Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 276-295 of 346
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Redox reactions in cancer: impact and regulation
(2018-09-28)The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of ... -
Regulation and expression of Epstein-Barr virus nuclear antigen 1 in transplant patients and cell culture
(2008-03-27)Epstein-Barr virus (EBV) is a human herpes virus that infects over 90% of the world population. Once infection has occurred, the virus persists for life in its host, mainly in an asymptomatic, latent stage with only a few ... -
Regulation of gene expression in the vascular wall
(2009-03-31)Blood vessel growth and function are closely related to a number of pathological conditions, including tumor angiogenesis, wound healing and atherosclerosis. Smooth muscle cells (SMC) and endothelial cells (EC), the two ... -
Regulation of gut IgA induction by helper T cells
(2019-11-12)The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. T cell-dependent secretory immunoglobulin ... -
Regulation of Human Mitochondrial DNA Replication and Transcription
(2021-01-18)Regulation of Human Mitochondrial DNA Replication and Transcription Majda Mehmedović Department of Medical Biochemistry and Cell biology, Institute of Biomedicine Sahlgrenska Academy, University of Gothenburg Gothenburg, ... -
Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria
(2009-05-20)Bacteria are classified as Gram-positive or Gram-negative, depending on their cell wall structure. The role of the bacterial cell wall in immune regulation is the focus of the current work. Most Gram-positive bacteria ... -
Regulation of mucosal inflammation by fibroblasts
(2007-04-20)ABSTRACT Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly ... -
Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex
(2008-10-13)Epstein-Barr Virus (EBV) is an exclusively human, lymphotropic herpes virus that infects more than 90% of the population worldwide. Primary infection usually occurs during the early years of life and does not result in ... -
Regulation of the Epstein-Barr Virus Latent Membrane Protein 1 Expression
(2007-12-21)Epstein-Barr virus (EBV) is a probably the most effective and successful human virus, infecting more than 90% of the world’s adult population. As with the other members of the herpesvirus family, EBV establishes latent ... -
Regulatory CD4+FOXP3+ T cells in Helicobacter pylori-induced disease
(2009-10-01)Helicobacter pylori colonize the gastric or duodenal mucosa of approximately half of the worlds’ population. Although most individuals are asymptomatic, H. pylori infection cause peptic ulcers or gastric cancer in 10-15 % ... -
Regulatory T cells and lymphocyte migration into intestinal tumors
(2016-12-13)Tumor-infiltrating lymphocytes (TIL) are crucial for anti-tumor immunity. However, regulatory T cells (Treg) often accumulate in tumor tissue and are able to reduce both lymphocyte activity and transendothelial migration ... -
Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function
(2019-02-27)In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the ... -
Release and Clearance Mechanisms of Cardiac Troponin
(2020-04-28)Myocardial infarction (MI) is often suspected when a patient presents with chest pain. MI is defined as cardiac necrosis due to ischemia, most often mediated through impaired coronary perfusion. Cardiac necrosis results ... -
Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells
(2013-11-29)Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter ... -
Ribonucleotides in DNA - Application in genome-wide DNA polymerase tracking and physiological role in eukaryotes
(2021-05-20)The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the ... -
Rotavirus and polymicrobial enteric infections and their short-term course in East African children
(2017-11-30)Diarrhoeal diseases in children under five years are the second leading cause of deaths in children worldwide, and especially in low-income countries in sub-Saharan Africa and in southern Asia where about 450,000 children ... -
Seroepidemiology of vaccine-preventable and emerging RNA viruses in Rwanda
(2018-11-28)Abstract Infectious diseases are a leading cause of death in sub-Saharan Africa, and in Rwanda diarrhea, lower respiratory and other common infections are linked to high mortality and morbidity. For children <5 years of ... -
Small intestinal neuroendocrine tumours - Disease models, tumour development, and remedy
(2019-03-06)Small intestinal neuroendocrine tumours (SINETs) are malignant neoplasms which at the time of diagnosis often present with distant metastasis. The field of SINET research faces several challenges. There is a lack of ... -
Stem cells in the adult heart - 3D culture, isolation of side population cells and search for a stem cell niche
(2017-10-26)Cardiac tissue shows a poor regenerative capacity. From 2003 reports, mostly based on animal models, have showed existence of stem cells also in the heart. Using 14C measurements, a slow but steady turnover of the cardiac ... -
Structural analyses of carbohydrate receptors for enterotoxins and adhesins of enterotoxigenic Escherichia coli
(2023-11-10)Carbohydrate-binding proteins expressed by microbes are key determinants in initiating and sustaining infections that account for millions of deaths each year. This thesis fo- cused on proteins integral to infections ...