Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 227-246 of 347
-
Multiomic profiling of leukemic stem cells in myeloid leukemia: implications for immunotherapy
(2024-02-07)Despite the extensive array of therapies available for treating hematological malignancies, a major challenge in hemato-oncology lies in therapy resistance, which primarily is caused by residual resistant leukemic stem ... -
Multiple primary malignancies in breast cancer patients. From population study to genetics
(2021-04-16)Breast cancer (BC) is one of the most common causes of cancer-related death among women worldwide. Due to early detection of BC and more tailor-made treatments, patients live longer despite their illness. Studies have shown ... -
Natural killer T (NKT) lymphocytes regulate of intestinal tumor immunity
(2017-09-01)CD1d-restricted natural killer T (NKT) lymphocytes are known as potent early regulatory cells of immune responses, acting as a bridge between innate and adaptive immunity. While invariant NKT (iNKT) cells have a protective ... -
Neoehrlichiosis - latent infection of endothelium and immune defense
(2023-11-14)This thesis is a study of the tick-borne pathogen Neoehrlichia (N.) mikurensis that causes the infectious disease neoehrlichiosis in humans. The disease affects both individuals with competent and suppressed immune defense ... -
Neural stam cells, TLX, and Neuroblastoma
(2014-09-19)Neuroblastoma (NB) is one of the most commonly diagnosed extracranial tumors in children below five years of age. Moreover, NB accounts for almost 12-15% of all childhood cancer related fatalities. To date, the origin of ... -
The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes
(2009-09-30)Neuroblastoma (NB) is a tumor of the sympathetic nervous system, and the most common extracranial tumor of childhood. The prognosis for high-stage NBs is still poor, with survival rates of about 35%. Side-effects of treatment ... -
New Roles of Filamins in Cell Signaling, Transcription and Organ Development
(2009-03-12)Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell ... -
Next generation molecular diagnostics using ultrasensitive sequencing
(2022-03-15)Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to ... -
Next Generation Sequencing for Measurable Residual Disease Detection in Acute Myeloid Leukemia
(2019-10-30)Acute myeloid leukemia (AML) is the most common form of acute leukemia and generally associated with a poor prognosis. For both children and adults, the treatment is based on chemotherapy. Allogeneic hematopoietic stem ... -
NK cell recognition of malignant cells - a CRISPR approach to define novel mediators
(2024-03-14)Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system, capable of eliminating malignant cells. Their activity is intricately regulated through a balanced interplay between activating and inhibitory ... -
Norovirus Tracing in Environmental and Outbreak Settings - Experiences of waterborne, foodborne and nosocomial transmission
(2015-05-04)Noroviruses (NoV), a major cause of acute gastroenteritis in hospital settings, also occur as sporadic infections or periodic non-seasonal community outbreaks. Human NoV replicates to high concentration in the intestinal ... -
Norovirus, causative agent of winter vomiting disease, exploits several histo-blood group glycans for adhesion
(2009-05-20)Norovirus is recognized as the major cause of outbreaks of gastroenteritis world-wide, yet no vaccines or drugs are available for prevention or treatment of the virus infection. Challenge studies and binding studies using ... -
Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
(2019-11-13)Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis ... -
On cerebrospinal fluid biomarkers of HIV-1 infection
(2015-11-26)HIV invades the central nervous system (CNS) shortly after transmission and is present throughout the course of infection, causing immune activation and neuroinflammation. If left untreated, more than 20% of patients with ... -
On chaperone co-operation in temporal and spatial protein quality control
(2021-03-29)In order for a protein to be able to function correctly it needs to adopt its proper fold. Because of this, protein quality control (PQC) is vital at every level of cellular function. The central protein in PQC networks ... -
On community acquired infections requiring intensive care
(2015-01-07)Acute bacterial meningitis (ABM), influenza, and necrotizing soft-tissue infections (NSTIs) are diseases that in a short period of time can progress to become life threatening. Individuals with severe forms of these ... -
On gastrointestinal viral infections
(2022-11-10)Gastrointestinal viral infections cause considerable morbidity and mortality worldwide. Many factors influencing clinical presentation, disease severity, epidemiology, and transmission are not fully understood. The aims ... -
On HIV in the elderly and vitamin B metabolism in HIV infection
(2022-01-17)The evolution of the human deficiency virus (HIV) field is unparalleled in the history of infectious diseases. From the first cases in the beginning of the 1980s, when an HIV diagnosis was a death sentence, through the ... -
On HIV-1 latency and viral reservoirs
(2015-05-11)HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor ... -
On morbidity and mortality in novovirus infection
(2014-12-02)Norovirus causes epidemic gastroenteritis. The extent of excess mortality related to norovirus infections is not established and factors that influence the duration of viral shedding have not been determined. The aims of ...