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Application of imaging TOF-SIMS in cell and tissue research
(2007-10-19)This thesis is aimed at extending the use of TOF-SIMS (time of flight secondary ion mass spectrometry) as an analytical tool in cell and tissue research. TOF-SIMS is a relatively new method that allows analysis of the ... -
Approaches to Enhance and Evaluate the Immunogenicity of an Oral ETEC Vaccine
(2015-11-05)Enterotoxigenic Escherichia coli (ETEC) is a major cause of childhood diarrhoea in the developing world and the most common cause of travellers’ diarrhoea. A new oral multivalent ETEC vaccine (MEV) containing killed ... -
Aspects of infection and leukemia in Rwanda
(2020-05-19)A first part of this thesis addressed the potential impact of variants of genes encoding interferon-λ4, which is a cytokine that participates in protection against pathogens at epithelial surfaces, for the resolution of ... -
The assembly of cytosolic lipid droplets and its effect on insulin sensitivity
(2007-12-21)Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation ... -
Autoproteolysis accelerated by conformational strain - a novel biochemical mechanism
(2008-09-08)Natural fragmentation of polypeptide chains by autoproteolysis occurs in a number of protein families. It is a vital step in the maturation of several enzymes and in the formation of membrane-associated mucins that constitute ... -
Bacterial colonization of the neonatal bowel and ileal pouch with focus on E. coli
(2010-11-19)The colonic microbiota is a source of inflammatogenic and potentially pathogenic bacteria, but also a source of immune maturation signals to the infant. Here, we have investigated the normal colonic microbiota, with focus ... -
Biochemical studies of mitochondrial DNA maintenance and topology
(2023-04-14)Mitochondria are crucial organelles in eukaryotic cells that produce the majority of adenosine trisphosphate used by cells as an energy currency to drive metabolic processes. Due to the endosymbiotic origin of mitochondria, ... -
BiolDentification of Alk-associated signaling complexes
(2022-10-25)Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase (RTK) of the insulin receptor family. Alterations in human ALK signaling have been implicated in multiple malignancies including pediatric neuroblastoma. In ... -
Biological functions of G-quadruplexes
(2014-11-24)G-quadruplexes are four-stranded nucleic acid structures formed by quartets of Hoogsteen base paired guanine bases. They are known to form at telomeres and other genomic sites, and are predicted to do so at a large proportion ... -
Biolubrication: Structural investigation of lubricin and its glycosylation
(2014-11-04)The sliding articular cartilage surfaces of the human diarthrodial joints are surrounded by biolubricating synovial fluid (SF), creating a perfect low friction biological biobearing structure with excellent lubrication ... -
Blood Culture Negative Endocarditis
(2006-12-05)The lethal disease infective endocarditis (IE) is caused by microorganisms that attack heart valves. Early diagnosis and identification of the causative agents are important for the choice of treatment. Optimal treatment ... -
Brain tumors in children - National population-based studies on classification, diagnostics and long-term follow-up
(2023-05-02)Although the prognosis for pediatric tumors of the central nervous system (CNS) has improved over time it is urgent to reduce mortality and improve long-term quality of life for survivors. With this aim, the first step is ... -
Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection
(2018-11-12)Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. A vaccine against pandemic ... -
Butyrophilin- and Butyrophilin-like genes and their role in epithelial cell-intraepithelial T lymphocyte cross-talk
(2016-05-04)More than 50% of our immune system is located in the gut. The intestinal epithelium, which forms an interface between the organism and the environment, harbors intraepithelial lymphocytes (IELs) that comprise a mixture of ... -
Candidate antivirals for treatment of respiratory syncytial virus and coronavirus infections: Identification and elucidation of mode of antiviral activity
(2013-09-27)Respiratory syncytial virus (RSV) and coronaviruses (CoVs) are frequent causes of respiratory disease in humans. RSV can cause severe bronchiolitis and pneumonia in infants, especially in those born prematurely or with ... -
Candidatus Neoehrlichia mikurensis - a new agent of tick-borne infectious disease
(2019-09-06)“Candidatus Neoehrlichia mikurensis” (Ca. N. mikurensis) is a tick-borne bacterial pathogen that can cause disease particularly among immune compromised persons. This new infectious disease is called neoehrlichiosis. The ... -
Cartilage Tissue Engineering; the search for chondrogenic progenitor cells and associated signalling pathways
(2009-05-12)The socioeconomic cost of articular cartilage related diseases in the Western world is very high. The suffering of the individual patient is even more problematic. Different methods are used today to treat this large, ... -
Cell cycle regulation in cancer: A noncoding perspective
(2019-11-26)The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. ... -
Cell-based models for studying paediatric high-grade gliomas
(2019-05-06)Brain tumours are the largest group of solid tumours in children and accounts for most cancer-related deaths. Astrocytoma is the largest group, representing almost half of the brain tumours, where high-grade glioma is one ... -
Cellular and molecular mechanisms of kidney injury and regeneration
(2023-11-13)The prevalence of kidney disease is constantly increasing with about 600 million people afflicted globally. Kidney disease may result in end stage renal disease, a condition that requires renal replacement therapy in the ...