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Real-time PCR studies of genotypes, mutations and replication of hepatitis B virus
(2012-02-10)Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. Treatment includes interferon and nucleoside analogues (NAs) such as ... -
Recombinant mucin-type proteins as tools for studies on the interactions between Helicobacter pylori and its carbohydrate receptors
(2020-06-11)Glycan-protein interactions are important in pathogen adhesion and infections. H. pylori has adhesins which enables it to bind to glycans on the gastric mucosa and, in the long run, cause gastric cancer. The reported current ... -
Recombinant Mucins with Tailored Glycosylation as Bacterial Toxin Inhibitors
(2015-11-23)Multivalent carbohydrate-based ligands that can inhibit biomedically important protein–carbohydrate interactions have therapeutic potential. One of the important targets for therapeutic intervention is the binding processes ... -
ReCREating BRAF-driven thyroid and lung cancer in mice
(2022-05-17)Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer with a 3:1 female/male incidence. PTC is caused by oncogenic BRAF mutation encoding BRAFV600E in 50% of cases. Prognosis is mostly excellent post- ... -
Recruitment of regulatory and conventional T cells to colon adenocarcinomas
(2013-02-08)Colorectal cancer is one of the most common malignant diseases, with an annual incidence of over one million cases worldwide. Although survival depends strongly on tumor stage at diagnosis, lymphocyte infiltration has been ... -
Recruitment, Differentiation, and Function of monocytes during Salmonella infection
(2008-05-30)Monocytes are a heterogeneous population in the blood with an enormous plasticity whose fate and functions are dictated by the microenvironment. They are phenotypically and functionally related to neutrophils and dendritic ... -
Recurrent infection with Extended-Spectrum Beta-Lactamase (ESBL) -producing Enterobacteriaceae
(2020-05-05)Infections with Extended-Spectrum Beta-Lactamase (ESBL)-producing Enterobacteriaceae (EPE) are increasing globally. The most common EPE are the gut pathogens Escherichia coli (ESBL-E. coli) and Klebsiella pneumoniae (ESBL-K. ... -
Redox reactions in cancer: impact and regulation
(2018-09-28)The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of ... -
Regulation and expression of Epstein-Barr virus nuclear antigen 1 in transplant patients and cell culture
(2008-03-27)Epstein-Barr virus (EBV) is a human herpes virus that infects over 90% of the world population. Once infection has occurred, the virus persists for life in its host, mainly in an asymptomatic, latent stage with only a few ... -
Regulation of gene expression in the vascular wall
(2009-03-31)Blood vessel growth and function are closely related to a number of pathological conditions, including tumor angiogenesis, wound healing and atherosclerosis. Smooth muscle cells (SMC) and endothelial cells (EC), the two ... -
Regulation of gut IgA induction by helper T cells
(2019-11-12)The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. T cell-dependent secretory immunoglobulin ... -
Regulation of Human Mitochondrial DNA Replication and Transcription
(2021-01-18)Regulation of Human Mitochondrial DNA Replication and Transcription Majda Mehmedović Department of Medical Biochemistry and Cell biology, Institute of Biomedicine Sahlgrenska Academy, University of Gothenburg Gothenburg, ... -
Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria
(2009-05-20)Bacteria are classified as Gram-positive or Gram-negative, depending on their cell wall structure. The role of the bacterial cell wall in immune regulation is the focus of the current work. Most Gram-positive bacteria ... -
Regulation of mucosal inflammation by fibroblasts
(2007-04-20)ABSTRACT Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly ... -
Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex
(2008-10-13)Epstein-Barr Virus (EBV) is an exclusively human, lymphotropic herpes virus that infects more than 90% of the population worldwide. Primary infection usually occurs during the early years of life and does not result in ... -
Regulation of the Epstein-Barr Virus Latent Membrane Protein 1 Expression
(2007-12-21)Epstein-Barr virus (EBV) is a probably the most effective and successful human virus, infecting more than 90% of the world’s adult population. As with the other members of the herpesvirus family, EBV establishes latent ... -
Regulatory CD4+FOXP3+ T cells in Helicobacter pylori-induced disease
(2009-10-01)Helicobacter pylori colonize the gastric or duodenal mucosa of approximately half of the worlds’ population. Although most individuals are asymptomatic, H. pylori infection cause peptic ulcers or gastric cancer in 10-15 % ... -
Regulatory T cells and lymphocyte migration into intestinal tumors
(2016-12-13)Tumor-infiltrating lymphocytes (TIL) are crucial for anti-tumor immunity. However, regulatory T cells (Treg) often accumulate in tumor tissue and are able to reduce both lymphocyte activity and transendothelial migration ... -
Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function
(2019-02-27)In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the ... -
Release and Clearance Mechanisms of Cardiac Troponin
(2020-04-28)Myocardial infarction (MI) is often suspected when a patient presents with chest pain. MI is defined as cardiac necrosis due to ischemia, most often mediated through impaired coronary perfusion. Cardiac necrosis results ...