Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 72-91 of 347
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Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals
(2013-11-11)The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of ... -
Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes
(2007-08-22)Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are ... -
Development of novel vaccine strains of Vibrio cholerae and studies on the role of serotype in epidemic spread of cholera
(2014-09-26)Cholera, caused by bacterium Vibrio cholerae O1, is a severe diarrheal disease with an estimated 3-5 million cases and more than 140 000 deaths every year particularly affecting children under 5 years of age. It can be ... -
Developmental origin and molecular regulation of vascular smooth muscle cells
(2008-11-18)Several pathologies of the vascular system have been suggested to be dependent on the smooth muscle cells (SMCs) that build up the vessel wall. Aortic SMCs have been proposed to derive from lateral plate mesoderm. It has ... -
Directing stem cells and progenitors towards neuronal differentiation - implications for experimental therapies for Parkinson's disease
(2008-04-09)The insight that stem- and progenitor-cells contribute to replacement of nerve cells in the adult central nervous system is the basis of modern therapies for structural brain repair. Their goal is to protect, support and ... -
DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning
(2008-11-24)131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. For ... -
Dual roles for hepatic lectin receptors in the clearance of chilled platelets
(2009-10-29)Platelets for transfusion are stored at room temperature because refrigerated platelets are cleared rapidly from circulation. Room temperature storage causes major inconveniences for blood banks and medical risks for ... -
Dynamic changes in T cell compartments and new approaches in evaluating DSS induced and Gai2 deficient colitis
(2007-11-06)The overall aim of this thesis was to increase the understanding of the immunopathology of Inflammatory Bowel Disease (IBD). The first aim was to elucidate how the thymus and the gut epithelium were affected by colitis. ... -
Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis
(2018-10-23)Mucus covers our inner interfaces towards the environment, providing protection while enabling vital interaction with the outside world. The mucus is built around mucin proteins, which are important for our defences against ... -
Effects of antioxidant supplementation on cancer progression
(2018-05-18)Popular wisdom holds that antioxidants protect against cancer because they neutralize reactive oxygen species (ROS) and other free radicals which can otherwise cause cancer by damaging DNA. This has been the rationale ... -
Effects of biocides and metals on antibiotic resistance: a genomic and metagenomic perspective
(2017-01-10)Background and aim: There is a concern that biocides and metals can co-select for antibiotic resistance. The aim of this thesis is to enhance our understanding of the roles of antibacterial biocides (e.g. antiseptics, ... -
Embryonic ecdysone-induced gene expression and progression of organ morphogenesis
(2011-05-26)The formation of an epithelial organ requires a set of organ-specific gene programs that instruct parallel and successive developmental events. Still, it is unclear what are the core regulatory programs and how such programs ... -
Embryonic origin and development of thyroid progenitor cells. An experimental study focused on endoderm, EphA4 and Foxa2
(2010-06-04)The thyroid gland consists of two endocrine cell types, the follicular cells that produce the thyroid hormones T3 and T4 and the parafollicular C-cells that synthesize calcitonin. It is well-known that these cells have ... -
Epidemiologic studies on human enteric viruses in Cameroon
(2013-11-27)Enteric viruses are a diverse group of viruses that include those that multiply in the intestinal epithelium and cause gastroenteritis, and those that first multiply in the intestine and then spread to extra-intestinal ... -
Epidemiological and immunological studies of environmental mycobacteria - with focus on Mycobacterium abscessus
(2009-02-27)Mycobacterium avium, M. abscessus and M. gordonae are three mycobacterial species that are ubiquitous in the environment. M. gordonae is non-pathogenic, while M. avium and M. abscessus can cause skin abscesses and airway ... -
Epidemiology of ESBL-producing E. coli with special reference to outbreak detection
(2019-04-30)Multidrug resistant bacteria, particularly extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (EPE), are becoming a major health concern. ESBL-producing Escherichia coli (ESBL-E. coli) is the most prevalent ... -
Epidemiology of viral respiratory infections with focus on in-hospital influenza transmission
(2020-05-18)Human Rhinoviruses (HRV) and influenza viruses are respiratory pathogens which represent a major global disease burden. Healthcare-associated infections (HCAI) are increasingly recognized as a public health concern, but ... -
Epidemiology, molecular characterisation and toxin regulation of enterotoxigenic Escherichia coli (ETEC) isolated from children with diarrhoea
(2013-05-22)Acute diarrhoeal diseases are among the major causes of morbidity and mortality in children under 5 years of age in developing countries. Knowledge of the epidemiology of such diseases and the causative agents is important ... -
Epidemiology, molecular characterization of hepatitis viruses in Rwanda and implication on liver disease
(2018-08-20)Hepatitis viruses cause major health problems worldwide and, according to WHO, is the seventh leading cause of death globally. It is primarily hepatitis B and C virus that causes chronic hepatitis, liver damage and fibrosis, ... -
Epigenetic regulation of oncogenes and tumor suppressors in chronic lymphocytic leukemia
(2017-10-26)DNA methylation is one of the well-known epigenetic modifications. Aberrant DNA methylation has been shown to have a major role in tumorigenesis and is associated with tumor aggressiveness and inferior outcome in various ...