt Department of Microbiology ... -
Characterization and persistence of potential human pathogenic vibrios in aquatic environments.
(2012-06-18)Vibrio spp., natural inhabitants of aquatic environments, are one of the most common causes of bacterial gastroenteritis in the world, being spread to humans via the ingestion of seafood, contaminated drinking water or ... -
Characterization of Epstein-Barr virus non-coding RNAs in infected cells
(2023-05-16)Epstein-Barr virus (EBV) causes multiple types of lymphoid and epithelial malignancies. Unraveling the viral gene expression patterns in tumors and identifying interaction partners between EBV and host elements is crucial ... -
Characterization of non-coding mRNA in Epstein-Barr virus
(2007-05-25)Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects lymphoid and epithelial cells. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disease, and it is additionally ... -
Characterizing the role of long non coding RNAs epigenetic regulators in disease model
(2017-11-17)Long non-coding RNAs (lncRNAs) are a class of biological molecules which are transcribed from DNA but are not translated into any protein. LncRNAs have been identified as critical players in gene regulation. Misregulation ... -
Chemical basis of ABO subgroups
(2011-10-28)Despite the ABO histo-blood group system being the most biologically significant in humans the chemical structures that define its various phenotypes still remain largely unresolved. Like all blood group systems there ... -
Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach
(2020-10-07)One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis ... -
Citrobacter rodentium and Escherichia coli interactions with mucus producing colonic epithelical cells
(2019-11-06)The epithelial cells together with the mucus layer protect the host from noxious luminal substances and pathogenic invasion. Pathogens have evolved numerous strategies to circumvent these barriers and mount infection. C. ... -
Clinical significance of immunohistochemistry in breast cancer diagnostics
(2023-04-27)For patients with breast cancer, modern patient-tailored treatment depends on tumor- specific characteristics, i.e., estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the ... -
Clostridioides difficile infections: Preventive strategies
(2023-11-02)Clostridioides difficile infections primarily affect elderly, hospitalised patients treated with antibiotics and are among the most common healthcare-related infections. This thesis aimed to improve the understanding of ... -
Colonic mucus structure and processing
(2018-10-05)The mucus layer covering the colonic epithelium creates a crucial first line of defense against the gut residing bacteria. Several lines of evidence suggest that a functional mucus layer is essential for health. For example, ... -
Commensal microbes, immune reactivity and childhood inflammatory bowel disease
(2009-06-29)Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation of unknown etiology, but immune activation by the commensal microbiota probably plays a major role. The two major categories ... -
Community onset sepsis in Sweden - a population based study
(2017-11-17)Sepsis and previously “severe sepsis” are concepts used for denoting organ dysfunction caused by acute infection. Organ dysfunction correlates to increased case fatality rates. Sepsis is a common cause of hospitalization. ... -
Comprehensive analysis of structural genomic alterations in cancer
(2018-02-13)The transformation of a normal cell into a cancer cell involves the accumulation of somatic DNA alterations that confer growth and survival advantages. These genomic alterations can be different in terms of pattern and ... -
Computational analysis of oligosaccharide conformations – methodological development, applied studies, and design of glycomimetics
(2010-05-28)Carbohydrates are the most abundant class of biomolecules. Besides their roles as structural elements and energy storage, they are involved in signaling and recognition processes. Their functions and activities depend on ... -
Computational exploration of cancer genomes
(2019-01-09)Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. ... -
Computational identification of non-coding RNAs
(2007-01-12)A large amount of genomic information is now becoming available. Suitable bioinformatic tools to organize and analyze this vast amount of information are therefore important. In the case of protein genes, the majority of ...