Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 292-311 of 345
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Seroepidemiology of vaccine-preventable and emerging RNA viruses in Rwanda
(2018-11-28)Abstract Infectious diseases are a leading cause of death in sub-Saharan Africa, and in Rwanda diarrhea, lower respiratory and other common infections are linked to high mortality and morbidity. For children <5 years of ... -
Small intestinal neuroendocrine tumours - Disease models, tumour development, and remedy
(2019-03-06)Small intestinal neuroendocrine tumours (SINETs) are malignant neoplasms which at the time of diagnosis often present with distant metastasis. The field of SINET research faces several challenges. There is a lack of ... -
Stem cells in the adult heart - 3D culture, isolation of side population cells and search for a stem cell niche
(2017-10-26)Cardiac tissue shows a poor regenerative capacity. From 2003 reports, mostly based on animal models, have showed existence of stem cells also in the heart. Using 14C measurements, a slow but steady turnover of the cardiac ... -
Structural analyses of carbohydrate receptors for enterotoxins and adhesins of enterotoxigenic Escherichia coli
(2023-11-10)Carbohydrate-binding proteins expressed by microbes are key determinants in initiating and sustaining infections that account for millions of deaths each year. This thesis fo- cused on proteins integral to infections ... -
Studies of Carbohydrate-Binding Proteins from Enterotoxigenic Escherichia coli
(2009-04-06)Knowledge about the carbohydrate binding specificity of pathogens can give an increased understanding of their virulence strategies, and is also of importance for the development of anti-adhesive therapies and vaccines. ... -
Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms
(2011-05-27)Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown ... -
Studies on bacterial transmission pathways in a high endemic area, with a focus on Helicobacter pylori
(2009-06-29)Even though half of the world’s population is infected with Helicobacter pylori, which causes gastritis, peptic ulcer and gastric cancer, the transmission routes of these bacteria remain unknown despite extensive epidemiological ... -
Studies on glycosphingolipids in infection, immunity and differentiation
(2015-04-17)Cell surface glycoconjugates play a role in many biological processes such as responses to microbial infections, cell-cell interactions, differentiation, and inflammatory responses. The present work is focused on structural ... -
Studies on interactions of norovirus capsid protein with fucosylated glycans and galactosylceramide as soluble and membrane bound ligands
(2014-05-19)Noroviruses (NVs) are among the most common viral pathogens which target the gastrointestinal (GI) tract and cause severe diarrhea, vomiting and episodes of abdominal cramps with fever. Millions of people around the world ... -
Studies on the Expression and Regulation of Enterotoxins and Colonization Factors in Enterotoxigenic Escherichia coli (ETEC)
(2008-02-28)Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of acute watery diarrhoea in developing countries, particularly among local children less than five years and is also the most common cause of diarrhoea ... -
Studies on therapeutic vaccination and immune evasion in chronic lymphocytic leukemia
(2013-09-10)Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of malignant B cells in blood, bone marrow and secondary lymphoid organs and is considered incurable. Our main aims were to investigate different aspects ... -
A Study of Eosinophils – From the Human Thymus to Eosinophilic Esophagitis
(2022-03-08)Eosinophils are cells of the innate immune system. They primarily reside within tissues and are most numerous in the gastrointestinal tract but are absent from the healthy esophagus. During the inflammatory disease ... -
Study of the colonic mucus layer by mass spectrometry
(2014-12-02)The mucus covering our internal mucosal surfaces is a part of the innate immune system, and the first line of defense against microbial challenges. The need of an efficient defense system is especially important in the ... -
Study the role of patient-specific mutations by genetic disease modeling
(2019-03-01)Many genetic diseases inherited in a dominant fashion have a complex pathological pattern. TOR1A mediated Dystonia-1 (DYT1) is an example of incomplete penetrance, affecting only a third of the carriers. DYT1 is an early-onset ... -
Subsets of intestinal dendritic cells and their role in orally-induced immune responses
(2013-09-20)Vaccination is the most effective means of preventing infectious diseases and improving global health. However, few vaccines have successfully been developed for protection at mucosal surfaces where most infectious pathogens ... -
T cells in colon cancer; migration and effector functions
(2021-12-16)Immune cells are recognised as one of the main players in the tumor microenvironment and targeted by many new cancer therapies. Regulatory T cells (Treg) can suppress tumor infiltrating lymphocytes which are associated ... -
Targeting NOX2 in cancer
(2018-02-27)Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a ... -
Targeting residual malignant cells in myeloid leukemia
(2023-05-12)Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated ... -
Targeting the human glycoproteome: new enrichment protocols and mass spectrometric analyses reveal unique and novel glycosylation sites
(2012-02-10)Glycosylation is one of the most common and structurally diverse posttranslational modifications of proteins. Given that protein glycosylation is involved in various cellular processes, the characterization of site-specific N- ... -
TGF-beta signaling in cancer
(2010-11-19)Transforming Growth Factor beta (TGF-beta) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-beta functions as ...