Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 265-284 of 347
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Presence and viability of enterotoxigenic Escherichia coli (ETEC) in aquatic environments
(2009-12-07)Enterotoxigenic Escherichia coli (ETEC) is one of the major causes of diarrhoea among children in developing countries and in travelers to these regions. The bacteria are spread via contaminated water and food, and surface ... -
Profiling of Small Intestine Neuroendocrine Tumors
(2014-11-04)Small intestine neuroendocrine tumors (SI-NETs) are malignant neoplasms usually presenting with disseminated disease and symptoms of hormone overproduction. Radical surgery is curative but can only be performed for localized ... -
Progesterone's effect on factors that influence gamete transport in the fallopian tube
(2014-11-21)ABSTRACT The fallopian tube plays an important role for successful female reproduction as it transport gametes to the fertilization site, nourish the developing embryo and transport it to the uterus at the suitable time ... -
Prognostic markers in pediatric leukemia and mechanisms of KRAS induced leukemogenesis
(2013-12-20)Leukemia results from uncontrolled growth of genetically altered blood cells. Depending on the cell type of origin, the leukemia is defined as T-cell, B-cell, or myeloid and as acute or chronic depending on its characteristics. ... -
Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins
(2021-11-25)Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging ... -
Real-time PCR studies of genotypes, mutations and replication of hepatitis B virus
(2012-02-10)Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. Treatment includes interferon and nucleoside analogues (NAs) such as ... -
Recombinant mucin-type proteins as tools for studies on the interactions between Helicobacter pylori and its carbohydrate receptors
(2020-06-11)Glycan-protein interactions are important in pathogen adhesion and infections. H. pylori has adhesins which enables it to bind to glycans on the gastric mucosa and, in the long run, cause gastric cancer. The reported current ... -
Recombinant Mucins with Tailored Glycosylation as Bacterial Toxin Inhibitors
(2015-11-23)Multivalent carbohydrate-based ligands that can inhibit biomedically important protein–carbohydrate interactions have therapeutic potential. One of the important targets for therapeutic intervention is the binding processes ... -
ReCREating BRAF-driven thyroid and lung cancer in mice
(2022-05-17)Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer with a 3:1 female/male incidence. PTC is caused by oncogenic BRAF mutation encoding BRAFV600E in 50% of cases. Prognosis is mostly excellent post- ... -
Recruitment of regulatory and conventional T cells to colon adenocarcinomas
(2013-02-08)Colorectal cancer is one of the most common malignant diseases, with an annual incidence of over one million cases worldwide. Although survival depends strongly on tumor stage at diagnosis, lymphocyte infiltration has been ... -
Recruitment, Differentiation, and Function of monocytes during Salmonella infection
(2008-05-30)Monocytes are a heterogeneous population in the blood with an enormous plasticity whose fate and functions are dictated by the microenvironment. They are phenotypically and functionally related to neutrophils and dendritic ... -
Recurrent infection with Extended-Spectrum Beta-Lactamase (ESBL) -producing Enterobacteriaceae
(2020-05-05)Infections with Extended-Spectrum Beta-Lactamase (ESBL)-producing Enterobacteriaceae (EPE) are increasing globally. The most common EPE are the gut pathogens Escherichia coli (ESBL-E. coli) and Klebsiella pneumoniae (ESBL-K. ... -
Redox reactions in cancer: impact and regulation
(2018-09-28)The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of ... -
Regulation and expression of Epstein-Barr virus nuclear antigen 1 in transplant patients and cell culture
(2008-03-27)Epstein-Barr virus (EBV) is a human herpes virus that infects over 90% of the world population. Once infection has occurred, the virus persists for life in its host, mainly in an asymptomatic, latent stage with only a few ... -
Regulation of gene expression in the vascular wall
(2009-03-31)Blood vessel growth and function are closely related to a number of pathological conditions, including tumor angiogenesis, wound healing and atherosclerosis. Smooth muscle cells (SMC) and endothelial cells (EC), the two ... -
Regulation of gut IgA induction by helper T cells
(2019-11-12)The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. T cell-dependent secretory immunoglobulin ... -
Regulation of Human Mitochondrial DNA Replication and Transcription
(2021-01-18)Regulation of Human Mitochondrial DNA Replication and Transcription Majda Mehmedović Department of Medical Biochemistry and Cell biology, Institute of Biomedicine Sahlgrenska Academy, University of Gothenburg Gothenburg, ... -
Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria
(2009-05-20)Bacteria are classified as Gram-positive or Gram-negative, depending on their cell wall structure. The role of the bacterial cell wall in immune regulation is the focus of the current work. Most Gram-positive bacteria ... -
Regulation of mucosal inflammation by fibroblasts
(2007-04-20)ABSTRACT Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly ... -
Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex
(2008-10-13)Epstein-Barr Virus (EBV) is an exclusively human, lymphotropic herpes virus that infects more than 90% of the population worldwide. Primary infection usually occurs during the early years of life and does not result in ...