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Candidate antivirals for treatment of respiratory syncytial virus and coronavirus infections: Identification and elucidation of mode of antiviral activity
(2013-09-27)Respiratory syncytial virus (RSV) and coronaviruses (CoVs) are frequent causes of respiratory disease in humans. RSV can cause severe bronchiolitis and pneumonia in infants, especially in those born prematurely or with ... -
Candidatus Neoehrlichia mikurensis - a new agent of tick-borne infectious disease
(2019-09-06)“Candidatus Neoehrlichia mikurensis” (Ca. N. mikurensis) is a tick-borne bacterial pathogen that can cause disease particularly among immune compromised persons. This new infectious disease is called neoehrlichiosis. The ... -
Cartilage Tissue Engineering; the search for chondrogenic progenitor cells and associated signalling pathways
(2009-05-12)The socioeconomic cost of articular cartilage related diseases in the Western world is very high. The suffering of the individual patient is even more problematic. Different methods are used today to treat this large, ... -
Cell cycle regulation in cancer: A noncoding perspective
(2019-11-26)The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. ... -
Cell-based models for studying paediatric high-grade gliomas
(2019-05-06)Brain tumours are the largest group of solid tumours in children and accounts for most cancer-related deaths. Astrocytoma is the largest group, representing almost half of the brain tumours, where high-grade glioma is one ... -
Cellular and molecular mechanisms of kidney injury and regeneration
(2023-11-13)The prevalence of kidney disease is constantly increasing with about 600 million people afflicted globally. Kidney disease may result in end stage renal disease, a condition that requires renal replacement therapy in the ... -
Cellular studies of neuromuscular disorders related to the sarcomeric proteins
(2012-11-21)Sarcomere is the basic unit of cardiac and skeletal muscle contraction and its proper function requires an invariant organization of this structure. Mutations in sarcomeric proteins are known to cause increasing number ... -
Cellular, Molecular and Functional Characterization of the Tumor Suppressor Candidate MYO1C
(2016-03-29)Tumor suppressor genes play a role as a growth regulator and a gatekeeper of a cell. Their inactivation is often detected in malignant tumors. Identification of novel tumor suppressor gene candidates may help to further ... -
Cerebral complications in infective endocarditis
(2009-05-27)Infective endocarditis (IE) is a life-threatening disease. Cerebral embolization complicates the course in 10-40% of IE episodes. Aims of study were to investigate the frequency of cerebrovascular complications (CVC) in ... -
Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in Gαi2-deficient and DSS-induced Colitis as well as in IBD patients
(2007-12-06)Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in Gαi2-deficient and DSS-induced Colitis as well as in IBD patients Kristina Elgbratt Department of Microbiology ... -
Characterization and persistence of potential human pathogenic vibrios in aquatic environments.
(2012-06-18)Vibrio spp., natural inhabitants of aquatic environments, are one of the most common causes of bacterial gastroenteritis in the world, being spread to humans via the ingestion of seafood, contaminated drinking water or ... -
Characterization of Epstein-Barr virus non-coding RNAs in infected cells
(2023-05-16)Epstein-Barr virus (EBV) causes multiple types of lymphoid and epithelial malignancies. Unraveling the viral gene expression patterns in tumors and identifying interaction partners between EBV and host elements is crucial ... -
Characterization of non-coding mRNA in Epstein-Barr virus
(2007-05-25)Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects lymphoid and epithelial cells. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disease, and it is additionally ... -
Characterizing the role of long non coding RNAs epigenetic regulators in disease model
(2017-11-17)Long non-coding RNAs (lncRNAs) are a class of biological molecules which are transcribed from DNA but are not translated into any protein. LncRNAs have been identified as critical players in gene regulation. Misregulation ... -
Chemical basis of ABO subgroups
(2011-10-28)Despite the ABO histo-blood group system being the most biologically significant in humans the chemical structures that define its various phenotypes still remain largely unresolved. Like all blood group systems there ... -
Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach
(2020-10-07)One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis ... -
Citrobacter rodentium and Escherichia coli interactions with mucus producing colonic epithelical cells
(2019-11-06)The epithelial cells together with the mucus layer protect the host from noxious luminal substances and pathogenic invasion. Pathogens have evolved numerous strategies to circumvent these barriers and mount infection. C. ... -
Clinical significance of immunohistochemistry in breast cancer diagnostics
(2023-04-27)For patients with breast cancer, modern patient-tailored treatment depends on tumor- specific characteristics, i.e., estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the ... -
Clostridioides difficile infections: Preventive strategies
(2023-11-02)Clostridioides difficile infections primarily affect elderly, hospitalised patients treated with antibiotics and are among the most common healthcare-related infections. This thesis aimed to improve the understanding of ... -
Colonic mucus structure and processing
(2018-10-05)The mucus layer covering the colonic epithelium creates a crucial first line of defense against the gut residing bacteria. Several lines of evidence suggest that a functional mucus layer is essential for health. For example, ...