Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 142-161 of 345
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Healing Cartilage - aspects on regenerative methods
(2013-11-27)Articular cartilage has poor intrinsic capacity to heal and defects can cause severe pain for the patient. If the healing process is not assisted the damage might deteriorate and lead to the onset of osteoarthritis. ... -
Helicobacter spp. interactions with mucins: adhesion and mucin regulation of pathogen proliferation and gene expression
(2014-02-10)Helicobacter pylori colonizes the gastric mucosa of approximately half of the world’s population and is a risk factor for gastritis, peptic ulcers and gastric cancer. H. pylori is surrounded by, and adheres to, the heavily ... -
Helicobacter spp. – host interaction in the mucus niche
(2018-11-30)Helicobacter pylori is the most common human gastric pathogen, colonizing half of the world's population. Helicobacter suis colonizes the stomach of 60-95% of pigs at slaughter age and it is the most prevalent non-Helicobacter ... -
Hepatitis B virus replication and integration
(2014-04-11)Chronic infection with hepatitis B virus (HBV) affects 240 million people worldwide and may cause liver disease including hepatocellular carcinoma (HCC). Initially patients have high levels of HBV DNA in their blood, no ... -
Hepatitis B virus RNA in serum and liver tissue - quantification using digital PCR
(2019-12-19)Hepatitis B virus (HBV) infection is a global health issue that is responsible for approximately 900,000 deaths each year, by inducing liver cirrhosis and hepatocellular carcinoma (HCC). A few markers are used to classify ... -
Hepatitis E virus in the virome of water and animals
(2019-11-12)This thesis was aimed to investigate viruses in different animals and water to get some understanding of viruses that disseminate into the environment. Next generation sequencing (NGS) was used to explore the virome from ... -
Hereditary Colorectal Cancer; Identification, Characterization and Classification of Mutations
(2015-01-07)Hereditary factors are thought to play are role in 20-30% of all colorectal cancers Around 6% are found as high penetrant disease-causing mutations in genes correlated to hereditary polyposis or hereditary non-polyposis ... -
Herpes Simplex Virus 1 DNA replication and its role in recombination and transcription
(2015-12-17)Herpes simplex virus 1 (HSV-1) is one of nine different herpesvirus infecting man. They are all capable of establishing a life-long latent state following the primary infection. HSV-1 as well as other herpesviruses may ... -
Herpes simplex virus type 1 infection in the central nervous system - Experimental and clinical studies
(2016-11-17)Alphaherpesvirus infections in the central nervous system (CNS) are rare but severe, and many patients show remaining neurological sequelae. While antiviral treatment has reduced the mortality, morbidity has not been ... -
Herpesvirus infections in transplant recipients
(2019-10-21)Abstract Herpesvirus infections are common and can cause serious and life-threatening conditions in transplanted individuals. In this thesis, consisting of 4 papers (I-IV), we investigated primary infection and reactivation ... -
Herpesvirus-induced glycans: Selectin ligands and related structures on the surface of the infected cell
(2014-01-03)Human herpesviruses are usually acquired early in life and are widely distributed in the population. A common feature of all human herpesviruses is that they persist in the host after the primary infection. Thus, the host ... -
HIV Persistence and Viral Reservoirs
(2010-05-28)Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting ... -
Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus
(2015-10-23)Obesity is a global health problem and affects women of reproductive age. During pregnancy, obesity increases the risk for gestational diabetes mellitus (GDM), in turn predisposing for type 2 diabetes (T2D). Not only the ... -
Human eosinophils and their activation by allergens via danger signal receptors
(2010-03-05)Human eosinophilic granulocytes are polymorphonuclear cells with a powerful arsenal of cytotoxic substances in their granules, which are mainly found in the gastrointestinal mucosa, and the respiratory and genitourinary ... -
Human neutrophil heterogeneity: subsets, markers and autoantibodies
(2016-12-21)ABSTRACT Neutrophils are phagocytic white blood cells that play essential roles in innate im-munity and inflammation. Neutrophils have traditionally been viewed as a homog-enous cell population, where all cells carry the ... -
Humoral and cellular immune response to Helicobacter pylori in Bangladeshi children and adults that may be related to protection
(2010-01-26)Helicobacter pylori (Hp) colonizes the human gastric and duodenal mucosa and the infection may cause peptic ulcers and gastric adenocarcinoma. Half of the world’s population is infected with Hp with the highest prevalence ... -
Hypoxia-inducible factors (HIFs) and biological responses, in hypoxia, inflammation and embryonic vascular development.
(2008-04-21)ABSTRACT Low oxygen tension (hypoxia) is a major inducer of neovascularisation and evidence emerging has indicated that oxygen tension and hypoxia-inducible factors (HIFs), a family of oxygen-regulated heterodimeric ... -
Identification and characterization of progenitor populations in the human adult heart
(2014-01-17)Traditionally, the heart has been regarded as a non-regenerative organ. During the last 10 years, this notion has been challenged. By 14C measurements, it was calculated that at the age of 50, about 45% of all cardiomyocytes ... -
Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements
(2020-05-12)Backgrounds and aims: The evolution of multi-resistant pathogens is seriously threatening our ability to provide modern healthcare. Many of the mobile resistance factors in clinics appear to originate from environmental ... -
Identification of stem cell factors - Novel protein-protein interactions and their functions
(2010-09-10)Embryonic stem (ES) cells provide an unlimited source of cells potentially useful for regenerative medicine, however, prior to clinical implementation, additional basic research is needed. This thesis is focused upon ...