Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 287-306 of 347
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Regulatory T cells and lymphocyte migration into intestinal tumors
(2016-12-13)Tumor-infiltrating lymphocytes (TIL) are crucial for anti-tumor immunity. However, regulatory T cells (Treg) often accumulate in tumor tissue and are able to reduce both lymphocyte activity and transendothelial migration ... -
Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function
(2019-02-27)In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the ... -
Release and Clearance Mechanisms of Cardiac Troponin
(2020-04-28)Myocardial infarction (MI) is often suspected when a patient presents with chest pain. MI is defined as cardiac necrosis due to ischemia, most often mediated through impaired coronary perfusion. Cardiac necrosis results ... -
Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells
(2013-11-29)Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter ... -
Ribonucleotides in DNA - Application in genome-wide DNA polymerase tracking and physiological role in eukaryotes
(2021-05-20)The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the ... -
Rotavirus and polymicrobial enteric infections and their short-term course in East African children
(2017-11-30)Diarrhoeal diseases in children under five years are the second leading cause of deaths in children worldwide, and especially in low-income countries in sub-Saharan Africa and in southern Asia where about 450,000 children ... -
Seroepidemiology of vaccine-preventable and emerging RNA viruses in Rwanda
(2018-11-28)Abstract Infectious diseases are a leading cause of death in sub-Saharan Africa, and in Rwanda diarrhea, lower respiratory and other common infections are linked to high mortality and morbidity. For children <5 years of ... -
Small intestinal neuroendocrine tumours - Disease models, tumour development, and remedy
(2019-03-06)Small intestinal neuroendocrine tumours (SINETs) are malignant neoplasms which at the time of diagnosis often present with distant metastasis. The field of SINET research faces several challenges. There is a lack of ... -
Stem cells in the adult heart - 3D culture, isolation of side population cells and search for a stem cell niche
(2017-10-26)Cardiac tissue shows a poor regenerative capacity. From 2003 reports, mostly based on animal models, have showed existence of stem cells also in the heart. Using 14C measurements, a slow but steady turnover of the cardiac ... -
Structural analyses of carbohydrate receptors for enterotoxins and adhesins of enterotoxigenic Escherichia coli
(2023-11-10)Carbohydrate-binding proteins expressed by microbes are key determinants in initiating and sustaining infections that account for millions of deaths each year. This thesis fo- cused on proteins integral to infections ... -
Studies of Carbohydrate-Binding Proteins from Enterotoxigenic Escherichia coli
(2009-04-06)Knowledge about the carbohydrate binding specificity of pathogens can give an increased understanding of their virulence strategies, and is also of importance for the development of anti-adhesive therapies and vaccines. ... -
Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms
(2011-05-27)Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown ... -
Studies on bacterial transmission pathways in a high endemic area, with a focus on Helicobacter pylori
(2009-06-29)Even though half of the world’s population is infected with Helicobacter pylori, which causes gastritis, peptic ulcer and gastric cancer, the transmission routes of these bacteria remain unknown despite extensive epidemiological ... -
Studies on glycosphingolipids in infection, immunity and differentiation
(2015-04-17)Cell surface glycoconjugates play a role in many biological processes such as responses to microbial infections, cell-cell interactions, differentiation, and inflammatory responses. The present work is focused on structural ... -
Studies on interactions of norovirus capsid protein with fucosylated glycans and galactosylceramide as soluble and membrane bound ligands
(2014-05-19)Noroviruses (NVs) are among the most common viral pathogens which target the gastrointestinal (GI) tract and cause severe diarrhea, vomiting and episodes of abdominal cramps with fever. Millions of people around the world ... -
Studies on the Expression and Regulation of Enterotoxins and Colonization Factors in Enterotoxigenic Escherichia coli (ETEC)
(2008-02-28)Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of acute watery diarrhoea in developing countries, particularly among local children less than five years and is also the most common cause of diarrhoea ... -
Studies on therapeutic vaccination and immune evasion in chronic lymphocytic leukemia
(2013-09-10)Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of malignant B cells in blood, bone marrow and secondary lymphoid organs and is considered incurable. Our main aims were to investigate different aspects ... -
A Study of Eosinophils – From the Human Thymus to Eosinophilic Esophagitis
(2022-03-08)Eosinophils are cells of the innate immune system. They primarily reside within tissues and are most numerous in the gastrointestinal tract but are absent from the healthy esophagus. During the inflammatory disease ... -
Study of the colonic mucus layer by mass spectrometry
(2014-12-02)The mucus covering our internal mucosal surfaces is a part of the innate immune system, and the first line of defense against microbial challenges. The need of an efficient defense system is especially important in the ... -
Study the role of patient-specific mutations by genetic disease modeling
(2019-03-01)Many genetic diseases inherited in a dominant fashion have a complex pathological pattern. TOR1A mediated Dystonia-1 (DYT1) is an example of incomplete penetrance, affecting only a third of the carriers. DYT1 is an early-onset ...